The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

1989 • 5,285 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

Variations on a Theme: Cataloging Human DNA Sequence Variation

1997 • 1,064 citations

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

1998 • 1,055 citations

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

1997 • 511 citations

mu opiate receptor: cDNA cloning and expression.

1993 • 405 citations

Opiate receptor binding sites in human brain

1982 • 302 citations

Human μ opiate receptor

1994 • 286 citations

μ opioid receptor gene variants: lack of association with alcohol dependence

1997 • 278 citations

Mu‐opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy

1988 • 227 citations

Multicompartmental Analysis of [¹¹C]-Carfentanil Binding to Opiate Receptors in Humans Measured by Positron Emission Tomography

1989 • 194 citations

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

1994 • 181 citations

Opiate receptors in mice: Genetic differences

1975 • 171 citations

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.

1996 • 154 citations

Familial typical migraine

1998 • 144 citations

Pharmacology and regulation of the neuronal dopamine transporter

1997 • 139 citations

Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

The μ-opioid receptor is necessary for [d-Pen2,d-Pen5]enkephalin-induced analgesia

1997 • 126 citations

Identification of a Sex-Specific Quantitative Trait Locus Mediating Nonopioid Stress-Induced Analgesia in Female Mice

1997 • 121 citations

Migraine in Twins Raised Together and Apart

1998 • 106 citations

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

1995 • 101 citations

Analgesic, locomotor and lethal effects of morphine in the mouse: Strain comparisons

1985 • 84 citations

The human µ opioid receptor gene: 5´ regulatory and intronic sequences

1998 • 83 citations

Characterization of the Murine μ Opioid Receptor Gene

1995 • 80 citations

Longitudinal genetic analysis of menstrual flow, pain, and limitation in a sample of Australian twins.

1998 • 65 citations

Examination of the involvement of supraspinal and spinal mu and delta opioid receptors in analgesia using the mu receptor deficient CXBK mouse.

1988 • 62 citations

Dual Promoters of Mouse μ-Opioid Receptor Gene1

1997 • 62 citations

Visceral chemical nociception in mice lacking μ-opioid receptors: effects of morphine, SNC80 and U-50,488

1999 • 58 citations

A study of oral morphine preference in inbred mouse strains

1994 • 34 citations

Transcription of the mouse μ-opioid receptor gene is regulated by two promoters

1997 • 25 citations

Genetic basis of migraine.

1998 • 22 citations

Genetic analyses of complex behavioral disorders

1997 • 20 citations