The intrinsic antinociceptive effects of oxycodone appear to be κ -opioid receptor mediated

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

1994 • 630 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

1988 • 399 citations

Minireview: Multiple MU opiate receptors

1986 • 348 citations

Morphine-3-glucuronide - a potent antagonist of morphine analgesia

1990 • 341 citations

Application of the message-address concept in the design of highly potent and selective non-peptide .delta. opioid receptor antagonists

1988 • 298 citations

The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects.

1992 • 280 citations

Mu receptor binding of some commonly used opioids and their metabolites

1991 • 252 citations

Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes.

1994 • 226 citations

κ‐Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat

1988 • 198 citations

Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.

1988 • 194 citations

Pharmacokinetic-pharmacodynamic relationships of controlled-release oxycodone*

1996 • 185 citations

Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.

1982 • 164 citations

Morphine and Oxycodone in the Management of Cancer Pain: Plasma Levels Determined by Chemical and Radioreceptor Assays

1990 • 98 citations

Analgesic studies of codeine and oxycodone in patients with cancer. II. Comparisons of intramuscular oxycodone with intramuscular morphine and codeine.

1978 • 95 citations

Antinociceptive Effects and Central Nervous System Depression Caused by Oxycodone and Morphine in Rats

1992 • 86 citations

The influence of pharmacogenetics on opioid analgesia: studies with codeine and oxycodone in the Sprague-Dawley/Dark Agouti rat model.

1994 • 70 citations

Comparisons of the Analgesic Effects of Oral and Intramuscular Oxymorphone and of Intramuscular Oxymorphone and Morphine in Patients with Cancer

1977 • 65 citations

Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.

1991 • 63 citations

The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats

1994 • 55 citations

[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine

1988 • 55 citations

Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats.

1982 • 49 citations

Binding of [3H]naloxonazine to rat brain membranes.

1984 • 43 citations

Irreversible binding of [3H]β-funaltremaxine to brain slices of morphine-tolerant and -dependent mice

1988 • 6 citations

Mu antagonist and kappa agonist properties of b-funaltrexamine (b-FNA): long lasting spinal antinociception.

1989 • 5 citations