Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

A Sensitive Fluorimetric Assay for Serum Angiotensin-con venrting Enzyme

1976 • 462 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Functional involvement of P-glycoprotein in blood-brain barrier.

1992 • 352 citations

Isolation of metabolically active capillaries from rat brain^1,2

1975 • 316 citations

Kinetic analysis of blood-brain barrier transport of amino acids

1975 • 306 citations

Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models

1992 • 289 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

The analgesic activity of morphine‐6‐glucuronide.

1992 • 272 citations

Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier.

1990 • 263 citations

Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

1986 • 246 citations

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

1994 • 243 citations

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity

1991 • 211 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

Physiology and Pharmacology of the Blood-Brain Barrier

1992 • 199 citations

Oral morphine in cancer pain: influences on morphine and metabolite concentration

1990 • 163 citations

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells

1993 • 142 citations

Biochemical basis for analgesic activity of morphine-6-glucuronide—I

1973 • 135 citations

Respiratory depression following morphine and morphine-6-glucuronide in normal subjects.

1995 • 100 citations

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

1990 • 97 citations

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

1994 • 82 citations

Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

1992 • 48 citations

Renal tubular transport of morphine, morphine-6-glucuronide, and morphine-3-glucuronide in the isolated perfused rat kidney.

1991 • 45 citations

Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chromatography

1995 • 40 citations

17 beta-estradiol glucuronide: an inducer of cholestasis and a physiological substrate for the multidrug resistance transporter.

1993 • 39 citations

Uptake of leucine and alanine by cultured cerebral capillary endothelial cells

1989 • 39 citations

Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression.

1994 • 33 citations

P-glycoprotein of blood brain barrier: cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries

1995 • 27 citations

Drug Transfer Across the Blood-Brain Barrier: Comparison of in Vitro and in Vivo Models

1993 • 10 citations