Glutathione conjugation as a bioactivation reaction

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

1999 • 1,494 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases

1997 • 1,136 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Functional antioxidant responsive elements

1997 • 702 citations

Concise review of the glutathione S-transferases and their significance to toxicology

1999 • 617 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1997 • 498 citations

Increased skin tumorigenesis in mice lacking pi class glutathione S -transferases

1998 • 379 citations

Glutathione S-transferase: genetics and role in toxicology

2000 • 375 citations

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

2000 • 317 citations

Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera

1997 • 231 citations

Glutathione conjugate mediated toxicities*1

1990 • 228 citations

Biotransformation of the Naturally Occurring Isothiocyanate Sulforaphane in the Rat: Identification of Phase I Metabolites and Glutathione Conjugates

1997 • 196 citations

Chemistry, Analysis, and Biological Roles ofS-Nitrosothiols

1997 • 181 citations

Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.

1994 • 161 citations

The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

1980 • 159 citations

Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse: Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human

1997 • 154 citations

Metabolism of trichloroethylene in man

1974 • 143 citations

Regioselectivity and Reversibility of the Glutathione Conjugation of Quercetin Quinone Methide

2000 • 134 citations

Polymorphisms at the glutathione S‐transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation

2000 • 127 citations

GLUTATHIONE-DEPENDENT BIOACTIVATION OF HALOALKENES

1998 • 123 citations

The Three-Dimensional Structure of the Human Pi Class Glutathione Transferase P1-1 in Complex with the Inhibitor Ethacrynic Acid and Its Glutathione Conjugate^,

1997 • 121 citations

Characterization of a Human GlutathioneS-Transferase μ Cluster Containing a DuplicatedGSTM1Gene that Causes Ultrarapid Enzyme Activity

1997 • 118 citations

Renal Toxicity and Carcinogenicity of Trichloroethylene: Key Results, Mechanisms, and Controversies

2000 • 116 citations

Glutathione and N-Acetylcysteine Conjugates of α-Methyldopamine Produce Serotonergic Neurotoxicity: Possible Role in Methylenedioxyamphetamine-Mediated Neurotoxicity

1999 • 111 citations

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among Northwestern Mediterraneans

1997 • 111 citations

Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate

1986 • 110 citations

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

1997 • 106 citations

S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane

1986 • 104 citations

GlutathioneS-transferase-mediated induction of GC → AT transitions by halomethanes in salmonella

1997 • 102 citations

THE PHARMACOLOGY AND TOXICOLOGY OF POLYPHENOLIC-GLUTATHIONE CONJUGATES

1998 • 99 citations

Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate β-Lyase Pathway

1994 • 96 citations

Peroxidase-catalyzed Oxidation of Eugenol: Formation of a Cytotoxic Metabolite(s)

1989 • 96 citations

p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates

1992 • 96 citations

Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate

2000 • 90 citations

Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases.

1992 • 89 citations

Stereoselective Conjugation of Prostaglandin A₂ and Prostaglandin J₂ with Glutathione, Catalyzed by the Human Glutathione S-Transferases A1-1, A2-2, M1a-1a, and P1-1

1997 • 88 citations

Increased bioactivation of dihaloalkanes in rat liver due to induction of class Theta glutathione S-transferase T1-1

1998 • 87 citations

Structure and Function of the Xenobiotic Substrate-Binding Site and Location of a Potential Non-Substrate-Binding Site in a Class π Glutathione S-Transferase^,

1997 • 83 citations

Glutathione Conjugation of Alkylating Cytostatic Drugs with a Nitrogen Mustard Group and the Role of Glutathione S-Transferases

1996 • 82 citations

Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.

1994 • 82 citations

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1997 • 82 citations

Inhibition of Glutathione S-Transferase ζ and Tyrosine Metabolism by Dichloroacetate: A Potential Unifying Mechanism for Its Altered Biotransformation and Toxicity

1999 • 74 citations

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

1996 • 73 citations

Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase

1998 • 69 citations

Intracellular S-Glutathionyl Adducts in Murine Lung and Human Bronchoepithelial Cells after Exposure to Diisocyanatotoluene

1999 • 68 citations

Members of the glutathione S-transferase gene family are antigens in autoimmune hepatitis

1998 • 65 citations

Inactivation of Glutathione Transferase Zeta by Dichloroacetic Acid and Other Fluorine-Lacking α-Haloalkanoic Acids

1999 • 64 citations

Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney

1998 • 61 citations

The inhibition of glutathione S-transferases: Mechanisms, toxic consequences and therapeutic benefits

1991 • 59 citations

Cellular Response to a GlutathioneS-Transferase P1-1 Activated Prodrug

2000 • 53 citations

Comparison of human liver and small intestinal glutathione S-transferase-catalyzed busulfan conjugation in vitro.

