The Sequence of the Human Genome

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Basic local alignment search tool

1990 • 87,358 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Emergence of Scaling in Random Networks

1999 • 34,466 citations

Molecular Evolutionary Genetics

1987 • 15,266 citations

The Pfam protein families database.

2002 • 14,298 citations

Identification of common molecular subsequences

1981 • 9,753 citations

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

2000 • 8,948 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

Base-Calling of Automated Sequencer Traces UsingPhred. I. Accuracy Assessment

1998 • 6,925 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

1995 • 5,571 citations

Base-Calling of Automated Sequencer Traces Using Phred. II. Error Probabilities

1998 • 5,382 citations

Life with 6000 Genes

1996 • 4,125 citations

An introduction to population genetics theory

1970 • 4,120 citations

The COG database: a tool for genome-scale analysis of protein functions and evolution

2000 • 4,098 citations

Prediction of complete gene structures in human genomic DNA

1997 • 4,041 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

The complete genome sequence of the gastric pathogen Helicobacter pylori

1997 • 3,529 citations

An Introduction to Population Genetics Theory

1971 • 3,490 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

1999 • 3,156 citations

The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

2000 • 2,834 citations

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes

2000 • 2,628 citations

The Minimal Gene Complement of Mycoplasma genitalium

1995 • 2,499 citations

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project

1991 • 2,286 citations

Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

1998 • 2,163 citations

Nucleotide sequence of bacteriophage G4 DNA

1978 • 2,137 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

A Whole-Genome Assembly of Drosophila

2000 • 1,532 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Nucleotide sequence of bacteriophage φX174 DNA

1977 • 1,475 citations

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

1997 • 1,417 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

The Pfam Protein Families Database

2000 • 1,235 citations

Pfam: A comprehensive database of protein domain families based on seed alignments

1997 • 1,211 citations

CONNEXINS, CONNEXONS, AND INTERCELLULAR COMMUNICATION

1996 • 1,180 citations

Nucleotide sequence of bacteriophage λ DNA

1982 • 1,171 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

2000 • 1,098 citations

Ab initio Gene Finding in Drosophila Genomic DNA

2000 • 1,095 citations

Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in Recombination

1998 • 1,092 citations

Complete Genome Sequence of Treponema pallidum , the Syphilis Spirochete

1998 • 1,060 citations

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

2000 • 1,024 citations

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

1999 • 1,023 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

Inferring statistical complexity

1989 • 984 citations

Genomic mapping by fingerprinting random clones: A mathematical analysis

1988 • 955 citations

Alignment of whole genomes

1999 • 918 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

A System for Rapid DNA Sequencing with Fluorescent Chain-Terminating Dideoxynucleotides

1987 • 852 citations

New Goals for the U.S. Human Genome Project: 1998-2003

1998 • 848 citations

Regenerating the damaged central nervous system

2000 • 824 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy

1998 • 797 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence

1998 • 745 citations

An SNP map of the human genome generated by reduced representation shotgun sequencing

2000 • 734 citations

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

1999 • 713 citations

Specificities of heparan sulphate proteoglycans in developmental processes

2000 • 706 citations

TELOMERES AND THEIR CONTROL

2000 • 706 citations

CpG islands as gene markers in the vertebrate nucleus

1987 • 687 citations

Regulated Diversity of Heparan Sulfate

1998 • 671 citations

The Syntenic Relationship of the Zebrafish and Human Genomes

2000 • 626 citations

Line-of-descent and genealogical processes, and their applications in population genetics models

1984 • 625 citations

Mice lacking vimentin develop and reproduce without an obvious phenotype

1994 • 603 citations

A general approach to single-nucleotide polymorphism discovery

1999 • 564 citations

Isochores and the evolutionary genomics of vertebrates

2000 • 555 citations

The Distribution of Human Genetic Diversity: A Comparison of Mitochondrial, Autosomal, and Y-Chromosome Data

2000 • 532 citations

DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

1998 • 485 citations

ADAMs: focus on the protease domain

1998 • 472 citations

CpG islands and genes

1995 • 449 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

Haplotype Structure and Population Genetic Inferences from Nucleotide-Sequence Variation in Human Lipoprotein Lipase

1998 • 439 citations

The pattern of neutral molecular variation under the background selection model.

