Glucuronidation in Humans

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

1998 • 669 citations

Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome

1996 • 593 citations

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

1992 • 473 citations

A Size Standard for Pharmacokinetics

1996 • 470 citations

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

1994 • 427 citations

Human UGT2B7 catalyzes morphine glucuronidation.

1997 • 416 citations

Clinical Pharmacokinetics in Newborns and Infants Age-related Differences and Therapeutic Implications

1980 • 388 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

Drug glucuronidation in humans

1991 • 357 citations

Chloramphenicol in the Newborn Infant

1960 • 352 citations

Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia

1997 • 340 citations

UDP-glucuronosyltransferases

1989 • 327 citations

The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches

1994 • 320 citations

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

1998 • 320 citations

STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES

1997 • 252 citations

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3.

1998 • 250 citations

The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver

1981 • 241 citations

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

1988 • 229 citations

CHRONIC UNCONJUGATED HYPERBILIRUBINEMIA WITHOUT OVERT SIGNS OF HEMOLYSIS IN ADOLESCENTS AND ADULTS*

1962 • 226 citations

Isolation and characterization of UGT2B15(Y85): a UDP glucuronosyltransferase encoded by a polymorphic gene

1997 • 223 citations

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

1993 • 222 citations

Specificity of human UDP-Glucuronosyltransferases and xenobiotic glucuronidation

1995 • 220 citations

Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports

1997 • 212 citations

Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family.

1993 • 207 citations

Size, Myths and the Clinical Pharmacokinetics of Analgesia in Paediatric Patients

1997 • 204 citations

Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein.

1996 • 202 citations

Fatal Cardiovascular Collapse of Infants Receiving Large Amounts of Chloramphenicol

1959 • 193 citations

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

1997 • 189 citations

Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids

1996 • 187 citations

Pharmacokinetics of Acetaminophen in the Human Neonate: Formation of Acetaminophen Glucuronide and Sulfate in Relation to Plasma Bilirubin Concentration and D-Glucaric Acid Excretion

1975 • 185 citations

Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety

1985 • 184 citations

Gilbert syndrome accelerates development of neonatal jaundice

1998 • 175 citations

Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes

1993 • 172 citations

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase.

1994 • 171 citations

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

1988 • 169 citations

Glucuronidation of Drugs

1992 • 162 citations

Glucuronidation and its Role in Regulation of Biological Activity of Drugs

1992 • 161 citations

Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase

1995 • 159 citations

Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

1994 • 155 citations

Morphine metabolism in children.

1989 • 147 citations

The Maturation of Morphine Clearance and Metabolism

1992 • 146 citations

Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

1994 • 140 citations

Morphine glucuronidation in human fetal and adult liver

1982 • 140 citations

Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases

1993 • 137 citations

Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias

1997 • 132 citations

Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver

1979 • 131 citations

Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.

1993 • 129 citations

Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

1979 • 125 citations

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.

1989 • 115 citations

Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol.

1993 • 114 citations

Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus

1993 • 114 citations

Pharmacokinetics of Propofol after a Single Dose in Children Aged 1–3 Years with Minor Burns

1996 • 114 citations

Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms

1993 • 109 citations

New developments in glucuronidation research: Report of a workshop on “Glucuronidation, its role in health and disease”

1992 • 99 citations

Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives

1992 • 99 citations

Development of multiple activities of UDP-glucuronyltransferase in human liver

1987 • 98 citations

Ethnic differences in response to morphine

1993 • 98 citations

The enantioselective glucuronidation of morphine in rats and humans

1989 • 93 citations

Development of Human Liver UDP-Glucuronosyltransferases

1989 • 90 citations

Age-related differences in salicylamide and acetaminophen conjugation in man

1977 • 88 citations

Glucuronide Formation in Patients with Constitutional Hepatic Dysfunction (Gilbert's Disease)

1959 • 88 citations

Identification of an A-to-G Missense Mutation in Exon 2 of the UGT1 Gene Complex That Causes Crigler-Najjar Syndrome Type 2

1993 • 86 citations

Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.

