Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

1996 • 373 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population*

1995 • 187 citations

Codeine O‐demethylation co‐segregates with polymorphic debrisoquine hydroxylation.

1989 • 139 citations