1995 • 431 citations

Requirement of the RNA Editing Deaminase ADAR1 Gene for Embryonic Erythropoiesis

2000 • 418 citations

Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid

1999 • 412 citations

The domains of death: evolution of the apoptosis machinery

1999 • 406 citations

High Throughput Fingerprint Analysis of Large-Insert Clones

1997 • 405 citations

Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease

2000 • 402 citations

Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome

1999 • 388 citations

The role of the 5′ untranslated region of an mRNA in translation regulation during development

1999 • 369 citations

Analysis of expressed sequence tags indicates 35,000 human genes

2000 • 367 citations

Shotgun Sequencing of the Human Genome

1998 • 363 citations

Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library

1993 • 361 citations

PowerBLAST: A New Network BLAST Application for Interactive or Automated Sequence Analysis and Annotation

1997 • 356 citations

A new strategy for genome sequencing

1996 • 349 citations

Gene expression in rat brain

1983 • 344 citations

A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase.

1991 • 332 citations

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1999 • 325 citations

Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence

2000 • 324 citations

Human Whole-Genome Shotgun Sequencing

1997 • 320 citations

Chromosome bands, their chromatin flavors, and their functional features.

1992 • 316 citations

Association of Neuronal Calcium Channels with Modular Adaptor Proteins

1999 • 315 citations

Protein Crosslinking in Assembly and Remodelling of Extracellular Matrices: The Role of Transglutaminases

2000 • 314 citations

EST comparison indicates 38% of human mRNAs contain possible alternative splice forms

2000 • 303 citations

Molecular basis of semaphorin-mediated axon guidance

2000 • 300 citations

3,400 new expressed sequence tags identify diversity of transcripts in human brain

1993 • 292 citations

The dynamics of chromosome evolution in birds and mammals

1999 • 292 citations

Adjusting the focus on human variation

2000 • 278 citations

Information measures, effective complexity, and total information

1996 • 273 citations

Specific-primer-directed DNA sequencing

1986 • 264 citations

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

1998 • 260 citations

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI

2000 • 247 citations

Tyrosine sulfation: a modulator of extracellular protein–protein interactions

2000 • 245 citations

DNA sequence variation in a non-coding region of low recombination on the human X chromosome

1999 • 242 citations

Internal ribosome initiation of translation and the control of cell death

2000 • 241 citations

Identification of Paracaspases and Metacaspases

2000 • 233 citations

MIRs are classic, tRNA-derived SINEs that amplified before the mammalian radiation

1995 • 226 citations

Eph receptors and ephrins: Regulators of guidance and assembly

2000 • 217 citations

Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes

1998 • 213 citations

Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase

1991 • 204 citations

DNA Variability and Recombination Rates at X-Linked Loci in Humans

1998 • 204 citations

The gene distribution of the human genome

1996 • 199 citations

ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases

1999 • 198 citations

Digitized and differentially shaded human chromosome ideograms for genomic applications

1994 • 187 citations

Sequence Diversity and Large-Scale Typing of SNPs in the Human Apolipoprotein E Gene

2000 • 183 citations

Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

1987 • 181 citations

Overlapping Genomic Sequences: A Treasure Trove of Single-Nucleotide Polymorphisms

1998 • 168 citations

Genetic Expression in the Developing Brain

1983 • 167 citations

Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides

2000 • 166 citations

A Map of 75 Human Ribosomal Protein Genes

1998 • 166 citations

The question remains: is the spliceosome a ribozyme?

2000 • 163 citations

Eukaryote genome duplication - where's the evidence?

1998 • 163 citations

Mammalian chromosome banding — an expression of genome organization

1989 • 161 citations

Nature and Structure of Human Genes that Generate Retropseudogenes

2000 • 159 citations

Lessons from metabolic engineering for functional genomics and drug discovery

1999 • 158 citations

Against a Whole-Genome Shotgun

1997 • 157 citations

Cell cycle regulation of the glyceraldehyde3phosphate dehydrogenaseluracil DNA glycosylase gene in normal human cells

1993 • 157 citations

A High-Resolution Radiation Hybrid Map of the Human Genome Draft Sequence

2001 • 153 citations

The lethal mutation of the mouse wasted ( wst ) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1α, encoded by the Eef1a2 gene

1998 • 152 citations

Noncoding RNA genes

1999 • 149 citations

Ribosomal Proteins in Cell Proliferation and Apoptosis

1999 • 147 citations

Neurotrophins in Cell Survival/Death Decisions

1999 • 146 citations

Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca2+-dependent manner

1995 • 138 citations

[16] Discovering and understanding genes in human DNA sequence using GRAIL

1996 • 136 citations

Heterochromatin and satellite DNA in man: properties and prospects.

