Signals involved in the early TH1 /TH2 polarization of an immune response depending on the type of antigen

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

High Frequency of IL-4–Producing CD4+ Allergen-Specific T Lymphocytes in Atopic Dermatitis Lesional Skin

1991 • 397 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones.

1989 • 304 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994 • 232 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Th1 Lymphokine Production Profiles of Nickel-Specific CD4+ T-Lymphocyte Clones from Nickel Contact Allergic and Non-Allergic Individuals

1992 • 189 citations

Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice.

1996 • 185 citations

IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo.

1995 • 139 citations

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

1997 • 132 citations

The Route of Antigen Entry Determines the Requirement for L-selectin during Immune Responses

1996 • 111 citations

Th1 and Th2 CD4+ Cells in the Pathogenesis of Allergic Diseases

1997 • 100 citations

Increased airways responsiveness in mice depends on local challenge with antigen.

1994 • 72 citations

IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.

1992 • 69 citations

Induction of Tyrosine Phosphorylation in Human MHC Class II-Positive Antigen-Presenting Cells by Stimulation with Contact Sensitizers

1998 • 61 citations

Contact Sensitivity as a Model for T-Cell Activation in Skin

1995 • 60 citations

Food allergens

1985 • 53 citations

Evidence for Th2-type T helper cell control of allergic disease in vivo

1993 • 39 citations

Epidermal Cells Enhance Interleukin 4 and Immunoglobulin E Production After Stimulation with Protein Allergen

1996 • 11 citations