1998 • 48 citations

Interindividual differences in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase in 22 human liver samples

1993 • 46 citations

The Use of Humanin VitroMetabolic Parameters to Explore the Risk Assessment of Hazardous Compounds: The Case of Ethylene Dibromide

1997 • 46 citations

Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein

1988 • 45 citations

Glutathione S-Transferase in Mucus of Rat Small Intestine

2000 • 44 citations

Dichloromethane Metabolism to Formaldehyde and Reaction of Formaldehyde with Nucleic Acids in Hepatocytes of Rodents and Humans with and without Glutathione S-Transferase T1 and M1 Genes

1997 • 38 citations

The Putative Benzene Metabolite 2,3,5-Tris(glutathion-S-yl)hydroquinone Depletes Glutathione, Stimulates Sphingomyelin Turnover, and Induces Apoptosis in HL-60 Cells

2000 • 35 citations

Reversibility in Glutathione-Conjugate Formation

1994 • 33 citations

Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells.

1998 • 32 citations

Dichloromethane Metabolism to Formaldehyde and Reaction of Formaldehyde with Nucleic Acids in Hepatocytes of Rodents and Humans with and without GlutathioneS-TransferaseT1andM1Genes

1997 • 32 citations

Identification of the Nonsubstrate Steroid Binding Site of Rat Liver GlutathioneS-Transferase, Isozyme 1-1, by the Steroid Affinity Label, 3β-(Iodoacetoxy)dehydroisoandrosterone

1997 • 29 citations

Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system

1999 • 29 citations

Active-site tyrosyl residues are targets in the irreversible inhibition of a class Mu glutathione transferase by 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone.

1994 • 27 citations

DNA–Protein Cross-Links (DPX) and Cell Proliferation in B6C3F1Mice but Not Syrian Golden Hamsters Exposed to Dichloromethane: Pharmacokinetics and Risk Assessment with DPX as Dosimeter

1996 • 27 citations

Thioltransferase activity of bovine lens glutathione S-transferase

1998 • 26 citations

Stereoselective Catalysis of a Retro-Michael Reaction by Class Mu Glutathione Transferases. Consequences for the Internal Distribution of Products in the Active Site

1995 • 26 citations

Human testicular glutathione S-transferases: insights into tissue-specific expression of the diverse subunit classes

1998 • 26 citations

Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man

1999 • 25 citations

DNA—Protein Cross-Links (DPX) and Cell Proliferation in B6C3F₁ Mice but Not Syrian Golden Hamsters Exposed to Dichloromethane: Pharmacokinetics and Risk Assessment with DPX as Dosimeter

1996 • 23 citations

Methyl linoleate ozonide as a substrate for rat glutathione S-transferases: Reaction pathway and isoenzyme selectivity

1989 • 21 citations

Identification of S-(n-Butylcarbamoyl)glutathione, a Reactive Carbamoylating Metabolite of Tolbutamide in the Rat, and Evaluation of Its Inhibitory Effects on Glutathione Reductase in Vitro

1999 • 20 citations

Retinoids inhibit mammalian glutathione transferases

1995 • 18 citations

GSTP1‐1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid

1998 • 16 citations

Identification of thetrans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes and in liver as GST1

1989 • 16 citations

Identification of the fatty acid binding site on glutathione S-transferase P

1992 • 16 citations

Inhibition of human glutathione S-transferases by dopamine, α-methyldopa and their 5-S-glutathionyl conjugates

1994 • 15 citations

Haloenol Lactone: A New Synergist of Chemotherapyin Vitro

1997 • 11 citations

Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats

1996 • 10 citations

Affinity Labeling of Pig Lung GlutathioneS-Transferase Pi by 4-(Fluorosulfonyl)benzoic Acid

1999 • 9 citations

Disposition of 1,2-[14C]Dibromoethane in male Wistar rats.

1998 • 8 citations

Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine.

1997 • 6 citations

Inhibitory effects in vitro of S-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]-glutathione, a proposed metabolite of l-histidine, on γ-glutamyltransferase activity

1998 • 4 citations