Knock-down of the Type 3 Ryanodine Receptor Impairs Sustained Ca2+ Signaling via the T Cell Receptor/CD3 Complex

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Ca ²⁺ -Induced Ca ²⁺ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose

1991 • 628 citations

Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers

2001 • 426 citations

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose

1999 • 308 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp+) Is an Essential Regulator of T-Lymphocyte Ca2+-Signaling

2000 • 177 citations

What makes an mRNA anti-sensi-itive?

1993 • 150 citations

The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

1995 • 143 citations

Ryanodine Receptor-Ankyrin Interaction Regulates Internal Ca2+ Release in Mouse T-lymphoma Cells

1995 • 137 citations

Requirement of Ryanodine Receptor Subtypes 1 and 2 for Ca2+-induced Ca2+ Release in Vascular Myocytes

2000 • 118 citations

Intracellular Ca2+ pools in Jurkat T-lymphocytes

1993 • 104 citations

Ca2+ Entry Induced by Cyclic ADP-ribose in Intact T-Lymphocytes

1997 • 94 citations

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.

1995 • 85 citations

7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist

1997 • 85 citations

Cyclic ADP-Ribose and NAADP: Structures, Metabolism and Functions

2002 • 84 citations

Involvement of the brain type of ryanodine receptor in T‐cell proliferation

1994 • 79 citations

Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells

2001 • 62 citations

Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and Cell Function

2002 • 55 citations

Contribution of Ryanodine Receptor Subtype 3 to Ca2+Responses in Ca2+-overloaded Cultured Rat Portal Vein Myocytes

2001 • 49 citations

T-cell receptor-mediated metabolism of inositol polyphosphates in Jurkat T-lymphocytes. Identification of a D-myo-inositol 1,2,3,4,6-pentakisphosphate-2-phosphomonoesterase activity, a D-myo-inositol 1,3,4,5,6-pentakisphosphate-1/3-phosphatase activity and a D/L-myo-inositol 1,2,4,5,6-pentakisphosphate-1/3-kinase activity.

1991 • 41 citations

Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells

2001 • 38 citations

Novel Hydrolysis-Resistant Analogues of Cyclic ADP-ribose: Modification of the “Northern” Ribose and Calcium Release Activity

2002 • 37 citations

Intracellular Ca2+ release mechanisms: multiple pathways having multiple functions within the same cell type?

2000 • 36 citations

Transient Tyrosine Phosphorylation of Human Ryanodine Receptor upon T Cell Stimulation

2001 • 32 citations

Mechanisms involved in α6β1-integrin-mediated Ca2+ signalling

2001 • 27 citations

Regulation of cADP-ribose-induced Ca2+ Release by Mg2+ and Inorganic Phosphate

1996 • 21 citations

Pharmacological activation of the ryanodine receptor in Jurkat T‐lymphocytes

1999 • 19 citations

Assay for ADP-Ribosyl Cyclase by Reverse-Phase High-Performance Liquid Chromatography

2001 • 17 citations

A Caffeine/Ryanodine-sensitive Ca2+ Pool Is Involved in Triggering Spontaneous Variations of Ca2+ in Jurkat T Lymphocytes by a Ca2+-induced Ca2+ Release (CICR) Mechanism

1997 • 15 citations

Dictyostetium Double-Stranded Ribonuclease

2001 • 10 citations

Ca2+ Release Induced by Cyclic ADP Ribose in Mice Lacking Type 3 Ryanodine Receptor

2001 • 8 citations