Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

A potent and selective endogenous agonist for the µ-opiate receptor

1997 • 1,306 citations

Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

1998 • 1,055 citations

Addictive Drugs and Brain Stimulation Reward

1996 • 777 citations

Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm

1996 • 578 citations

Pharmacological Mechanisms of Opioid Analgesics

1993 • 559 citations

Sequence variability and candidate gene analysis in complex disease: association of micro opioid receptor gene variation with substance dependence

2000 • 291 citations

μ opioid receptor gene variants: lack of association with alcohol dependence

1997 • 278 citations

Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

1999 • 245 citations

The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

1999 • 204 citations

Detection of Single-Nucleotide Polymorphisms with the WAVE™ DNA Fragment Analysis System

1997 • 152 citations

Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence.

2001 • 122 citations

An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA

1995 • 116 citations

Opioid receptors: Some perspectives from early studies of their role in normal physiology, stress responsivity, and in specific addictive diseases

1996 • 89 citations

Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse

1997 • 77 citations

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

1998 • 66 citations

Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.

1992 • 28 citations