Genetic Predictors of the Clinical Response to Opioid Analgesics

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Allelic Variation of Human Serotonin Transporter Gene Expression

1996 • 2,225 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

Gender variations in clinical pain experience

1996 • 1,525 citations

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

1995 • 1,424 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

1992 • 1,138 citations

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

1998 • 1,055 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

1991 • 928 citations

Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism

2002 • 919 citations

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

1993 • 883 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

The Control of Pain in Peripheral Tissue by Opioids

1995 • 733 citations

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

1982 • 672 citations

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

2002 • 670 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

1999 • 648 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

Polymorphisms in OATP-C

2001 • 605 citations

Molecular Basis of Ethnic Differences in Drug Disposition and Response

2001 • 595 citations

An inventory of the human ABC proteins

1999 • 587 citations

Interindividual Variability of the Clinical Pharmacokinetics of Methadone

2002 • 571 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

2002 • 551 citations

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

2001 • 538 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

Kappa–opioids produce significantly greater analgesia in women than in men

1996 • 461 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

CHRONIC IDIOPATHIC JAUNDICE WITH UNIDENTIFIED PIGMENT IN LIVER CELLS

1954 • 442 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

The genetic mediation of individual differences in sensitivity to pain and its inhibition

1999 • 435 citations

The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat

1967 • 431 citations

Geographical/Interracial Differences in Polymorphic Drug Oxidation

1995 • 431 citations

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

1993 • 429 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Increased drug delivery to the brain by P-glycoprotein inhibition

2000 • 422 citations

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1995 • 419 citations

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

2001 • 418 citations

Systematic review of outpatient services for chronic pain control.

1997 • 416 citations

Human UGT2B7 catalyzes morphine glucuronidation.

1997 • 416 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

Association of antipsychotic druginduced weight gain with a 5-HT2C receptor gene polymorphism

2002 • 405 citations

Identification and Characterization of a Prostaglandin Transporter

1995 • 400 citations

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.

2000 • 399 citations

The hypoalgesic effect of tramadol in relation to CYP2D6*

1996 • 398 citations

Glucuronidation in Humans

1999 • 390 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

2001 • 377 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord

1997 • 372 citations

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.

1995 • 362 citations

Sex Differences in Morphine Analgesia

2000 • 356 citations

Isolation and structural organization of the human preproenkephalin B gene

1983 • 351 citations

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity

2000 • 346 citations

μ-Opioid Receptor-Mediated Antinociceptive Responses Differ in Men and Women

2002 • 345 citations

Gender and Age Influences on Human Brain Mu-Opioid Receptor Binding Measured by PET

1999 • 332 citations

Association between clozapine response and allelic variation in 5-HT2A receptor gene

1995 • 330 citations

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

1998 • 320 citations

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.

2001 • 319 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Genetic Polymorphisms of the HumanMDR1Drug Transporter

2003 • 308 citations

Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene

2002 • 307 citations

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1968 • 301 citations

Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region

1999 • 299 citations

Sequence variability and candidate gene analysis in complex disease: association of micro opioid receptor gene variation with substance dependence

2000 • 291 citations

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human µ-opioid receptor

2000 • 287 citations

Human μ opiate receptor

1994 • 286 citations

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

2002 • 281 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

μ opioid receptor gene variants: lack of association with alcohol dependence

1997 • 278 citations

The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain

1999 • 270 citations

Opiate-induced Analgesia Is Increased and Prolonged in Mice Lacking P-glycoprotein

2000 • 270 citations

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

2002 • 268 citations

Genetic variation in cyclooxygenase 1: Effects on response to aspirin

2003 • 265 citations

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1998 • 260 citations

Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2.

1997 • 260 citations

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1998 • 259 citations

Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord

1995 • 258 citations

Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)

2001 • 255 citations

The intrinsic antinociceptive effects of oxycodone appear to be κ -opioid receptor mediated

1997 • 252 citations

Mu receptor binding of some commonly used opioids and their metabolites

1991 • 252 citations

MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

2002 • 250 citations

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3.

1998 • 250 citations

The Mu-Opioid Receptor Gene Polymorphism (A118G) Alters HPA Axis Activation Induced by Opioid Receptor Blockade

2002 • 246 citations

Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

1999 • 245 citations

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

2000 • 244 citations

Contribution of monoaminergic modulation to the analgesic effect of tramadol

1996 • 244 citations

Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics

1996 • 243 citations

A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling

2001 • 243 citations

Interaction of the central analgesic, tramadol, with the uptake and release of 5‐hydroxytryptamine in the rat brain in vitro

1992 • 241 citations

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1996 • 238 citations

d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia.

