Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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Regulatory T Cells and Immune Tolerance

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

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CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

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Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

CD45: A Critical Regulator of Signaling Thresholds in Immune Cells

2003 • 849 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Foxp3⁺natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation

2008 • 663 citations

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3⁺ conventional T cells

2007 • 658 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

2006 • 474 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus

2005 • 457 citations

Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood

2002 • 442 citations

The immune paradox of sarcoidosis and regulatory T cells

2006 • 433 citations

MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells

2006 • 416 citations

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

2006 • 407 citations

Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

2006 • 394 citations

Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 • 359 citations

A peripheral circulating compartment of natural naive CD4+ Tregs

2005 • 299 citations

Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model

2003 • 252 citations

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans

2008 • 227 citations

Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool

2008 • 213 citations

Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death

2006 • 170 citations

FoxP3+ Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions

2009 • 125 citations

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