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Mechanisms of Reperfusion Injury

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Methylarsenicals and Arsinothiols Are Potent Inhibitors of Mouse Liver Thioredoxin Reductase

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Targeted Deletion of the Cytosolic Cu/Zn-Superoxide Dismutase Gene (<i>Sod1</i>) Increases Susceptibility to Noise-Induced Hearing Loss

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The participation of coenzyme Q in free radical production and antioxidation

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Elevation of plasma thioredoxin levels in HIV-infected individuals

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Is ascorbic acid an antioxidant for the plasma membrane?

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Current Protocols in Toxicology

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Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

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Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase

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Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase

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1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase

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Structural and Functional Changes in Proteins Induced by Free Radical‐mediated Oxidative Stress and Protective Action of the Antioxidants N‐tert‐Butyl‐α‐phenylnitrone and Vitamin E^a

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Nitric Oxide Reaction with Lipid Peroxyl Radicals Spares α-Tocopherol during Lipid Peroxidation

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Mitochondria in organismal aging and degeneration

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Repression of gene expression by oxidative stress

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Mouse Peroxiredoxin V Is a Thioredoxin Peroxidase That Inhibits p53-Induced Apoptosis

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Thioredoxin as a potent costimulus of cytokine expression.

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Thioredoxin and related proteins in procaryotes

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The Mitochondrial Thioredoxin System

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Characterization of Sptrx, a Novel Member of the Thioredoxin Family Specifically Expressed in Human Spermatozoa

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Human Keratinocytes Constitutively Express Interleukin-18 and Secrete Biologically Active Interleukin-18 After Treatment with Pro-Inflammatory Mediators and Dinitrochlorobenzene

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Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

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Selenium and the thioredoxin and glutaredoxin systems.

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Effect of oxidative DNA damage in promoter elements on transcription factor binding

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Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS

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α-Lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium

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Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo

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A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene

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Expression and growth-promoting effect of adult t-cell leukemia-derived factor a human thioredoxin homologue in hepatocellular carcinoma

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Elevation of Manganese Superoxide Dismutase Gene Expression by Thioredoxin

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The protein disulphide-isomerase family: unravelling a string of folds

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The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): Thioredoxin mRNA is elevated in some human tumors

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Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability

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Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity

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Oxidized LDL and Atherogenesis^a

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Measurement of Thioredoxin and Thioredoxin Reductase

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Human Neutrophil Antimicrobial Activity

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Cytosolic and Mitochondrial Systems for NADH- and NADPH-dependent Reduction of α-Lipoic Acid

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NK-lysin, a Disulfide-containing Effector Peptide of T-lymphocytes, Is Reduced and Inactivated by Human Thioredoxin Reductase

1996 • 127 citations

Reaction of the Desulfoferrodoxin from Desulfoarculus baarsii with Superoxide Anion

2000 • 125 citations

Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II)

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Involvement of Thioredoxin in Rheumatoid Arthritis: Its Costimulatory Roles in the TNF-α-Induced Production of IL-6 and IL-8 from Cultured Synovial Fibroblasts

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Ascorbate function and metabolism in the human erythrocyte

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Knowing when not to stop: selenocysteine incorporation in eukaryotes

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The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase

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Role of thioredoxin reductase in the Yap1p‐dependent response to oxidative stress in Saccharomyces cerevisiae

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Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells

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Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma

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Modulation of the activity of human monocyte-derived dendritic cells by chemical haptens, a metal allergen, and a staphylococcal superantigen

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Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector. Explanation for variations in paraquat resistance.

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Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family.

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A CD4⁺ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin

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ADF, A Growth-Promoting Factor Derived from Adult T Cell Leukemia and Homologous to Thioredoxin: Involvement in Lymphocyte Immortalization by HTLV-I and EBV

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Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion.

