Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception.

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

1994 • 593 citations

Pharmacological Mechanisms of Opioid Analgesics

1993 • 559 citations

Cloning and pharmacological characterization of a rat μ opioid receptor

1993 • 460 citations

mu opiate receptor: cDNA cloning and expression.

1993 • 405 citations

cDNA cloning and regional distribution of a novel member of the opioid receptor family

1994 • 404 citations

cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

1994 • 379 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Molecular biology of opioid receptors

1993 • 358 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

An opiate-receptor gene family reunion

1994 • 286 citations

Human μ opiate receptor

1994 • 286 citations

Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose

1973 • 279 citations

Primary structures and expression from cDNAs of rat opioid receptor δ‐and μ‐subtypes

1993 • 277 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors

1994 • 254 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Molecular biology and pharmacology of cloned opioid receptors ¹

1995 • 231 citations

I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat

1986 • 212 citations

Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor

1994 • 192 citations

Morphine-6-glucuronide: Analgesic effects and receptor binding profile in rats

1988 • 191 citations

Antisense mapping the MOR‐1 opioid receptor: evidence for alternative splicing and a novel morphine‐6β‐glucuronide receptor

1995 • 181 citations

Expression of two variants of the human μ opioid receptor mRNA in SK‐N‐SH cells and human brain

1994 • 172 citations

Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology

1995 • 170 citations

Naloxazone, a long-acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro.

1980 • 170 citations

Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene.

1994 • 166 citations

Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor.

1995 • 150 citations

Role of μ1-opiate receptors in supraspinal opiate analgesia: a microinjection study

1988 • 119 citations

μ and δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla

1994 • 117 citations

Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor

1994 • 110 citations

Cloning of a human κ opioid receptor from the brain

1995 • 100 citations

Differential blockade of morphine and morphine-6β-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein α subunits in rats

1995 • 98 citations

The application of antisense oligonucleotide technology to the brain: Some pitfalls

1994 • 91 citations

Cloning, Characterization, and Distribution of a μ-Opioid Receptor in Rat Brain

1994 • 90 citations

The spinal antinociceptive actions of morphine metabolites morphine-6-glucuronide and normorphine in the rat

1989 • 78 citations

Synergistic brainstem interactions for morphine analgesia

1993 • 72 citations

Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ2-agonist antinociception

1994 • 72 citations

Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a κ-opioid receptor

1994 • 71 citations

The μ opiate receptor is responsible for descending pain inhibition originating in the periaqueductal gray region of the rat brain

1988 • 64 citations

Cloning, expression and classification of a kappa3-related opioid receptor using antisense oligodeoxynucleotides

1994 • 63 citations

Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor

1994 • 55 citations

Antisense oligodeoxynucleotide to a δ-opioid receptor selectivily blocks the spinal antinociception induced by δ-, but not μ- or κ-opioid receptor agonists in the mouse

1994 • 54 citations

Murine Chromosomal Location of the μ and κ Opioid Receptor Genes

1994 • 53 citations

Isolation of cDNA clones homologous to opioid receptors

1994 • 46 citations

An antisense oligodeoxynucleotide to μ-opioid receptors inhibits μ-opioid receptor agonist-induced analgesia in rats

1995 • 44 citations

Intracerebroventricular treatment with an antisense oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats

1994 • 42 citations

Antisense Oligodeoxynucleotides to the Cloned δ Receptor DOR‐1: Uptake, Stability, and Regulation of Gene Expression

1995 • 42 citations

Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus

1990 • 35 citations

Structure and Expression of a Rat κ Opioid Receptor Gene

1995 • 30 citations

Antisense Vasopressin Oligonucleotides: Uptake, Turnover, Distribution, Toxicity and Behavioral Effects

1995 • 27 citations

Cloning and expression of an isoform of the rmu-opioid receptor (rmuOR1B)

1994 • 25 citations

Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal, antinociceptive effects of [D-Ala2, Glu4]deltorphin

1994 • 6 citations