1997 • 86 citations

Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4.

1993 • 85 citations

Kinetics of Salicylate Elimination by Newborn Infants of Mothers Who Ingested Aspirin Before Delivery

1974 • 84 citations

A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient

1996 • 84 citations

Chromosomal Localization, Structure, and Regulation of theUGT2B17Gene, Encoding a C19 Steroid Metabolizing Enzyme

1997 • 81 citations

Expression of a human liver cDNA encoding a UDP‐glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture

1989 • 80 citations

The UGT1A1*28 allele is relatively rare in a Japanese population

1998 • 80 citations

Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans

1995 • 71 citations

Genotype or phenotype: the definition of a pharmacogenetic polymorphism

1991 • 63 citations

Preclinical prediction of factors influencing the elimination of 5,6-dimethylxanthenone-4-acetic acid, a new anticancer drug.

1997 • 62 citations

Development of the Glucuronyltransferase and Sulphotransferase towards 2-Naphthol in Human Fetus

1990 • 62 citations

The Human UDP Glucuronosyltransferase, UGT1A10, Glucuronidates Mycophenolic Acid

1997 • 61 citations

Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro.

1994 • 60 citations

Isolation of a Human YAC Contig Encompassing a Cluster of UGT2 Genes and Its Regional Localization to Chromosome 4q13

1994 • 60 citations

Sulphation and glucuronidation of ritodrine in human foetal and adult tissues

1993 • 58 citations

Tissue-Specific 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Inducible Expression of Human UDP-Glucuronosyltransferase UGT1A6

1996 • 57 citations

Gilbert syndrome caused by a homozygousmissense mutation (Tyr486Asp) of bilirubinUDP-glucuronosyltransferase gene

1998 • 56 citations

Interindividual variability in the glucuronidation of (S) oxazepam contrasted with that of (R) oxazepam

1995 • 55 citations

Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation

1992 • 55 citations

Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome

1987 • 55 citations

Placental passage of oxazepam and its metabolism in mother and newborn

1979 • 55 citations

Fetal acquisition and neonatal elimination of a large amount of salicylate

1975 • 55 citations

Naloxone pharmacokinetics in the newborn.

1980 • 49 citations

Age-related differences in hepatic drug clearance in children: Studies with lorazepam and antipyrine

1991 • 48 citations

UGT1*1 genotyping in a Canadian Inuit population

1997 • 47 citations

Altered Coding for a Strictly Conserved Di-glycine in the Major Bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar Type I Patient

1995 • 43 citations

Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates

1988 • 34 citations

Characterisation of a human bilirubin UDP‐glucuronosyltransferase stably expressed in hamster lung fibroblast cell cultures

1992 • 33 citations

Evaluation of Pharmacokinetics, Safety, Tolerance, and Activity of Combination of Zalcitabine and Zidovudine in Stable, Zidovudine‐Treated Pediatric Patients with Human Immunodeficiency Virus Infection

1997 • 31 citations

In vitro glucuronidation of 3'-azido-3'-deoxythymidine by human liver. Role of UDP-glucuronosyltransferase 2 form.

1991 • 31 citations

Lorazepam Toxicity in a Premature Infant

1993 • 25 citations

Differential localisation of UDP-glucuronosyltransferase in kidney during human embryonic and fetal development

1995 • 23 citations

The ontogeny of key endoplasmic reticulum proteins in human embryonic and fetal red blood cells

1996 • 21 citations

Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?

1991 • 19 citations

Dextromethorphan O-demethylation and dextrorphan glucuronidation in a French population.

1993 • 17 citations

A study of conjugation and drug elimination in the human neonate.

1981 • 13 citations

Lack of a genetic polymorphism in the glucuronidation of fenofibric acid

1995 • 9 citations

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