The organic anion transporter family: from physiology to ontogeny and the clinic

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

The Kidney: Physiology and Pathophysiology.

1985 • 665 citations

Drug excretion mediated by a new prototype of polyspecific transporter

1994 • 637 citations

Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter

1997 • 619 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

1999 • 486 citations

Mechanisms mediating renal secretion of organic anions and cations

1993 • 484 citations

Expression Cloning and Characterization of ROAT1

1997 • 428 citations

Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta

2000 • 405 citations

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

1999 • 362 citations

Cytotoxicity of Antiviral Nucleotides Adefovir and Cidofovir Is Induced by the Expression of Human Renal Organic Anion Transporter 1

2000 • 352 citations

The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1

1999 • 345 citations

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

1998 • 339 citations

Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.

1995 • 324 citations

Structure of renal organic anion and cation transporters

2000 • 296 citations

Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

1997 • 256 citations

Molecular cloning and characterization of a novel liver-specific transport protein

1994 • 216 citations

Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral Therapy<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1999 • 203 citations

Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency

1999 • 195 citations

Postnatal development of renal function: micropuncture and clearance studies in the dog

1971 • 190 citations

Immunohistochemical Localization of Multispecific Renal Organic Anion Transporter 1 in Rat Kidney

1999 • 172 citations

Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C

1999 • 171 citations

Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy

1996 • 170 citations

Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)

1999 • 167 citations

Expression cloning and characterization of a renal organic anion transporter from winter flounder

1997 • 163 citations

Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.

1999 • 154 citations

Mutations of OCTN2, an Organic Cation/Carnitine Transporter, Lead to Deficient Cellular Carnitine Uptake in Primary Carnitine Deficiency

1999 • 150 citations

Indirect coupling to Na+ of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles

1987 • 142 citations

Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.

2000 • 140 citations

RENAL EXTRACTION OF PARA-AMINOHIPPURATE IN INFANTS AND CHILDREN*

1963 • 132 citations

pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.

1980 • 116 citations

Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct

2000 • 111 citations

Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles

1988 • 108 citations

Cloning of a Human Renal p–Aminohippurate Transporter, hROAT1

1998 • 101 citations

Filtration fraction and extraction of PAH during neonatal period in the rat

1970 • 94 citations

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

1996 • 92 citations

Regulation of mOAT-mediated Organic Anion Transport by Okadaic Acid and Protein Kinase C in LLC-PK1 Cells

2000 • 92 citations

Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation

1998 • 91 citations

Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems

1993 • 86 citations

Mechanism of Organic Anion Transport across the Apical Membrane of Choroid Plexus

1999 • 80 citations

A Novel Putative Transporter Maps to the Osteosclerosis (oc) Mutation and Is Not Expressed in theocMutant Mouse

1999 • 80 citations

RENAL CLEARANCES OF SODIUM PENICILLIN G, PROCAINE PENICILLIN G, AND INULIN IN INFANTS AND CHILDREN

1949 • 79 citations

Heterologous Expression and Functional Characterization of a Mouse Renal Organic Anion Transporter in Mammalian Cells

1999 • 76 citations

The molecular biology of renal organic anion and organic cation transporters

1999 • 73 citations

Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems

1993 • 68 citations

Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney

2000 • 63 citations

Regulation by protein kinase C of organic anion transport driven by rat organic anion transporter 3 (rOAT3)

2000 • 63 citations

Fluorescence imaging study of organic anion transport from renal proximal tubule cell to lumen

1996 • 60 citations

Maturation of renal organic acid transport: substrate stimulation by penicillin and p-aminohippurate (PAH).

1970 • 60 citations

Urate and p-aminohippurate transport in the brush border membrane of the pig kidney.

1990 • 56 citations

Transport of urate and p-aminohippurate in rabbit renal brush-border membranes

1990 • 53 citations

Development of renal tubular transports of TEA and PAH in the puppy and piglet

1961 • 53 citations

Development of mechanisms for drug excretion

1977 • 53 citations

Maturation of Renal Organic Acid Transport: Substrate Stimulation by Penicillin

1969 • 53 citations

Intracellular compartmentation of organic anions within renal cells

1993 • 51 citations

Stimulation of renal organic acid transport and protein synthesis by penicillin.

1970 • 40 citations

Localization of an organic anion transporter-GFP fusion construct (rROAT1-GFP) in intact proximal tubules

1999 • 39 citations

PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules

2000 • 38 citations

Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets

1996 • 37 citations

Luminal transport step of para -aminohippurate (PAH): transport from PAH-loaded proximal tubular cells into the tubular lumen of the rat kidney in vivo

1997 • 35 citations

In vitro analysis of organic ion transport in renal cortex of the newborn rat.

1972 • 33 citations

Nocodazole inhibition of organic anion secretion in teleost renal proximal tubules

1994 • 31 citations

Functional maturation of renal PAH transport in the dog

1970 • 31 citations

Binding of N1-methylnicotinamide and p-aminohippuric acid to a particulate fraction from dog kidney.

1975 • 30 citations

A single amino acid mutation (Ser180----Cys) determines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.

1992 • 28 citations

The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains

1997 • 27 citations

Hormonal control of postnatal development of renal tubular transport of weak organic acids

1988 • 22 citations

Transport ontogeny and selective substrate stimulation as models for identification of multiple renal organic anion transport systems.

1977 • 21 citations

Confocal microscopic analysis of fluorescein compartmentation within crab urinary bladder cells

1994 • 21 citations

Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages

1978 • 13 citations

PAH Clearance, Sodium Excretion, and PAH Extraction Ratio in Acidotic Near-Term Lambs Treated with Hypertonic Sodium Bicarbonate

1976 • 9 citations

Stimulation of p-aminohippurate Transport by Slices of Rat Renal Cortex Following in Vivo Administration of Triiodothyronine

1969 • 9 citations

Stimulation of renal p-aminohippurate transport by folic acid

1969 • 7 citations