The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Structure and Regulation of Voltage-Gated Ca²⁺ Channels

2000 • 2,264 citations

Homeostasis of Naive and Memory T Cells

2008 • 1,123 citations

Calcium signalling in lymphocyte activation and disease

2007 • 990 citations

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness

1998 • 493 citations

Calcium signaling in immune cells

2008 • 460 citations

L-Type Calcium Channels: The Low Down

2004 • 417 citations

Mutation of the Ca2+ Channel β Subunit Gene Cchb4 Is Associated with Ataxia and Seizures in the Lethargic (lh) Mouse

1997 • 399 citations

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels

2007 • 388 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and Ca _V 1.2 Channels

2010 • 329 citations

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

2010 • 317 citations

Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane

1994 • 305 citations

The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis

2000 • 301 citations

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

2008 • 288 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina

2005 • 259 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

Regulation of mature T cell homeostasis

2005 • 191 citations

TheCACNA1FGene Encodes an L-Type Calcium Channel with Unique Biophysical Properties and Tissue Distribution

2004 • 186 citations

RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

2002 • 153 citations

The Ras/MAPK cascade and the control of positive selection

2003 • 142 citations

Calcium signaling in the development and function of T‐lineage cells

2009 • 142 citations

Functional Characterization of the L-type Ca²⁺Channel Ca_v1.4α1 from Mouse Retina

2004 • 113 citations

Identification and Functional Characterization of Voltage-dependent Calcium Channels in T Lymphocytes

2003 • 107 citations

Critical role for the β regulatory subunits of Cav channels in T lymphocyte function

2006 • 99 citations

Molecular characterization of L-type calcium channel splice variants expressed in human T lymphocytes

2005 • 73 citations

Non-voltage-gated L-type Ca2+ Channels in Human T Cells

2004 • 73 citations

Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

2009 • 61 citations

Roles of CRAC and CaV-like channels in T cells: more than one gatekeeper?

2006 • 49 citations

ERK and cell death: ERK location and T cell selection

2009 • 40 citations

Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca²⁺ store depletion

2008 • 37 citations

A non-voltage-gated calcium channel with L-type characteristics activated by B cell receptor ligation

2003 • 36 citations

Chronic Immunodeficiency in Mice Lacking RasGRP1 Results in CD4 T Cell Immune Activation and Exhaustion

2007 • 35 citations

Pure Lipopolysaccharide or Synthetic Lipid A Induces Activation of p21Ras in Primary Macrophages through a Pathway Dependent on Src Family Kinases and PI3K

2005 • 32 citations

The high-affinity immunoglobulin E receptor (FcɛRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcɛRIβ chain immunoreceptor tyrosine-based activation motif

2007 • 22 citations

RasGRP1 Transmits Prodifferentiation TCR Signaling That Is Crucial for CD4 T Cell Development

2006 • 22 citations