The hypoalgesic effect of tramadol in relation to CYP2D6*

Arzneimittelforschung

2005 • 8,820 citations

Analysis of serial measurements in medical research.

1990 • 3,078 citations

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

1992 • 1,138 citations

Tramadol

1993 • 538 citations

Tramadol: pain relief by an opioid without depression of respiration

1992 • 448 citations

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

1993 • 429 citations

INTRODUCTION

1982 • 390 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Statistics in Medicine: Calculating confidence intervals for some non-parametric analyses

1988 • 314 citations

Measurements of human pressure-pain thresholds on fingers and toes

1989 • 293 citations

Multiple opioid systems and pain

1986 • 286 citations

Contribution of monoaminergic modulation to the analgesic effect of tramadol

1996 • 244 citations

Interaction of the central analgesic, tramadol, with the uptake and release of 5‐hydroxytryptamine in the rat brain in vitro

1992 • 241 citations

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1996 • 238 citations

Abuse potential and pharmacological comparison of tramadol and morphine

1991 • 235 citations

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

1988 • 210 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1984 • 185 citations

[Biotransformation of tramadol in man and animal (author's transl)].

1981 • 142 citations

Codeine O‐demethylation co‐segregates with polymorphic debrisoquine hydroxylation.

1989 • 139 citations

The metabolism of tramadol by human liver microsomes

1992 • 135 citations

Morphine and ibuprofen compared using the cold pressor test

1988 • 121 citations

Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat

1992 • 115 citations

Pain and hyperalgesia following tissue injury: new mechanisms and new treatments

1991 • 81 citations

The hypoalgesic effect of imipramine in different human experimental pain models

1995 • 73 citations

Sparteine Oxidation Polymorphism in Denmark

1985 • 68 citations

[Duality of the analgesic effect of tramadol in humans].

1993 • 57 citations

Determination of tramadol in human serum by capillary gas chromatography with nitrogen-selective detection

1986 • 55 citations

[Pharmacological studies on analgesia, dependence on and tolerance of tramadol, a potent analgetic drug (author's transl)].

1978 • 40 citations

Ondansetron does not inhibit the analgesic effect of alfentanil

1994 • 28 citations

Studies on the cutaneous pricking pain threshold in man. Circadian and circatrigintan changes.

1970 • 24 citations

[On separation of isomeres, structural elucidation and pharmacological characterization of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (author's transl)].

1978 • 23 citations

[Clinical study on the development of dependency after long-term treatment with tramadol (author's transl)].

1978 • 23 citations

Antidepressants in the treatment of diabetic neuropathy symptoms. Pharmacodynamic, -kinetic, and -genetic aspects.

1994 • 18 citations

[The effect of tramadol, a new analgesic, on respiration and cardiovascular function (author's transl)].

1978 • 14 citations