Transcriptional regulation of the IL-2 gene

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

MAPKs: new JNK expands the group

1994 • 949 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA

1995 • 718 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

1994 • 313 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

1995 • 300 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

1993 • 264 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

The ups and downs of T cell costimulation

1994 • 240 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.

1993 • 214 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

Identification of a Zinc Finger Protein that Inhibits IL-2 Gene Expression

1991 • 195 citations

Difference in transcriptional regulatory function between c-Fos and Fra-2

1991 • 194 citations

Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.

1994 • 191 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

1993 • 181 citations

Analysis of the AP-1 sites in the IL-2 promoter.

1992 • 179 citations

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.

1993 • 177 citations

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

1986 • 171 citations

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.

1994 • 166 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region

1995 • 146 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Interleukin-2 Transcription Is Regulated In Vivo at the Level of Coordinated Binding of Both Constitutive and Regulated Factors

1994 • 138 citations

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.

1994 • 134 citations

Transcription factor interactions: basics on zippers

1991 • 124 citations

NF-AT-AP-1 and Rel-bZIP: Hybrid vigor and binding under the influence

1994 • 118 citations

lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

1994 • 115 citations

Mechanisms regulating the level of IL-2 mRNA in T lymphocytes.

1988 • 115 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA

1994 • 110 citations

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

1991 • 108 citations

Regulatory anatomy of the murine interleukin-2 gene

1990 • 106 citations

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1994 • 105 citations

Regulation of cytokine gene expression in T helper cell subsets.

1994 • 102 citations

Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

1994 • 101 citations

Physiologic activation of T cells via the T cell receptor induces NF-kappa B.

1991 • 95 citations

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

1995 • 93 citations

cAMP up-regulates IL-4 and IL-5 production from activated CD4⁺ T cells while decreasing IL-2 release and NF-AT induction

1994 • 93 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1990 • 91 citations

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

1994 • 91 citations

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

1994 • 90 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

Transformation by Fos proteins requires a C-terminal transactivation domain.

1993 • 82 citations

Induction, suppression and superinduction of lymphokine mRNA in T lymphocytes

1987 • 82 citations

Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.

1994 • 81 citations

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.

1992 • 69 citations

Normal Peripheral T-Cell Function in c-Fos-Deficient Mice

1994 • 68 citations

Phosphorylation of NF-KB1-p50 is involved in NF-kappa B activation and stable DNA binding.

1994 • 66 citations

Molecular Regulation of the IL‐2 Gene: Rheostatic Control of the Immune System

1993 • 64 citations

The weak, fine-tuned binding of ubiquitous transcription factors to the II-2 enhancer contributes to its T cell-restricted activity

1992 • 62 citations

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.

1994 • 58 citations

Induction of the POU Domain Transcription Factor Oct-2 during T-Cell Activation by Cognate Antigen

1992 • 57 citations

Transcriptional regulation of cytokine genes in nontransformed T cells. Apparent constitutive signals in run-on assays can be caused by repeat sequences.

1991 • 56 citations

The Cyclosporin‐sensitive Transcription Factor NFATp Is Expressed in Several Classes of Cells in the Immune System^a

1995 • 54 citations

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells

1994 • 49 citations

Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.

1995 • 48 citations

Cyclosporin A sensitivity of the NF-χB site of the IL2Rα promoter in untransformed murine T cells

1994 • 44 citations

Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.

1994 • 42 citations

Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.

1993 • 41 citations

Role of ETS1 in IL-2 gene expression.

1995 • 40 citations

Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals

1992 • 38 citations

A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly.

1994 • 37 citations

IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice

1994 • 35 citations

In vivofootprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells

1993 • 31 citations

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.

1993 • 30 citations

Analysis of IL-2 gene regulation in c-fos transgenic mice. Evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex.

1994 • 27 citations

Positive and negative regulation of IL-2 gene expression: Role of multiple regulatory sites

1994 • 22 citations

Activation of a novel serine/threonine kinase that phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors.

1994 • 18 citations