1999 • 237 citations

Heritability of nociception II. ‘Types’ of nociception revealed by genetic correlation analysis

1999 • 236 citations

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

2001 • 235 citations

Impact of environmental and genetic factors on codeine analgesia

1991 • 235 citations

Gender Differences in Opioid-mediated Analgesia

2000 • 233 citations

Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets

2002 • 232 citations

Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone*

1998 • 230 citations

Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein

2001 • 229 citations

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.

1995 • 228 citations

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

2001 • 227 citations

Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver Microsomes

1996 • 225 citations

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

2003 • 222 citations

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

1993 • 222 citations

Isolation and structural organization of the human preproenkephalin gene

1982 • 217 citations

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine

1998 • 214 citations

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

2001 • 212 citations

Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein

2002 • 209 citations

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

2001 • 208 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

The pharmacogenetics of codeine hypoalgesia

1995 • 205 citations

The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

1999 • 204 citations

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

2002 • 204 citations

The effects of the human MDR1 genotype on the expression of duodenal P‐glycoprotein and disposition of the probe drug talinolol

2002 • 201 citations

Ethnicity and the pain experience

1984 • 201 citations

The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia

1999 • 200 citations

Ultrarapid metabolizers of debrisoquine: Characterization and PCR‐based detection of alleles with duplication of the CYP2D6 gene

1996 • 198 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

2002 • 194 citations

Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro

1993 • 193 citations

MDR1 Genotype-Related Pharmacokinetics and Pharmacodynamics.

2002 • 192 citations

Unique CYP2D6 activity distribution and genotype‐phenotype discordance in black Americans

2002 • 189 citations

Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide.

1980 • 181 citations

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone

1993 • 179 citations

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

2001 • 178 citations

Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

2003 • 177 citations

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

2002 • 176 citations

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.

1996 • 175 citations

Sex-related Differences in the Influence of Morphine on Ventilatory Control in Humans

1998 • 173 citations

Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.

1996 • 171 citations

Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

1995 • 171 citations

Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus

1997 • 168 citations

Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)

1999 • 167 citations

Molecular genetic basis of Gilbert's syndrome

1999 • 167 citations

Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4.

1998 • 162 citations

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

2003 • 160 citations

Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)

2001 • 160 citations

Opioid analgesics as noncompetitive N-methyl-d-aspartate (NMDA) antagonists

1998 • 159 citations

Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man

1985 • 156 citations

Differences in postoperative pain severity among four ethnic groups

1994 • 155 citations

Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception.

1997 • 154 citations

Interethnic differences in pain perception

1991 • 154 citations

Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver

1995 • 154 citations

The organic anion transporter family: from physiology to ontogeny and the clinic

2001 • 153 citations

Opioid receptor and peptide gene polymorphisms: potential implications for addictions

2000 • 153 citations

Functional Characterization of Coding Polymorphisms in the HumanMDR1 Gene Using a Vaccinia Virus Expression System

2002 • 152 citations

Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.

1990 • 151 citations

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

2003 • 150 citations

Polymorphic CYP2D6 mediates O -demethylation of the opioid analgesic tramadol

1997 • 150 citations

Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts

2001 • 149 citations

�-Adrenoceptor polymorphisms

2004 • 144 citations

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

2002 • 143 citations

Ondansetron Inhibits the Analgesic Effects of Tramadol: A Possible 5-HT3 Spinal Receptor Involvement in Acute Pain in Humans

2002 • 140 citations

Codeine O‐demethylation co‐segregates with polymorphic debrisoquine hydroxylation.

1989 • 139 citations

Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR)

2002 • 134 citations

Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.

2001 • 133 citations

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine

1996 • 132 citations

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

2002 • 132 citations

Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects.

2002 • 131 citations

The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain.

1994 • 131 citations

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.

1991 • 129 citations

The Analgesic Efficacy of Tramadol is Impaired by Concurrent Administration of Ondansetron

2001 • 127 citations

Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

1996 • 125 citations

Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

1997 • 124 citations

Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.

2001 • 122 citations

Systematic review of outpatient services for chronic pain control.

