The genetic mediation of individual differences in sensitivity to pain and its inhibition

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1995 • 5,291 citations

Genetic Dissection of Complex Traits

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Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

1996 • 2,308 citations

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

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Genetic variants and strains of the laboratory mouse

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Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy.

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Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction

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A twin-pronged attack on complex traits

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Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

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Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis

1996 • 622 citations

RECOMBINANT-INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES

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The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

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Pharmacological Mechanisms of Opioid Analgesics

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RECOMBINANT INBRED STRAINS: USE IN GENE MAPPING

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Estimation of Genetic Correlation: Interpretation of Experiments Using Selectively Bred and Inbred Animals

1990 • 322 citations

Measurements of human pressure-pain thresholds on fingers and toes

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Naloxone alters pain perception and somatosensory evoked potentials in normal subjects

1977 • 287 citations

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Hypertension-Associated Hypalgesia

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Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement

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Human pain responsivity in a tonic pain model: Psychological determinants

1989 • 252 citations

Individual variability in the response to different opioids: report of five cases

1992 • 245 citations

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1996 • 238 citations

Heritability of nociception II. ‘Types’ of nociception revealed by genetic correlation analysis

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Identification of sex–specific quantitative trait loci controlling alcohol preference in C57BL/6 mice

1996 • 188 citations

Migraine and Concomitant Symptoms Among 8167 Adult Twin Pairs

1995 • 187 citations

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

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Heritability of symptoms in an experimental model of neuropathic pain

1990 • 178 citations

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.

1996 • 175 citations

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

1991 • 171 citations

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Sex differences in supraspinal morphine analgesia are dependent on genotype.

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Sex differences in opioid antinociception.

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The genetics of pain and pain inhibition.

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Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests

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Analgesic responses to morphine and placebo in individuals with postoperative pain

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Genetic Influence in Headaches: A Swedish Twin Study

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Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

Familial pain models: the relationship between family history of pain and current pain experience

1985 • 135 citations

CONGENITAL INSENSITIVITY TO PAIN

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Topographic brain measures of human pain and pain responsivity

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Anatomical evidence for genetic differences in the innervation of the rat spinal cord by noradrenergic locus coeruleus neurons

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Handbook of Psychiatric Genetics

1996 • 125 citations

Familial models for chronic pain

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Transgenic studies of pain

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Identification of a Sex-Specific Quantitative Trait Locus Mediating Nonopioid Stress-Induced Analgesia in Female Mice

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The gene for hereditary sensory neuropathy type I (HSN–I) maps to chromosome 9q22.1–q22.3

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THE OPTIMAL DOSE OF MORPHINE

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Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2-opioid receptors

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Profile of Caucasian Women with Possible Genetic Predisposition to Reflex Sympathetic Dystrophy

1994 • 110 citations

Strain Differences in Autotomy in Rats Undergoing Sciatic Nerve Transection or Repair

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Migraine in Twins Raised Together and Apart

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Association between a delta opioid receptor gene polymorphism and heroin dependence in man

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Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

1995 • 101 citations

Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.

1993 • 101 citations

Genetic and Environmental Factors in Sciatica Evidence from a Nationwide Panel of 9365 Adult Twin Pairs

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Inheritance of stress-induced analgesia in mice. Selective breeding study

1986 • 97 citations

A genetic analysis of the response to morphine in mice: Analgesia and running

1975 • 94 citations

Determinants of pressure pain threshold in adult twins: evidence that shared environmental influences predominate

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Evidence for an X-linked genetic component in familial typical migraine

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Pain in Young Adults

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Short‐term reproducibility of pressure pain thresholds in masseter and temporalis muscles of symptom‐free subjects

1997 • 90 citations

Sex and Genotype Determine the Selective Activation of Neurochemically-Distinct Mechanisms of Swim Stress-Induced Analgesia

1997 • 90 citations

Differential Effects of Prenatal Stress in Two Inbred Strains of Rats

1998 • 89 citations

The human µ opioid receptor gene: 5´ regulatory and intronic sequences

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Familial Predisposition to Discogenic Low-Back Pain

1988 • 83 citations

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

1993 • 83 citations

Genetic influences in opioid analgesic sensitivity in mice

1991 • 80 citations

Chromosome Mapping of Gene Loci Affecting Morphine and Amphetamine Responses in BXD Recombinant Inbred Micea

1992 • 79 citations

Sex differences in N-methyl-d-aspartate involvement in κ opioid and non-opioid predator-induced analgesia in mice

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Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse

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Individual differences in pain thresholds.

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Relationship between Superficial and Deep Somatic Thresholds of Pain with a Note on Handedness

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The influence of pharmacogenetics on opioid analgesia: studies with codeine and oxycodone in the Sprague-Dawley/Dark Agouti rat model.

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Opioids and behavior: genetic aspects

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Serotonin receptors and their ligands: A lack of selective agents

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Response of experimental pain to analgesic drugs: I. Morphine, aspirin, and placebo

1966 • 66 citations

Longitudinal genetic analysis of menstrual flow, pain, and limitation in a sample of Australian twins.

1998 • 65 citations

Profiles of opioid analgesia in humans after intravenous bolus administration: alfentanil, fentanyl and morphine compared on experimental pain

1990 • 63 citations

Lack of morphine and enkephalin tolerance in 129/SvEv mice: evidence for a NMDA receptor defect.

