The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross‐over study with extensive and quinidine‐induced poor metabolizers

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Impact of environmental and genetic factors on codeine analgesia

1991 • 235 citations

Sex differences in responsiveness to painful and non-painful stimuli are dependent upon the stimulation method

1993 • 213 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

1990 • 193 citations

Differential effects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat

1976 • 185 citations

Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.

1991 • 129 citations

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

1986 • 113 citations

The effect of quinidine on the analgesic effect of codeine

1992 • 95 citations

Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.

1986 • 94 citations

Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment

1987 • 92 citations

Sparteine oxidation is practically abolished in quinidine‐treated patients.

1986 • 64 citations

Morphine formation from codeine in rat brain: A possible mechanism of codeine analgesia

1990 • 62 citations

Surgical pain is followed not only by spinal sensitization but also by supraspinal antinociception

1996 • 48 citations

Exploration of the metabolism of dihydrocodeine via determination of its metabolites in human urine using micellar electrokinetic capillary chromatography

1995 • 42 citations

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

1996 • 35 citations

Morphine does not affect laser induced warmth and pin prick pain thresholds

1994 • 33 citations

The postoperative pharmacokinetics of codeine

1992 • 28 citations

Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry

1995 • 25 citations

A comparison of the analgesic and respiratory effects of dihydrocodeine and morphine in man.

1958 • 21 citations

Characterization of the genetic polymorphism of dihydrocodeine O-demethylation in man via analysis of urinary dihydrocodeine and dihydromorphine by micellar electrokinetic capillary chromatography

1996 • 20 citations

Polymorphic metabolism of opioid narcotic drugs: possible clinical implications.

1991 • 20 citations

An Experimental and Statistical Method in the Study of New Drugs

1958 • 10 citations

Experimental contribution to the hypothesis of codeine smethylation in the body; influence of dose on habituation to codeine.

1948 • 6 citations

Electrokinetic Capillary Chromatography

1993 • 3 citations

Viscerocutaneous nociception and anorectal motor function: A prospective study in asymptomatic, healthy volunteers

1995 • 2 citations