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Heterogeneity within Animal Thioredoxin Reductases

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Superoxide: a two-edged sword

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Glutathione Reductase and Lipoamide Dehydrogenase Have Opposite Stereospecificities for α-Lipoic Acid Enantiomers

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Enzyme-Dependent Ascorbate Recycling in Human Erythrocytes: Role of Thioredoxin Reductase

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Simple chemicals can induce maturation and apoptosis of dendritic cells

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The Core Promoter of Human Thioredoxin Reductase 1

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High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells.

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The NADPH‐Dependent Oxidase of Phagocytes

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Amyotrophic lateral sclerosis: copper/zinc superoxide dismutase (SOD1) gene mutations

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Dissecting G Protein-coupled Receptor Signaling Pathways with Membrane-permeable Blocking Peptides

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Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase.

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Classification of Chemical Allergens According to Cytokine Secretion Profiles of Murine Lymph Node Cells

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Induction of thioredoxin and thioredoxin reductase gene expression in lungs of newborn primates by oxygen

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Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.

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Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage

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Thioredoxin Reductase Mediates Cell Death Effects of the Combination of Beta Interferon and Retinoic Acid

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Two resident ER‐proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase

1995 • 81 citations

Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases

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Mitochondrial thioredoxin reductase in bovine adrenal cortex

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Thioredoxin increases the proliferation of human B-cell lines through a protein kinase C-dependent mechanism.

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Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes

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Expression of Selenoproteins in Various Rat and Human Tissues and Cell Lines

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Implications of Inducible Nitric Oxide Synthase Expression and Enzyme Activity

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Dinitrochlorobenzene Therapy for Alopecia Areata

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The Chemistry and Function of Lipoic Acid

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Cellular thioredoxin reductase activity is regulated by selenium.

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The Caenorhabditis elegans Homologue of Thioredoxin Reductase Contains a Selenocysteine Insertion Sequence (SECIS) Element That Differs from Mammalian SECIS Elements but Directs Selenocysteine Incorporation

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AhpF Can Be Dissected into Two Functional Units: Tandem Repeats of Two Thioredoxin-like Folds in the N-Terminus Mediate Electron Transfer from the Thioredoxin Reductase-like C-Terminus to AhpC

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Reduction of ubiquinone by lipoamide dehydrogenase

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Reduction and transport of lipoic acid by human erythrocytes

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Oxidative stress induces adult T cell leukemia derived factor/thioredoxin in the rat retina.

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Aurothioglucose Inhibits Murine Thioredoxin Reductase Activity In Vivo

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Protection Against Reperfusion-Induced Arrhythmias by Human Thioredoxin

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CD40 function in nonhematopoietic cells. Nuclear factor kappa B mobilization and induction of IL-6 production.

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Diminished Contact Sensitivity Response in Vitiliginous Skin

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Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.

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Delayed-type hypersensitivity skin testing. A review.

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Enhanced expression of IL‐8 in normal human keratinocytes and human keratinocyte cell line HaCaT in vitro after stimulation with contact sensitizers., tolerogens and irritants

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Loss of DNA-membrane interactions and cessation of DNA synthesis in myeloperoxidase-treated Escherichia coli.

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GRP78, HSP72/73, and cJun Stress Protein Levels in Lung Epithelial Cells Exposed to Asbestos, Cadmium, or H 2 O 2

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Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin. Relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity.

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Possible functional impairment of Langerhans' cells in vitiliginous skin. Reduced ability to elicit dinitrochlorobenzene contact sensitivity reaction and decreased stimulatory effect in the allogeneic mixed skin cell lymphocyte culture reaction

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Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus.

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Evidence for a functional relevance of the selenocysteine residue in mammalian thioredoxin reductase

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Secretion of 10-kDa and 12-kDa Thioredoxin Species from Blood Monocytes and Transformed Leukocytes

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The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid

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Treatment of the Common Wart by Induced Allergic Inflammation

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Human eosinophil cytotoxicity-enhancing factor. II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin/adult T cell leukemia-derived factor.