1997 • 120 citations

Insidious Intoxication After Morphine Treatment in Renal Failure: Delayed Onset of Morphine-6-glucuronide Action

2000 • 118 citations

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

2001 • 114 citations

Ritonavir's Role in Reducing Fentanyl Clearance and Prolonging Its Half-life

1999 • 114 citations

Ondansetron Inhibits the Analgesic Effects of Tramadol: A Possible 5-HT3 Spinal Receptor Involvement in Acute Pain in Humans

2002 • 113 citations

Identification and Functional Analysis of Two Novel Mutations in the Multidrug Resistance Protein 2 Gene in Israeli Patients with Dubin-Johnson Syndrome

2001 • 112 citations

Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.

1988 • 107 citations

Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency.

1999 • 107 citations

Personality and polymorphisms of genes involved in aminergic neurotransmission

2000 • 104 citations

Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans

1992 • 104 citations

Association between a delta opioid receptor gene polymorphism and heroin dependence in man

1997 • 104 citations

Mrp2 is essential for estradiol-17β(β-D -glucuronide)–induced cholestasis in rats

2000 • 103 citations

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.

1993 • 102 citations

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?

2001 • 100 citations

Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia

2001 • 99 citations

Single-Step Assays to Analyze CYP2D6 Gene Polymorphisms in Asians: Allele Frequencies and a Novel *14B Allele in Mainland Chinese

2002 • 98 citations

A functional polymorphism within the μ-opioid receptor gene and risk for abuse of alcohol and other substances

2002 • 98 citations

Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy

2001 • 98 citations

The antinociceptive effect of tramadol in the formalin test is mediated by the serotonergic component

2002 • 96 citations

Effect of preoperative oral dextromethorphan on immediate and late postoperative pain and hyperalgesia after total abdominal hysterectomy

2000 • 96 citations

The effect of quinidine on the analgesic effect of codeine

1992 • 95 citations

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4

1997 • 94 citations

Nonreplication of association between ?-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence

2001 • 93 citations

Predictive factors of early morphine requirements in the post-anaesthesia care unit (PACU)

2001 • 92 citations

Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects.

1999 • 92 citations

Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins

2001 • 91 citations

Paroxetine Increases Steady-State Concentrations of (R)-Methadone in CYP2D6 Extensive but Not Poor Metabolizers

2002 • 91 citations

Ethnicity influences morphine pharmacokinetics and pharmacodynamics

2001 • 90 citations

CODEINE ANALGESIA IS DUE TO CODEINE‐6‐GLUCURONIDE, NOT MORPHINE

2000 • 90 citations

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

2003 • 89 citations

Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualization

2001 • 89 citations

Codeine analgesia is due to codeine-6-glucuronide, not morphine.

2000 • 87 citations

Polymorphisms in genes involved in neurotransmission in relation to smoking

2000 • 86 citations

Does opioid analgesia show a gender preference for females?

1999 • 85 citations

Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14–q21 and mouse chromosome 14

1991 • 85 citations

The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone

1976 • 84 citations

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood–brain and blood–cerebrospinal fluid barriers: importance in the drug delivery to the brain

1999 • 82 citations

Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype

1996 • 82 citations

Effect of P‐glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

2000 • 80 citations

Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability.

1997 • 80 citations

C3435T Mutation in Exon 26 of the Human MDR1 Gene and Cyclosporine Pharmacokinetics in Healthy Subjects

2002 • 79 citations

Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

1996 • 79 citations

Morphine-6-Glucuronide might Mediate the Prolonged Opioid Effect of Morphine in Acute Renal Failure

1990 • 78 citations

Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse

1997 • 77 citations

Association of a functional ?-opioid receptor allele (+118A) with alcohol dependency

1999 • 76 citations

Cyclooxygenase 1(COX1) polymorphisms in African-American and caucasian populations

2002 • 75 citations

Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling

2000 • 73 citations

Patient‐controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan.

1995 • 72 citations

Single Nucleotide Polymorphisms in the Human μ Opioid Receptor Gene Alter Basal G Protein Coupling and Calmodulin Binding

2001 • 71 citations

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

1997 • 71 citations

Human Alfentanil Metabolism by Cytochrome P450 3A3/4. An Explanation for the Interindividual Variability in Alfentanil Clearance?

