Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

1999 • 2,458 citations

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 • 995 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

1997 • 378 citations

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 • 281 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: Screening costs and influence on clinical outcomes in psychiatry*

1996 • 156 citations

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.

1990 • 144 citations

Genetic Variation as a Guide to Drug Development

1998 • 143 citations

Genetically variable metabolism of antidepressants and neuroleptic drugs in man

1993 • 136 citations

The debrisoquine hydroxylation test predicts steady‐state plasma levels of desipramine.

1983 • 93 citations

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1988 • 87 citations

Rapid detection of CYP2D6 null alleles by long distance-and multiplex-polymerase chain reaction

1996 • 86 citations

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the human cytochrome P450 CYP2D6 gene

1995 • 73 citations

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

1998 • 63 citations

Impact of P450 genetic polymorphism on the first-pass extraction of cardiovascular and neuroactive drugs

1997 • 54 citations

Polymorphism of dextromethorphan metabolism: relationships between phenotype, genotype and response to the administration of encainide in humans.

1992 • 41 citations

Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report

1993 • 39 citations

Relationship of CYP2D6 (debrisoquine hydroxylase) genotype to breast cancer susceptibility

1993 • 26 citations

Prediction of phenotype for dextromethorphan O-demethylation by using polymerase chain reaction in healthy volunteers.

1995 • 9 citations