Modelling of the blood‐brain barrier transport of morphine‐3‐glucuronide studied using microdialysis in the rat: involvement of probenecid‐sensitive transport

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.

1981 • 781 citations

The multidrug resistance protein family

1999 • 654 citations

TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER¹

1977 • 525 citations

Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

1990 • 501 citations

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1999 • 444 citations

Drainage of interstitial fluid from different regions of rat brain

1984 • 348 citations

The Concept of a Blood-Brain Barrier

1980 • 347 citations

Efflux of radiolabeled polyethylene glycols and albumin from rat brain

1981 • 311 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity

1991 • 211 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

1999 • 198 citations

Demonstration of a Coupled Metabolism–Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics

1999 • 180 citations

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method.

1997 • 176 citations

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

1999 • 162 citations

Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method.

1998 • 129 citations

Species difference of site-selective glucuronidation of morphine.

1991 • 128 citations

The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach.

1996 • 127 citations

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.

1996 • 122 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2

1998 • 121 citations

Extracellular space of rat cerebral cortex

1967 • 110 citations

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1993 • 104 citations

BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.

1998 • 103 citations

Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.

1998 • 94 citations

Testing Computer-controlled Infusion Pumps by Simulation

1988 • 93 citations

Octanol−, Chloroform−, and Propylene Glycol Dipelargonat−Water Partitioning of Morphine-6-glucuronide and Other Related Opiates

1996 • 89 citations

Study on brain interstitial fluid distribution and blood-brain barrier transport of baclofen in rats by microdialysis.

1995 • 80 citations

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

1999 • 76 citations

Pharmacokinetics and pharmacodynamics of morphine‐3‐glucuronide in rats and its influence on the antinociceptive effect of morphine

1993 • 74 citations

Biochemical and clinical aspects of efflux pump related resistance to anti-cancer drugs.

1998 • 54 citations

Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system.

1994 • 53 citations

Comparison of calibration by delivery versus no net flux for quantitative in vivo microdialysis sampling

1999 • 48 citations

High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).

1999 • 44 citations

A Preliminary Study on the Distribution of Morphine and Its Glucuronides in the Subcompartments of Blood

1998 • 44 citations

Quinolinic Acid Is Extruded from the Brain by a Probenecid‐Sensitive Carrier System: A Quantitative Analysis

1999 • 38 citations

Morphine-3-Glucuronide Has a Minor Effect on Morphine Antinociception. Pharmacodynamic Modeling

1998 • 38 citations

Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression.

1994 • 33 citations

Rationale for influx enhancement versus efflux blockade to increase drug exposure to the brain

1998 • 19 citations

Plasma and Cerebrospinal Fluid Concentrations of Morphine and Morphine Glucuronides in Rabbits Receiving Single and Repeated Doses of Morphine

1995 • 15 citations

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