1993 • 70 citations

Serotonergic Genes and Suicidality

2001 • 70 citations

Physiological Genomics of Antidepressant Targets: Keeping the Periphery in Mind

2001 • 69 citations

Methadone Withdrawal when Starting an Antiretroviral Regimen Including Nevirapine

1999 • 68 citations

Modelling of the blood‐brain barrier transport of morphine‐3‐glucuronide studied using microdialysis in the rat: involvement of probenecid‐sensitive transport

2000 • 67 citations

Cultural and educational influences on pain of childbirth

1989 • 67 citations

Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene

2001 • 67 citations

Dihydrocodeine: A new opioid substrate for the polymorphic CYP2D6 in humans*

1995 • 66 citations

Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test

1988 • 65 citations

Decreased Methadone Effect after Ritonavir Initiation

2000 • 65 citations

Increased CNS uptake and enhanced antinociception of morphine‐6‐glucuronide in rats after inhibition of P‐glycoprotein

2002 • 64 citations

Polymorphic drug oxidation in humans.

1984 • 62 citations

Morphine formation from codeine in rat brain: A possible mechanism of codeine analgesia

1990 • 62 citations

Ultrarapid metabolism of sparteine

1998 • 62 citations

Tryptophan loading may reverse tolerance to opiate analgesics in humans: A preliminary report

1980 • 61 citations

Localization of the CYP2D Gene Locus to Human Chromosome 22q13.1 by Polymerase Chain Reaction, in Situ Hybridization, and Linkage Analysis

1993 • 61 citations

Human ?-opioid receptor gene and susceptibility to heroin and alcohol dependence

1999 • 61 citations

Long lasting respiratory depression induced by morphine‐6‐glucuronide?

1989 • 60 citations

Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons

1988 • 60 citations

DUPLICATION, MULTIDUPLICATION, AND AMPLIFICATION OF GENES ENCODING DRUG-METABOLIZING ENZYMES: EVOLUTIONARY, TOXICOLOGICAL, AND CLINICAL PHARMACOLOGICAL ASPECTS

1999 • 58 citations

Effects of tramadol stereoisomers on norepinephrine efflux and uptake in the rat locus coeruleus measured by real time voltammetry

1999 • 57 citations

[Duality of the analgesic effect of tramadol in humans].

1993 • 57 citations

Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy.

1999 • 57 citations

Codeine disposition in smokers and nonsmokers

1982 • 56 citations

Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans

1999 • 56 citations

Sex differences in opioid analgesia

1999 • 56 citations

Evidence for polymorphic oxidation of sparteine in Japanese subjects.

1987 • 55 citations

Concordance between Tramadol and Dextromethorphan Parent/Metabolite Ratios: The Influence of CYP2D6 and Non‐CYP2D6 Pathways on Biotransformation

2002 • 55 citations

Inhibition of Cytochrome P450 2D6 Modifies Codeine Abuse Liability

2000 • 55 citations

Regional expression and chromosomal localization of the delta opiate receptor gene.

1993 • 55 citations

A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

1991 • 54 citations

The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl

1998 • 54 citations

The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross‐over study with extensive and quinidine‐induced poor metabolizers

1998 • 53 citations

Involvement of the Multidrug Resistance Protein 3 in Drug Sensitivity and Its Expression in Human Glioma

2001 • 52 citations

Identification and functional characterization of α2-adrenoceptor polymorphisms

2001 • 52 citations

Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients

2001 • 51 citations

Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats.

2000 • 50 citations

Interethnic differences of drug-metabolizing enzymes

2000 • 49 citations

Impaired Receptor Binding and Activation Associated with a Human Prostacyclin Receptor Polymorphism

2002 • 47 citations

Codeine in post-operative pain

1998 • 46 citations

Perioperative Dextromethorphan Reduces Postoperative Pain After Hysterectomy

1999 • 44 citations

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor

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Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

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Ethnic Differences in Drug Disposition and Response

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Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence

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Splice variants but not mutations of DNA polymerase beta are common in bladder cancer.

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Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine1A/1B antagonist, enhances the analgesic effect of tramadol

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Rapid Detection of the C3435T Polymorphism of Multidrug Resistance Gene 1 Using Fluorogenic Hybridization Probes

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Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and susceptibility to idiopathic generalized epilepsy

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Interactions between fluoxetine and opiate analgesia for postoperative dental pain

1994 • 40 citations

Affinities of Dihydrocodeine and its Metabolites to Opioid Receptors

2002 • 39 citations

A pilot evaluation of alfentanil‐induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans

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Novel Polymorphism in the Gene Region Encoding the Carboxyl-Terminal Intracellular Domain of the NMDA Receptor 2B Subunit: Analysis of Association With Schizophrenia

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Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats

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Influence of L-tryptophan on morphine analgesia, tolerance and physical dependence.