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Relationship between hypothalamic-pituitary-adrenal activity and blockade of tolerance to morphine analgesia by pain: a strain comparison

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Selective breeding for high and low levels of opiate-induced analgesia in mice

1983 • 58 citations

Genetic differences in morphine sensitivity, tolerance and withdrawal in rats

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Strain differences in adrenergic sensitivity of neuropathic pain behaviors in an experimental rat model

1997 • 58 citations

Influence of nerve lesions, strain differences and continuous cold stress on chronic pain behavior in rats

1981 • 55 citations

The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains

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The molecular basis of genetic polymorphisms of drug metabolism.

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Rat strain differences in the potentiation of morphine-induced analgesia by stress

1995 • 53 citations

Endocrine influences on the actions of morphine: IV. effects of sex and strain

1984 • 53 citations

Individual Pain History and Familial Pain Tolerance Models

1993 • 52 citations

Autotomy prevention by amitriptyline after peripheral nerve section in different strains of mice

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The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence development in two strains of rats

1974 • 49 citations

A comparative study of the Lewis and Sprague Dawley rat in adjuvant arthritis.

1970 • 49 citations

Studies of Genetic Differences in Response to Opioid Drugs

1991 • 48 citations

Footshock-induced analgesia: Its opioid nature depends on the strain of rat

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Genetically determined differences in the effects of morphine on mice

1975 • 47 citations

Back Pain: A Study of Twins

1991 • 47 citations

Codeine o-demethylation: Rat strain differences and the effects of inhibitors

1991 • 45 citations

Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice to produce antinociception.

1991 • 44 citations

Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity.

1999 • 42 citations

Are Tender Point Scores Assessed by Manual Palpation in Fibromyalgia Reliable?:An investigation into the variance of tender point scores

1995 • 41 citations

Systemic administration of naloxone produces analgesia in BALB/c mice in the formalin pain test

1988 • 40 citations

Histocompatability antigens in the fibrositis (fibromyalgia) syndrome.

1986 • 40 citations

Neuroendocrine, biogenic amine and behavioral responsiveness to a repeated foot-shock-induced analgesia (FSIA) stressor in Sprague-Dawley (CD) and Fischer-344 (CDF) rats

1986 • 39 citations

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1993 • 35 citations

Variability in the Pain Threshold

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Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine

1987 • 31 citations

Morphine analgesia, tolerance and dependence in mice from different strains and vendors

1977 • 30 citations

Sympathetically-maintained Causalgiform Disorders in a Model for Neuropathic Pain: A Review

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Rats with decreased brain cholecystokinin levels show increased responsiveness to peripheral electrical stimulation-induced analgesia

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Strain differences in reversal of conditional analgesia by opioid antagonists.

1987 • 27 citations

Pharmacogenetic variability in neuronal nicotinic receptor-mediated antinociception

1999 • 24 citations

Variations in cutaneous and deep somatic pain sensitivity.

1963 • 23 citations

Strain differences in the analgesic response to morphine as measured on the hot plate.

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Strain differences in reversal of conditional analgesia by opioid antagonists.

1987 • 23 citations

Genetic basis of migraine.

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Strain-dependent differences in responsiveness of mice to nitrous oxide (N2O) antinociception

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Genetic control of adjuvant-induced arthritis in rats

1971 • 20 citations

A YAC-Based Transcript Map of Human Chromosome 9q22.1–q22.3 Encompassing the Loci for Hereditary Sensory Neuropathy Type I and Multiple Self-Healing Squamous Epithelioma

1998 • 18 citations

Strain differences in autotomy levels in mice: relation to spinal excitability

1996 • 18 citations

Age, strain and anesthetic dependent differences in the nociceptive responses produced by i.v. 5-HT in the rat

1992 • 17 citations

Introductory Papers: Practical Aspects of Strain Variation in Relation to Pharmacological Testing

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Genetic influences on the control of nociceptive responses & precipitated abstinence in mice.

1982 • 17 citations

Sensitivity to Pain: (With an Analysis of 450 Cases).

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Strain differences in mice antinociception: relationship between alprazolam and opioid receptor subtypes

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Family History and Severity of Disability Associated with Chronic Low Back Pain

1985 • 13 citations

Exclusion of p75NGFR and other candidate genes in a family with hereditary sensory neuropathy Type II

1996 • 10 citations

Influence of psychogenetics in opiate tolerance and abstinence in mice

1991 • 9 citations

Analgesic effects of d-amino acids in four inbred strains of mice

1990 • 8 citations

Analgesic response in offspring of crosses between heroin ?? (Swiss Webster) and ?? (ICR) responding mice

1997 • 7 citations

Physiology And Pharmacology of Cardio-Respiratory Control

1998 • 7 citations

Inherited, selective hyporesponsiveness to the analgesic action of nicotine in mice

1996 • 6 citations

Sex Distinctiveness in Effective Genotype

2002 • 6 citations

[The modulating effect of the thyrotropin-releasing hormone on genetically induced mechanisms of morphine sensitivity].

1995 • 3 citations

[The genetic characteristics of the brain alpha 2-adrenergic and S2-serotoninergic systems in the realization of the tail-jerk pain reflex and its morphine suppression in rats].

1995 • 3 citations

Alternating versus synchronous ventilation of the two lungs

1998 • 1 citations