Paroxetine Increases Steady-State Concentrations of (R)-Methadone in CYP2D6 Extensive but Not Poor Metabolizers

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1998 • 820 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

1996 • 314 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

A 2.5-Year Follow-up of Depression, Life Crises, and Treatment Effects on Abstinence Among Opioid Addicts

1986 • 234 citations

Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver Microsomes

1996 • 225 citations

Pharmacokinetic-Pharmacodynamic Relationship of the Selective Serotonin Reuptake Inhibitors???

1996 • 212 citations

Ultrarapid metabolizers of debrisoquine: Characterization and PCR‐based detection of alleles with duplication of the CYP2D6 gene

1996 • 198 citations

Methadone N‐demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

1999 • 180 citations

Inhibition of Alprazolam and Desipramine Hydroxylation In Vitro by Paroxetine and Fluvoxamine

1995 • 174 citations

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.

1997 • 134 citations

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

2001 • 114 citations

Simultaneous Determination of Human Plasma Levels of Citalopram, Paroxetine, Sertraline, and Their Metabolites by Gas Chromatography--Mass Spectrometry

1998 • 112 citations

Phenacetin O -deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

1996 • 107 citations

Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment

2000 • 107 citations

Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method

1981 • 106 citations

Human Cytochromes and Some Newer Antidepressants: Kinetics, Metabolism, and Drug Interactions

1999 • 98 citations

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

1996 • 96 citations

Disposition of methadone in methadone maintenance

1975 • 96 citations

Probable Metabolic Interaction Between Methadone and Fluvoxamine in Addict Patients

1994 • 85 citations

Fluvoxamine and Fluoxetine Do Not Interact in the Same Way With the Metabolism of the Enantiomers of Methadone

1997 • 82 citations