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d-Morphine, but not l-morphine, has low micromolar affinity for the non-competitive N-methyl-d-aspartate site in rat forebrain. Possible clinical implications for the management of neuropathic pain

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Morphine‐Fluoxetine Interactions in Healthy Volunteers: Analgesia and Side Effects

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Cytochrome P450 2D6 and Treatment of Codeine Dependence

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Perioperative Dextromethorphan Reduces Postoperative Pain After Hysterectomy

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Analgesic and immunomodulatory effects of codeine and codeine 6-glucuronide.

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Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

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Antinociceptive effects of morphne-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

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Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse

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Enhancement of morphine analgesia by fenfluramine in subjects receiving tailored opioid infusions

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Differential antinociception by morphine and methadone in two sub-strains of Sprague–Dawley rats and its potentiation by dextromethorphan

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A dimensional impulsive‐aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: A pilot study in well‐characterized impulsive inpatients

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Association analysis of polymorphisms in the mu opioid gene and heroin abuse in Chinese subjects

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GLUCURONIDATION OF DIHYDROCODEINE BY HUMAN LIVER MICROSOMES AND THE EFFECT OF INHIBITORS

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Localization of the Kappa Opioid Receptor Gene to Human Chromosome Band 8q11.2

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The N-methyl-d-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord

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Variant detection at the δ opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence

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Mutation analysis of the N-methyl-d-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia

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Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery

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Cyclooxygenase-2 Polymorphism

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Dextromethorphan Reduces Immediate and Late Postoperative Analgesic Requirements and Improves Patients’ Subjective Scorings After Epidural Lidocaine and General Anesthesia

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G Protein β3 Gene Variant, Vascular Function, and Insulin Sensitivity in Type 2 Diabetes

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Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser

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Potentiation of κ-opioid receptor agonist-induced analgesia and hypothermia by fluoxetine

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Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours

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Rifampin-induced methadone withdrawal in AIDS.

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Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.

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The opioid receptor system and alcoholism: a genetic perspective

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Functionally gene-linked polymorphic regions and genetically controlled neurotransmitters metabolism

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Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome

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Alcohol Consumption Alters the Pharmacodynamics of Alfentanil

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The effect of codeine on gastrointestinal transit in extensive and poor metabolisers of debrisoquine

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Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.

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A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans

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Dextromethorphan Reduces Immediate and Late Postoperative Analgesic Requirements and Improves Patients’ Subjective Scorings After Epidural Lidocaine and General Anesthesia

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Association studies of the HOPA dodecamer duplication variant in different subtypes of autism

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Metabolic and Ethnic Determinants of Alcohol Drinking Habits and Vulnerability to Alcohol-Related Disorder

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The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats

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Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease.

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Purification and Characterization of Two Major Forms of Naloxone Reductase from Rabbit Liver Cytosol, New Members of Aldo-Keto Reductase Superfamily.

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Prolongation of morphine anaesthesia in a patient with Gilbert's disease: Report of a case

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A sex difference in the effects of oral codeine and promethazine on the ventilatory response to carbon dioxide in human volunteers.

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Gender differences in response to drugs: pain medications.

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Effect of Fluvoxamine on Sufentanil Antinociception and Tolerance under Chronic Intravenous Infusion in Rats

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Investigation of racial variations in the metabolism of tramadol

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Purification and characterization of rat liver naloxone reductase that is identical to 3alpha-hydroxysteroid dehydrogenase

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Potentiation of morphine analgesia after pretreatment with probenecid or sulfinpyrazone

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Ethnic Differences of the Primary Gene Defect at the Cytochrome P-450 2D6

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[Opioid receptor interactions of butorphanol, a narcotic antagonist analgesic, and its metabolites].

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N-Methyl-D-Aspartate Receptor Channel Block by Meperidine Is Dependent on Extracellular pH

2000 • 4 citations

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1983 • 4 citations

N-Methyl-D-Aspartate Receptor Channel Block by Meperidine Is Dependent on Extracellular pH

2000 • 3 citations

Pain thresholds and serotonin receptor 2A gene polymorphism in schizophrenic families

2002 • 2 citations