Antioxidant defence mechanisms: From the beginning to the end (of the beginning)

Superoxide Dismutase

1969 • 12,578 citations

Structure-antioxidant activity relationships of flavonoids and phenolic acids

1996 • 8,781 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

1992 • 3,313 citations

Fenton's reagent revisited

1975 • 2,778 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

Protection against oxygen radicals: an important defence mechanism studied in transgenic plants

1994 • 1,249 citations

Oxygen radicals and signaling

1998 • 1,163 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Oxygen Poisoning and X-irradiation: A Mechanism in Common

1954 • 917 citations

Glutathione and ascorbic acid in spinach (Spinacia oleracea) chloroplasts. The effect of hydrogen peroxide and of Paraquat

1983 • 844 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

The Utility of Superoxide Dismutase in Studying Free Radical Reactions

1969 • 550 citations

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

1996 • 528 citations

Human Placenta Thioredoxin Reductase

1998 • 519 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1988 • 429 citations

Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs.

1994 • 415 citations

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

1997 • 414 citations

Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?

1988 • 408 citations

Proceedings of the Nutrition Society

1985 • 408 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

Why Do We Expect Carotenoids to be Antioxidantsin vivo?

1997 • 362 citations

Role of nitric oxide in cardiovascular disease: focus on the endothelium

1998 • 342 citations

Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase

1998 • 328 citations

Ovarian Function in Superoxide Dismutase 1 and 2 Knockout Mice

1998 • 279 citations

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis.

1987 • 266 citations

Nitric Oxide Inhibition of Lipid Peroxidation: Kinetics of Reaction with Lipid Peroxyl Radicals and Comparison with α-Tocopherol

1997 • 252 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

The Effects of Iron and Vitamin C Co-supplementation on Oxidative Damage to DNA in Healthy Volunteers

1998 • 210 citations

Estimating Hydroxyl Radical Content in Rat Brain Using Systemic and Intraventricular Salicylate: Impact of Methamphetamine

1995 • 202 citations

Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects

1999 • 195 citations

No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers

1997 • 188 citations

Oxygen Toxicity: Comparison of Lung Biochemical Responses in Neonatal and Adult Rats

1978 • 182 citations

Reduction of oxidative DNA-damage in humans by Brussels sprouts

1995 • 174 citations

Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies

1998 • 171 citations

The respiratory burst oxidase

1995 • 161 citations

The Complex Chemistry of Peroxynitrite Decomposition: New Insights¹

1998 • 161 citations

Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates.

1998 • 154 citations

Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk

1995 • 145 citations

Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients

1992 • 139 citations

Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis

1994 • 137 citations

Pathology of Oxygen Toxicity

1983 • 136 citations

Pathology of oxygen toxicity

1982 • 136 citations

Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates

1998 • 133 citations

Role of Ferritin in the Control of the Labile Iron Pool in Murine Erythroleukemia Cells

1998 • 131 citations

Highlights of Current Research Involving Superoxide and Perhydroxyl Radicals in Aqueous Solutions

1991 • 129 citations

Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.

1997 • 124 citations

Free Radicals and Iron: Chemistry, Biology, and Medicine

1998 • 114 citations

Peroxynitrous Acid Homolyzes into ^•OH and ^•NO₂ Radicals

1998 • 111 citations

Commentary: The Role of Iron-Sulfur Clusters inin vivoHydroxyl Radical Production

1996 • 108 citations

Measurement of Radiation-induced Damage to DNA at the Molecular Level

1992 • 90 citations

Oxidative DNA Damage in Human Respiratory Tract Epithelial Cells. Time Course in Relation to DNA Strand Breakage

1996 • 86 citations

Peroxynitrite-Dependent Aromatic Hydroxylation and Nitration of Salicylate and Phenylalanine. Is Hydroxyl Radical Involved?

1997 • 84 citations

NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C

1993 • 83 citations

Hydroxylation of Salicylate and Phenylalanine as Assays for Hydroxyl Radicals: a Cautionary Note Visited for the Third Time

1997 • 79 citations

o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation

1989 • 74 citations

Chloroplast Metabolism:

1982 • 74 citations

NEWS

1996 • 73 citations

Light activation of fructose bisphosphatase in isolated spinach chloroplasts and deactivation by hydrogen peroxide

1981 • 73 citations

NEWS: Beta-carotene takes a collective beating

1996 • 53 citations

Hydroxyl radical generation by rheumatoid blood and knee joint synovial fluid.

1996 • 52 citations

Food-derived antioxidants. Evaluating their importance in food and in vivo

1999 • 46 citations

Commentary Salicylate Trapping of -OH as a Tool for Studying Post-Ischemic Oxidative Injury in the Isolated Rat Heart

1994 • 41 citations

Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice

1992 • 38 citations

Histological analysis of selected brain regions of hypotransferrinerrinemic mice

1994 • 37 citations

Selenoprotein P: recent studies in rats and in humans.

1997 • 35 citations

Do iron and vitamin C co-supplementation influence platelet function or LDL oxidizability in healthy volunteers?

1999 • 30 citations

Hyperoxia and salicylate metabolism in rats

1990 • 22 citations

Food science and agricultural chemistry

1999 • 12 citations

Application of Spin Trapping to Human Phagocytic Cells: Insight Into Conditions for Formation and Limitation of Hydroxyl Radical

1991 • 8 citations

Introduction

1998 • 6 citations