Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity

Principles of protein structure

1980 • 1,094 citations

Principles of Protein Structure

1979 • 1,090 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Rat liver thioredoxin and thioredoxin reductase: purification and characterization

1982 • 610 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases

1995 • 328 citations

Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases

1999 • 327 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

1997 • 227 citations

Cloning and sequencing of a human thioredoxin reductase

1995 • 211 citations

Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.

1988 • 137 citations

Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements

1999 • 108 citations

Human thioredoxin reductase from HeLa cells: Selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

1998 • 100 citations

Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase

1989 • 82 citations

Selenols catalyze the interchange reactions of dithiols and disulfides in water

1991 • 76 citations

The Caenorhabditis elegans Homologue of Thioredoxin Reductase Contains a Selenocysteine Insertion Sequence (SECIS) Element That Differs from Mammalian SECIS Elements but Directs Selenocysteine Incorporation

1999 • 71 citations

Structure of a cis-peptide unit: molecular conformation of the cyclic disulphide <scp>L</scp>-cysteinyl-<scp>L</scp>-cysteine

1977 • 61 citations

Thioredoxin Reductase from Plasmodium falciparum: Evidence for Interaction between the C-Terminal Cysteine Residues and the Active Site Disulfide−Dithiol

1999 • 52 citations

Human Selenium-Dependent Thioredoxin Reductase from HeLa Cells: Properties of Forms with Differing Heparin Affinities

1999 • 17 citations