Polymorphisms in genes involved in neurotransmission in relation to smoking

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

Allelic Variation of Human Serotonin Transporter Gene Expression

1996 • 2,225 citations

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 • 1,620 citations

Some observations upon a new inhibitor of monoamine oxidase in brain tissue

1968 • 1,589 citations

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

1996 • 1,498 citations

Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

1996 • 1,207 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Neurobiology of addiction

1996 • 1,082 citations

A functional polymorphism in the monoamine oxidase A gene promoter

1998 • 1,070 citations

Multiple dopamine D4 receptor variants in the human population

1992 • 967 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants

1995 • 859 citations

Addictive Drugs and Brain Stimulation Reward

1996 • 777 citations

Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers

1999 • 728 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers

1998 • 679 citations

A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.

1996 • 667 citations

Inhibition of monoamine oxidase B in the brains of smokers

1996 • 666 citations

Organization of the human serotonin transporter gene

1994 • 623 citations

Some puzzling pharmacological effects of monoamine oxidase inhibitors.

1972 • 561 citations

D2 dopamine receptor gene (DRD2) Taql A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele

1997 • 551 citations

Polymorphism in serotonin transporter gene associated with susceptibility to major depression

1996 • 534 citations

Nicotine-Induced Limbic Cortical Activation in the Human Brain: A Functional MRI Study

1998 • 483 citations

A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia

1997 • 454 citations

Brain monoamine oxidase A inhibition in cigarette smokers

1996 • 427 citations

Role of human cytochrome P4502A6 in C-oxidation of nicotine.

1996 • 413 citations

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1990 • 387 citations

Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism

1994 • 378 citations

Genetic Influence on Smoking — A Study of Male Twins

1992 • 339 citations

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder

1997 • 311 citations

A Tryptophan Hydroxylase Gene Marker for Suicidality and Alcoholism

1998 • 305 citations

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

1995 • 293 citations

D2 and D4 dopamine receptor polymorphisms and personality

1998 • 289 citations

Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene

1999 • 283 citations

Evidence suggesting the role of specific genetic factors in cigarette smoking.

1999 • 282 citations

Influences of sensation seeking, gender, risk appraisal, and situational motivation on smoking

1990 • 276 citations

The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking

1996 • 267 citations

Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH)

1991 • 266 citations

Nicotine self-administration in animals and humans: similarities and differences

1997 • 262 citations

Human monoamine oxidase A gene determines levels of enzyme activity.

1991 • 259 citations

Genetic and environmental contributions to smoking

1997 • 251 citations

Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders

1992 • 241 citations

Case-Control Study of the D2 Dopamine Receptor Gene and Smoking Status in Lung Cancer Patients

1998 • 241 citations

Evidence suggesting the role of specific genetic factors in cigarette smoking.

1999 • 240 citations

Proposed Schizophrenia-Related Gene Polymorphism: Expression of the Ser9Gly Mutant Human Dopamine D3Receptor with the Semliki Forest Virus System

1996 • 233 citations

Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors

1997 • 227 citations

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

1997 • 222 citations

Effects of systemic nicotine on serotonin release in rat brain

1993 • 221 citations

D2 dopamine receptor gene and cigarette smoking: A reward gene?

1994 • 214 citations

Investigation of mechanisms linking depressed mood to nicotine dependence

1996 • 211 citations

A genetic association for cigarette smoking behavior.

1999 • 203 citations

Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT)

2000 • 198 citations

Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism

1999 • 196 citations

High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers

1997 • 181 citations

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism

1999 • 179 citations

Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait

2000 • 171 citations

Immunocytochemical localization of monoamine oxidases A and B in human peripheral tissues and brain.

1987 • 170 citations

Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.

1998 • 168 citations

Personality and the inheritance of smoking behavior: A genetic perspective

1995 • 167 citations

Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7

1997 • 166 citations

High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers

2000 • 165 citations

Association of a monoamine oxidase B allele with Parkinson's disease

1993 • 163 citations

5-HT2C (HTR2C)serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: Interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms

1997 • 162 citations

Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.

1998 • 161 citations

No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance

1997 • 160 citations

Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study

1999 • 159 citations

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C‐oxidase

1998 • 151 citations

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression

1998 • 149 citations

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

1996 • 149 citations

Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians.

1998 • 148 citations

Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence

2000 • 143 citations

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders

1995 • 142 citations

A Structural Polymorphism of Human Dopamine D2 Receptor D2(Ser311 → Cys)

1993 • 140 citations

Monoamine oxidase A and B activities in heavy smokers

1995 • 140 citations

Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior

2000 • 137 citations

Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations

2000 • 136 citations

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

1998 • 136 citations

Cloning, expression and structure of catechol-O-methyltransferase

1995 • 130 citations

Cloning and characterisation of the human 5‐HT_5A serotonin receptor

1994 • 129 citations

Relationship between serotonin and the Temperament and Character Inventory

1999 • 126 citations

Functional Analysis of the Human D2 Dopamine Receptor Missense Variants

1996 • 125 citations

Molecular basis of human MAO A and B.

1991 • 120 citations

Irreversible inhibition of monoamine oxidase by some components of cigarette smoke

1987 • 120 citations

Neuropharmacological Actions of Cigarette Smoke

1998 • 120 citations

Effects of nicotine and mecamylamine on rat dorsal raphe neurons

1998 • 118 citations

Relationship of tridimensional personality questionnaire scores and smoking variables in female and male smokers

1992 • 116 citations

Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese

1999 • 115 citations

Nicotine increases expression of tyrosine hydroxylase gene. Involvement of protein kinase A-mediated pathway.