1979 • 132 citations

Primate Evolution of an Olfactory Receptor Cluster: Diversification by Gene Conversion and Recent Emergence of Pseudogenes

1999 • 124 citations

An encyclopedia of mouse genes

1999 • 120 citations

The molecular genetics of myelination: An update

1993 • 116 citations

Up a Notch

2000 • 114 citations

The Mosaic Structure of Human Pericentromeric DNA: A Strategy for Characterizing Complex Regions of the Human Genome

2000 • 105 citations

Electronic PCR: bridging the gap between genome mapping and genome sequencing

1998 • 100 citations

Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes

2000 • 92 citations

A Set of Highly Conserved RNA-binding Proteins, αCP-1 and αCP-2, Implicated in mRNA Stabilization, Are Coexpressed from an Intronless Gene and Its Intron-containing Paralog

1999 • 92 citations

Estimation of Synteny Conservation and Genome Compaction Between Pufferfish (Fugu) and Human

2000 • 81 citations

An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene

2000 • 79 citations

Efficient Approach to Unique Single-Nucleotide Polymorphism Discovery

1999 • 73 citations

Chromosomal distribution of 320 genes from a brain cDNA library

1993 • 67 citations

DNA Methylation, Genomic Imprinting and Cancer

2000 • 65 citations

Retropseudogenes constitute the major part of the human elongation factor 1α gene family

1990 • 54 citations

Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3

1992 • 48 citations

Molecules and cognition: The latterday lessons of levels, language, and iac. Evolutionary overview of brain structure and function in some vertebrates and invertebrates

1993 • 47 citations

Human BAC Ends Quality Assessment and Sequence Analyses

2000 • 45 citations

A model for high-throughput automated DNA sequencing and analysis core facilities

1994 • 45 citations

A quality control algorithm for DNA sequencing projects

1993 • 44 citations

Dispensable genes

1985 • 44 citations

Nuclear DNA Content and Morphology of the Karyotype in Certain Palearctic Microchiroptera

1971 • 41 citations

Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels

2000 • 40 citations

Data transferability from model organisms to human beings: Insights from the functional genomics of the flightless region of Drosophila

1998 • 38 citations

The Santa Cruz Workshop—May 1985

1989 • 38 citations

Concerted evolution in the GAPDH family of retrotransposed pseudogenes

1993 • 34 citations

Hubris and the Human Genome

1998 • 32 citations

The mammalian genome shaping activity of reverse transcriptase

1994 • 30 citations

CpG island libraries from human Chromosomes 18 and 22: landmarks for novel genes

2000 • 28 citations

Retrotransposition of Glycerol Kinase-Related Genes from the X Chromosome to Autosomes: Functional and Evolutionary Aspects

1999 • 25 citations

Progressive Multiple Alignment with Constraints

1996 • 24 citations

Gene estimate rises as US and UK discuss freedom of access

1999 • 23 citations

Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21

2000 • 21 citations

Toxin injury-dependent switched expression between EF-1? and its sister, S1, in rat skeletal muscle

1999 • 15 citations

Sequencing and analysis of genomic fragments from theNF1locus

1992 • 14 citations

[5] Current status of computational gene finding: A perspective

1999 • 13 citations

Framework for a Physical Map of the Human 22q13 Region Using Bacterial Artificial Chromosomes (BACs)

1996 • 13 citations

Improvements in the chain-termination method of DNA sequencing through the use of 7-deaza-2′-deoxyadenosine

1991 • 13 citations

Is Whole Human Genome Sequencing Feasible?

1997 • 8 citations

Imprinting: silently crossing the boundary.

2000 • 7 citations

Nucleotide sequence of a human gene coding for a polypeptide hormone.

1977 • 5 citations

On the equality of origin and fixation times in genetics

1987 • 5 citations

Strahlenresistenz, Gehalt und Basenzusammensetzung der DNA einiger strahleninduzierter Mutanten von Azotobacter chroococcum

1967 • 3 citations

HUMAN GENOME PROJECT: Funders Reassure Genome Sequencers

1998 • 3 citations

[Radiation resistance, content and base composition of DNA in some radiation-induced mutants of Azotobacter chroococcum].

1967 • 3 citations