Protein Kinase Cθ in T Cell Activation

Functional rafts in cell membranes

1997 • 9,471 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

AP-1 function and regulation

1997 • 2,833 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

14-3-3 Proteins: Structure, Function, and Regulation

2000 • 1,552 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Signal transduction through NF-κB

1998 • 1,103 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Fas Ligand-Induced Apoptosis

1999 • 778 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Nef Harbors a Major Determinant of Pathogenicity for an AIDS-like Disease Induced by HIV-1 in Transgenic Mice

1998 • 448 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Costimulatory regulation of T cell function

1999 • 391 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

2000 • 381 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function

1996 • 371 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

GPI-microdomains: a role in signalling via immunoreceptors

1999 • 270 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

Protein kinase C binding partners

2000 • 264 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

Activation-induced death of mature T cells in the regulation of immune responses

1995 • 248 citations

Mechanism of Interaction of Protein Kinase C with Phorbol Esters

1995 • 243 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway

1999 • 234 citations

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

1995 • 233 citations

Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

1994 • 227 citations

A Novel Functional Interaction between Vav and PKCθ Is Required for TCR-Induced T Cell Activation

2000 • 226 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

2001 • 222 citations

Two NFAT Transcription Factor Binding Sites Participate in the Regulation of CD95 (Fas) Ligand Expression in Activated Human T Cells

1997 • 222 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

The Actin Cytoskeleton and Lymphocyte Activation

1999 • 218 citations

Protein Kinase C-θ Phosphorylation of Moesin in the Actin-binding Sequence

1998 • 213 citations

The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases

1999 • 208 citations

Regulation of Lymphocyte Function by Protein Phosphorylation

1993 • 203 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1991 • 192 citations

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.

1992 • 191 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.

1977 • 188 citations

Inhibition of the c-Jun N-terminal Kinase/AP-1 and NF-κB Pathways by PICOT, a Novel Protein Kinase C-interacting Protein with a Thioredoxin Homology Domain

2000 • 186 citations

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1999 • 180 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

Direct Interaction between Protein Kinase Cθ (PKCθ) and 14-3-3τ in T Cells: 14-3-3 Overexpression Results in Inhibition of PKCθ Translocation and Function†

1996 • 158 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

1998 • 156 citations

Involvement of p21^ras activation in T cell CD69 expression

1994 • 154 citations

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.

1987 • 153 citations

Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization

2000 • 149 citations

CD28 and apoptosis

1995 • 147 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Lymphocyte Activation by the Tumor-Promoting Agent 12-O-Tetradecanoylphorbol-13-Acetate (TPA)

1979 • 145 citations

Protein kinase Cθ: a new essential superstar on the T-cell stage

2000 • 144 citations

Fas-ligand: Privilege and peril

1997 • 142 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

1999 • 137 citations

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1

1996 • 137 citations

Protein Kinase C θ and ε Promote T-cell Survival by a Rsk-dependent Phosphorylation and Inactivation of BAD

2000 • 136 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif

1997 • 135 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

1999 • 127 citations

Protein Kinase C (PKC) Inhibits Fas Receptor-induced Apoptosis through Modulation of the Loss of K+ and Cell Shrinkage

2000 • 127 citations

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

1992 • 123 citations

Membrane compartmentation and the response to antigen

1999 • 118 citations

Regulation of Protein Kinase Cθ Function during T Cell Activation by Lck-mediated Tyrosine Phosphorylation

2000 • 118 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

1996 • 113 citations

Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1999 • 113 citations

Activation-modulated Association of 14–3–3 Proteins with Cbl in T Cells

1996 • 109 citations

Human T lymphocyte activation by tumor promoters: role of protein kinase C.

1987 • 106 citations

Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death

1999 • 105 citations

Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.

1997 • 104 citations

The HIV Nef Protein Associates with Protein Kinase C Theta

1996 • 100 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

Phorbol esters inhibit apoptosis in IL-2-dependent T lymphocytes

1989 • 95 citations

Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation

2000 • 93 citations

Regulation of the Interleukin-2 CD28-Responsive Element by NF-ATp and Various NF-κB/Rel Transcription Factors

1997 • 90 citations

Cbl

1998 • 89 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules

2000 • 88 citations

Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.

1996 • 85 citations

Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

1985 • 83 citations

Expression and Biochemical Characterization of Human Protein Kinase C‐θ

1994 • 83 citations

A new possible regulatory system for protein phosphorylation in human peripheral lymphocytes. I. Characterization of a calcium-activated, phospholipid-dependent protein kinase.

1981 • 82 citations

Protein Kinase C-θ Mediates a Selective T Cell Survival Signal Via Phosphorylation of BAD

2001 • 81 citations

DiGeorge anomaly associated with 10p deletion

1991 • 81 citations

Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance.

1994 • 80 citations

Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB

1997 • 78 citations

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

1998 • 77 citations

Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells

2001 • 77 citations

Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation

1994 • 76 citations

T lymphocyte activation: a biological model of signal transduction.

