Redox signaling: hydrogen peroxide as intracellular messenger

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

NF-κB: Ten Years After

1996 • 3,008 citations

H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

1994 • 2,757 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Active Oxygen Species in the Induction of Plant Systemic Acquired Resistance by Salicylic Acid

1993 • 1,186 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Methionine residues as endogenous antioxidants in proteins

1996 • 1,005 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

1998 • 891 citations

Metal-catalyzed oxidation of proteins. Physiological consequences

1991 • 877 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Reactive oxygen species and programmed cell death

1996 • 745 citations

Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

1994 • 743 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Interaction of reactive oxygen species with ion transport mechanisms

1998 • 659 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

The isolation and purification of a specific “protector” protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system.

1988 • 483 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Characterization of a Mammalian Peroxiredoxin That Contains One Conserved Cysteine

1998 • 439 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

1997 • 414 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.

1994 • 309 citations

Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae

1993 • 299 citations

Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

1996 • 283 citations

Neutrophil signal transduction and activation of the respiratory burst

1993 • 262 citations

Oxygen and the control of gene expression

1994 • 245 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes.

1979 • 196 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Roles of Aspartic Acid-181 and Serine-222 in Intermediate Formation and Hydrolysis of the Mammalian Protein-Tyrosine-Phosphatase PTP1

1997 • 176 citations

Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts

1998 • 171 citations

Reactive oxygen species and programmed cell death

1996 • 147 citations

Redox Signal Transduction: Mutations Shifting [2Fe-2S] Centers of the SoxR Sensor-Regulator to the Oxidized Form

1997 • 139 citations

Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells

1995 • 137 citations

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

1994 • 121 citations

Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate

1993 • 115 citations

On the protective mechanism of the thiol-specific antioxidant enzyme against the oxidative damage of biomacromolecules.

1994 • 104 citations

Production of hydrogen peroxide by murine epidermal keratinocytes following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1990 • 64 citations

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

2006 • 56 citations

Regulation of Bacterial Responses to Oxidative Stress

1997 • 42 citations

Living and dying with reactive speciesFocus on “Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease”

1998 • 30 citations

Characterization of regulatory elements on the promoter region of human ATP-citrate lyase

1999 • 22 citations

Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin

1999 • 12 citations