1993 • 115 citations

Association between serotonin transporter gene polymorphism and smoking among Japanese males.

1999 • 115 citations

A Naturally Occurring Amino Acid Substitution of the Human Serotonin 5‐HT_2A Receptor Influences Amplitude and Timing of Intracellular Calcium Mobilization

1997 • 113 citations

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3 -pyridyl)thiazolidin-4-one hydrochloride (SM-12502)

1998 • 111 citations

Association of smoking and personality with a polymorphism of the dopamine transporter gene: Results from a community survey

2000 • 109 citations

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

1997 • 109 citations

Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1)

2000 • 107 citations

Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking

2000 • 106 citations

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene

1997 • 105 citations

A genome‐wide search for loci contributing to smoking and alcoholism

1999 • 101 citations

The role of the serotonin transporter gene in cigarette smoking.

1998 • 99 citations

Antidepressant pharmacotherapy helps some cigarette smokers more than others.

1999 • 98 citations

A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

1998 • 96 citations

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

1995 • 94 citations

Dopamine-related genes and their relationships to monoamine metabolites in CSF

1996 • 93 citations

Harm avoidance and serotonin

1999 • 92 citations

No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive–compulsive disorder, anorexia nervosa, and alcoholism

1999 • 89 citations

European multicentre association study of schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms

1998 • 89 citations

Role of MAO A and B in neurotransmitter metabolism and behavior.

1999 • 84 citations

No Association between Parkinson's Disease and Low-Activity Alleles of CatecholO-Methyltransferase

1996 • 84 citations

Suicidal Behaviors and the Tryptophan Hydroxylase Gene

1995 • 83 citations

Antidepressant pharmacotherapy helps some cigarette smokers more than others.

1999 • 83 citations

Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease

1999 • 82 citations

Identification of Tryptophan 2,3‐Dioxygenase RNA in Rodent Brain

1993 • 79 citations

MAO-A and -B gene knock-out mice exhibit distinctly different behavior.

1999 • 77 citations

Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q

1999 • 76 citations

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder

1997 • 74 citations

Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

1994 • 70 citations

Analysis of neuroleptic binding affinities and potencies for the different human D2 dopamine receptor missense variants

1999 • 67 citations

Smoking, nicotine and psychiatric disorders: evidence for therapeutic role, controversies and implications for future research

1999 • 66 citations

Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence

1999 • 64 citations

Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by tobacco smoke

1990 • 58 citations

HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses

1999 • 57 citations

Assessing the generalizability of smoking studies

1997 • 56 citations

The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease

1995 • 56 citations

The addictive role of nicotine in tobacco use

1995 • 55 citations

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism

1999 • 54 citations

Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders

1996 • 53 citations

Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene

1998 • 53 citations

Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity

1989 • 52 citations

Nicotine dependence and its familial aggregation in Chinese

2000 • 51 citations

An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study.

1998 • 50 citations

Functional analysis of the human D5 dopamine receptor missense and nonsense variants: differences in dopamine binding affinities.

1999 • 50 citations

Evidence for genetic influences on smoking in adult women twins

1995 • 49 citations

Effects of tobacco smoke constituents on MPTP-induced toxicity and monoamine oxidase activity in the mouse brain

1991 • 49 citations

Low CSF Concentration of a Dopamine Metabolite in Tobacco Smokers

1999 • 48 citations

Mutation and association analysis of the 5′ region of the dopamine D3 receptor gene in schizophrenia patients: identification of the Ala38Thr polymorphism and suggested association between DRD3 haplotypes and schizophrenia

2000 • 46 citations

Screening the dopamine D₁ receptor gene in 131 schizophrenics and eight alcoholics: Identification of polymorphisms but lack of functionally significant sequence changes

1995 • 44 citations

Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.

1998 • 40 citations

Brain event‐related potentials, dopamine D2 receptor gene polymorphism, and smoking

1999 • 39 citations

Frequent sequence variant in the human tyrosine hydroxylase gene

1995 • 38 citations

Lack of association of tyrosine hydroxylase genetic polymorphism with cigarette smoking

1997 • 38 citations

Identification and analysis of new sequence variants in the human tryptophan hydroxylase (TpH) gene

2000 • 38 citations

Point mutations within 663–666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY‐1 transcription factor binding site

1999 • 36 citations

Effects of Cigarette Smoking on Performance in a Simulated Driving Task

1995 • 36 citations

Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls

1994 • 35 citations

No association between Parkinson's disease and monoamine oxidase A and B gene polymorphisms

1996 • 34 citations

[Depression and smoking].

1996 • 34 citations

Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism

1998 • 32 citations

The monoamine oxidase B gene GT repeat polymorphism and Parkinson's disease in a Chinese population

2000 • 30 citations

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1999 • 30 citations

Mutational analysis of the humanMAOA gene

1996 • 29 citations

Dopaminergic Genes and Substance Abuse

1997 • 26 citations

The 5′ region of the tryptophan hydroxylase gene: mutation search and association study with alcoholism

1999 • 26 citations

Association Study Between Genetic Polymorphisms in the 14–3‐3 η Chain and Dopamine D4 Receptor Genes and Alcoholism

2000 • 14 citations

The Eco RV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease

2000 • 14 citations

Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene

1994 • 13 citations

Identification of a naturally occurring Pro15–Ser15 substitution in the serotonin5A receptor gene in alcoholics and healthy volunteers

1998 • 11 citations

A study of linkage disequilibrium between polymorphic loci for monamine oxidases A and B in schizophrenia

1999 • 10 citations

Nicotine Dependence:

1992 • 5 citations