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A Research Trail Over Half a Century

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Superoxide Reductase as a Unique Defense System against Superoxide Stress in the Microaerophile Treponema pallidum

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Thioredoxin overexpression prevents NO-induced reduction of NO synthase activity in lung endothelial cells

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Iron release from ferritin and its sensitivity to superoxide ions differs among vertebrates

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cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene

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Mechanism of Production of Toxic Oxygen Radicals by Granulocytes and Macrophages and their Function in the Inflammatory Process

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Regulation of Interferon and Retinoic Acid-induced Cell Death Activation through Thioredoxin Reductase

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HPLC-methods for determination of lipoic acid and its reduced form in human plasma.

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Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region

2000 • 38 citations

The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme.

1995 • 38 citations

Interaction of α-Lipoic acid enantiomers and homologues with the enzyme components of the mammalian pyruvate dehydrogenase complex

1995 • 34 citations

Vitamin C recycling and function in human monocytic U-937 cells

1999 • 33 citations

Cytokine Production by CD4+ and CD8+ T Cells in Mice following Primary Exposure to Chemical Allergens: Evidence for Functional Differentiation of T Lymphocytes in vivo

1998 • 33 citations

Pilot study of topical dinitrochlorobenzene (DNCB) in human immunodeficiency virus infection

1993 • 33 citations

Antioxidants and lipoprotein metabolism

1999 • 32 citations

Signals involved in the early TH1 /TH2 polarization of an immune response depending on the type of antigen

1999 • 31 citations

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

1996 • 31 citations

Nitric Oxide and Low-Density Lipoprotein Oxidation

1998 • 30 citations

Differential induction of cutaneous TNF-$alpha; and IL-6 by topically applied chemicals

1997 • 29 citations

Superoxide production by dinitrophenyl‐ derivatized thioredoxin reductase ‐ a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes

1999 • 29 citations

Lens-Specific Regulation of the Thioredoxin-1 Gene, but Not Thioredoxin-2, upon in Vivo Photochemical Oxidative Stress in the Emory Mouse

1999 • 29 citations

Kinetic study of the reaction of vitamin C with vitamin E radicals (tocopheroxyls) in solution

1989 • 27 citations

Clinical and immunologic evaluation of HIV-infected patients treated with dinitrochlorobenzene

1994 • 27 citations

The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells

1995 • 26 citations

News and views on thioredoxin reductases

1999 • 24 citations

Biochemical responses of skin to allergenic and non-allergenic nitrohalobenzenes

1992 • 24 citations

TOPICAL IMMUNOTHERAPY IN DERMATOLOGY

1999 • 22 citations

Dendritic cells and dinitrochlorobenzene (DNCB): a new treatment approach to AIDS

1991 • 21 citations

Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin

1992 • 21 citations

Inhibition Of Thioredoxin Reductase (E.C. 1.6.4.5.) By Antitumor Quinones

1990 • 20 citations

Induction of Interleukin-12/p40 by Superantigens in Macrophages Is Mediated by Activation of Nuclear Factor-κB

2000 • 20 citations

The mechanisms and evaluation of chemically induced allergy

1992 • 18 citations

Dinitrochlorobenzene therapy for alopecia areata

1978 • 18 citations

Topical Immune Modulation with Dinitrochlorobenzene in HIV Disease: A Controlled Trial from Brazil

1997 • 17 citations

Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussis toxin-sensitive signaling mechanisms

2000 • 16 citations

Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region

2000 • 14 citations

Analysis of interleukin 12 protein production and mRNA expression in mice exposed topically to chemical allergens

1999 • 13 citations

Delayed-type hypersensitivity skin testing. A review

1983 • 13 citations

Diminished contact sensitivity response in vitiliginous skin

1984 • 7 citations

Epidermal Cytokine mRNA Expression Induced by Hapten Differs from that Induced by Primary Irritant in Human Skin Organ Culture System

1998 • 5 citations

Deleted Work

1955 • 0 citations