1990 • 76 citations

Protein kinase C isoenzymes in rat and human cardiovascular tissues

1997 • 75 citations

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

2001 • 74 citations

Impaired Plasma Membrane Targeting of Grb2–Murine Son of Sevenless (mSOS) Complex and Differential Activation of the Fyn–T Cell Receptor (TCR)-ζ–Cbl Pathway Mediate T Cell Hyporesponsiveness in Autoimmune Nonobese Diabetic Mice

1997 • 70 citations

IκB Kinases Serve as a Target of CD28 Signaling

1998 • 69 citations

Different Protein Kinase C Isoenzymes Regulate IL-2 Receptor Expression or IL-2 Synthesis in Human Lymphocytes Stimulated via the TCR

1998 • 68 citations

The Cbl Family of Signal Transduction Molecules

1997 • 67 citations

T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase

2000 • 66 citations

Membrane lipid microdomains and the role of PKCθ in T cell activation

2001 • 65 citations

Protein Kinase C-θ (PKCθ) Distribution Analysis in Hematopoietic Cells: Proliferating T Cells Exhibit High Proportions of PKCθ in the Particulate Fraction

1999 • 63 citations

c‐Cbl: A regulator of T cell receptor‐mediated signalling

1998 • 63 citations

Nef 27, but Not the Nef 25 Isoform of Human Immunodeficiency Virus-Type 1 pNL4.3 Down-Regulates Surface CD4 and IL-2R Expression in Peripheral Blood Mononuclear Cells and Transformed T Cells

1994 • 62 citations

14-3-3 proteins and growth control

2000 • 60 citations

New Perspectives on PKCθ, a Member of the Novel Subfamily of Protein Kinase C

1998 • 59 citations

T cell expressed PKCθ demonstrates cell‐type selective function

2000 • 59 citations

HIV-1 Nef Protein Inhibits the Recruitment of AP-1 DNA-Binding Activity in Human T-Cells

1993 • 58 citations

Developmental regulation of a protein kinase C isoform localized in the neuromuscular junction

1995 • 58 citations

Protein Kinase C-θ Participates in the Activation of Cyclic AMP-Responsive Element-Binding Protein and Its Subsequent Binding to the −180 Site of the IL-2 Promoter in Normal Human T Lymphocytes

2001 • 58 citations

Vav Synergizes with Protein Kinase CΘ to Mediate IL-4 Gene Expression in Response to CD28 Costimulation in T Cells

2000 • 58 citations

Calcium ionophore plus phorbol ester can substitute for antigen in the induction of cytolytic T lymphocytes from specifically primed precursors.

1985 • 57 citations

The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent

1996 • 56 citations

Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ

2001 • 54 citations

The p38 Mitogen-Activated Protein Kinase Pathway in Activated and Anergic Th1 Cells

1997 • 53 citations

Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A

1995 • 52 citations

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

1999 • 52 citations

T cell expressed PKCθ demonstrates cell-type selective function

2000 • 50 citations

T cell antigen receptor signal transduction pathways.

1996 • 49 citations

Membrane Raft Association of CD47 Is Necessary for Actin Polymerization and Protein Kinase C θ Translocation in Its Synergistic Activation of T Cells

2001 • 49 citations

In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase

1995 • 48 citations

Reaction of T lymphocytes with anti-T3 induces translocation of C-kinase activity to the membrane and specific substrate phosphorylation.

1987 • 47 citations

Unique expression pattern of protein kinase C‐θ: high mRNA levels in normal mouse testes and in T‐lymphocytic cells and neoplasms

1993 • 46 citations

The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the I kappa B kinase cascade.

1999 • 46 citations

Apoptosis but Not Other Activation Events Is Inhibited by a Mutation in the Transmembrane Domain of T Cell Receptor β That Impairs CD3ζ Association

1996 • 46 citations

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.

1987 • 46 citations

Protein Kinase C Activation Inhibits Tyrosine Phosphorylation of Cbl and Its Recruitment of Src Homology 2 Domain-Containing Proteins

1999 • 41 citations

The Role of p56^ICk and p59^fyn Tyrosine Kinases and CD45 Protein Tyrosine Phosphatase in T‐cell Development and Clonal Selection

1993 • 40 citations

The Jun Kinase Cascade Is Responsible for Activating the CD28 Response Element of the IL-2 Promoter: Proof of Cross-Talk with the IκB Kinase Cascade

1999 • 38 citations

Direct Interaction in T-cells between θPKC and the Tyrosine Kinase p59fyn

1999 • 37 citations

A critical role for p59fyn in CD2-based signal transduction

2000 • 37 citations

A newly identified response element in the CD95 ligand promoter contributes to optimal inducibility in activated T lymphocytes.

1998 • 34 citations

Inhibition of the protein kinase C pathway promotes anti-CD95-induced apoptosis in Jurkat T cells

1998 • 31 citations

Cutting Edge: A Newly Identified Response Element in the CD95 Ligand Promoter Contributes to Optimal Inducibility in Activated T Lymphocytes

1998 • 26 citations

Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter

1998 • 23 citations

Mapping of the human protein kinase C-θ (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH

1995 • 17 citations

Untitled

1999 • 17 citations

Perspective: Research Highlights at the Gladstone Institute of Virology and Immunology: Unraveling the Function of HIV Type 1 Nef

1996 • 16 citations

Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C

1999 • 15 citations

Chromosomal abnormalities in adult T-cell leukemia/lymphoma (ATL)

1987 • 14 citations

Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell

1999 • 6 citations