Involvement of thioredoxin in rheumatoid arthritis: its costimulatory roles in the TNF-alpha-induced production of IL-6 and IL-8 from cultured synovial fibroblasts.

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis

1995 • 917 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells

1995 • 540 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Activation of the transcription factor nuclear factor‐κB in human inflamed synovial tissue

1996 • 314 citations

HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT

1989 • 290 citations

Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65

1995 • 289 citations

Oxidants, inflammation, and anti‐inflammatory drugs

1988 • 267 citations

The synovial expression and serum levels of interleukin‐6, interleukin‐11, leukemia inhibitory factor, and oncostatin m in rheumatoid arthritis

1997 • 232 citations

Hypoxia, oxidative stress and rheumatoid arthritis

1995 • 229 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.

1991 • 204 citations

Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint. Detection of abnormal low-molecular-mass metabolites by proton-n.m.r. spectroscopy

1991 • 178 citations

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.

1997 • 170 citations

Thioredoxin as a potent costimulus of cytokine expression.

1996 • 166 citations

Role of cytokines, acute-phase proteins, and chemokinesin the progression of rheumatoid arthritis

1996 • 166 citations

Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

1988 • 156 citations

Inhibition of the DNA‐binding activity of NF‐κB by gold compounds in vitro

1995 • 155 citations

The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA)

1985 • 154 citations

A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene

1996 • 145 citations

Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism

1992 • 138 citations

Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium.

1993 • 131 citations

Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin

1996 • 121 citations

Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells

1995 • 115 citations

Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor.

1987 • 105 citations

Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins

1997 • 84 citations

Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells.

1995 • 78 citations

Regulation of NF-κB and Disease Control: Identification of a Novel Serine Kinase and Thioredoxin as Effectors for Signal Transduction Pathway for NF-κB Activation

1997 • 75 citations

Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose

1999 • 69 citations

Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis.

1995 • 63 citations

Interleukin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid.

1995 • 54 citations

Characterization of an integrase mutant of feline immunodeficiency virus

1998 • 48 citations

Profile of Cytokines in Synovial Fluid Specimens from Patients with Arthritis. Interleukin 8 (IL-8) and IL-6 Correlate with Inflammatory Arthritides

1992 • 41 citations

Alteration of the cellular response to interleukin-1ß by SV40 large T antigen in rheumatoid synovial fibroblasts

1999 • 12 citations