The protein disulphide-isomerase family: unravelling a string of folds

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

THIOREDOXIN

1985 • 1,885 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

Protein disulfide isomerase

2004 • 764 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1985 • 622 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

The ERO1 Gene of Yeast Is Required for Oxidation of Protein Dithiols in the Endoplasmic Reticulum

1998 • 482 citations

Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity.

1990 • 461 citations

Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver

1963 • 439 citations

Ero1p: A Novel and Ubiquitous Protein with an Essential Role in Oxidative Protein Folding in the Endoplasmic Reticulum

1998 • 438 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

1995 • 430 citations

Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.

1987 • 420 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

Crystal structure of the DsbA protein required for disulphide bond formation in vivo

1993 • 387 citations

Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins

1997 • 387 citations

Calnexin, calreticulin and the folding of glycoproteins

1997 • 377 citations

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer

1996 • 376 citations

Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution

1998 • 370 citations

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

1990 • 369 citations

Structural and functional relations among thioredoxins of different species

1991 • 363 citations

The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins

1998 • 332 citations

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

1998 • 329 citations

Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin

1996 • 289 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

Guidebook to Molecular Chaperones and Protein-Folding Catalysts

1997 • 275 citations

The unfolded protein response: an intracellular signalling pathway with many surprising features

1998 • 274 citations

Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds.

1994 • 268 citations

Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme.

1994 • 267 citations

Escherichia coli thioredoxin: a subunit of bacteriophage T7 DNA polymerase.

1976 • 267 citations

Oligosaccharide Binding Characteristics of the Molecular Chaperones Calnexin and Calreticulin

1998 • 260 citations

Molecular cloning and complete amino-acid sequence of form-I phosphoinositide-specific phospholipase C

1988 • 258 citations

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

1990 • 254 citations

Redox properties of protein disulfide isomerase (dsba) from escherichia coli

1993 • 242 citations

Identification of a set of calcium-binding proteins in reticuloplasm, the luminal content of the endoplasmic reticulum

1988 • 238 citations

Protein Disulfide Isomerase as a Regulator of Chloroplast Translational Activation

1997 • 238 citations

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase.

1993 • 235 citations

Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum

1998 • 235 citations

The folding catalyst protein disulfide isomerase is constructed of active and inactive thioredoxin modules

1997 • 216 citations

Building bridges: disulphide bond formation in the cell

1994 • 213 citations

Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase

1993 • 211 citations

The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds

1995 • 205 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

Four Intracisternal Calcium-binding Glycoproteins from Rat Liver Microsomes with High Affinity for Calcium

1989 • 200 citations

Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.

1979 • 199 citations

Conformation-Independent Binding of Monoglucosylated Ribonuclease B to Calnexin

1997 • 195 citations

Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer protein

1991 • 192 citations

A single dipeptide sequence modulates the redox properties of a whole enzyme family

1998 • 190 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

Determination of the reduction-oxidation potential of the thioredoxin-like domains of protein disulfide-isomerase from the equilibrium with glutathione and thioredoxin

1993 • 188 citations

Effects of Buried Charged Groups on Cysteine Thiol Ionization and Reactivity in Escherichia coli Thioredoxin: Structural and Functional Characterization of Mutants of Asp 26 and Lys 57

1997 • 187 citations

The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion.

1990 • 186 citations

The CXXC motif: imperatives for the formation of native disulfide bonds in the cell.

1996 • 173 citations

The multi-domain structure of protein disulfide isomerase is essential for high catalytic efficiency

1998 • 170 citations

Secretion, Surface Localization, Turnover, and Steady State Expression of Protein Disulfide Isomerase in Rat Hepatocytes

1995 • 154 citations

Chaperone‐Like Activity of Protein Disulfide‐Isomerase in the Refolding Of Rhodanese

1995 • 153 citations

Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in Spodoptera frugiperda insect cells.

1992 • 152 citations

Catalysis of Oxidative Protein Folding by Mutants of Protein Disulfide Isomerase with a Single Active-Site Cysteine

1996 • 151 citations

Multiple Molecular Chaperones Complex with Misfolded Large Oligomeric Glycoproteins in the Endoplasmic Reticulum

1997 • 151 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity.

1992 • 144 citations

Functional properties of the individual thioredoxin-like domains of protein disulfide isomerase

1995 • 142 citations

Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast.

1991 • 137 citations

Protein disulfide-isomerase in rat exocrine pancreatic cells is exported from the endoplasmic reticulum despite possessing the retention signal.

1990 • 131 citations

Peptide binding to protein disulfide isomerase occurs at a site distinct from the active sites.

1993 • 129 citations

Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia.

1996 • 128 citations

Molecular Cloning of the Human Glucose‐Regulated Protein ERp57/GRP58, a Thiol‐Dependent Reductase

1995 • 127 citations

[3] Protein disulfide isomerase

1998 • 126 citations

The Thiol-dependent Reductase ERp57 Interacts Specifically with N-Glycosylated Integral Membrane Proteins

1997 • 125 citations

Independence of the Chaperone Activity of Protein Disulfide Isomerase from Its Thioredoxin-like Active Site

1995 • 124 citations

Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae

1991 • 123 citations

A new Escherichia coli gene, dsbG, encodes a periplasmic protein involved in disulphide bond formation, required for recycling DsbA/DsbB and DsbC redox proteins

1997 • 122 citations

Electrostatic Interactions in the Active Site of the N-Terminal Thioredoxin-like Domain of Protein Disulfide Isomerase

1996 • 118 citations

Scanning and Escape during Protein-disulfide Isomerase-assisted Protein Folding

1997 • 115 citations

Interaction of Calreticulin with Protein Disulfide Isomerase

1995 • 115 citations

Both the isomerase and chaperone activities of protein disulfide isomerase are required for the reactivation of reduced and denatured acidic phospholipase A2

1997 • 115 citations

In vivo cross-linking of protein disulfide isomerase to immunoglobulins

1987 • 113 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit.

1993 • 112 citations

A Possible Role of ER-60 Protease in the Degradation of Misfolded Proteins in the Endoplasmic Reticulum

1995 • 111 citations

Comparison of the activities of protein disulphide-isomerase and thioredoxin in catalysing disulphide isomerization in a protein substrate

1991 • 111 citations

A Pro to His mutation in active site of thioredoxin increases its disulfide-isomerase activity 10-fold. New refolding systems for reduced or randomly oxidized ribonuclease.

1992 • 110 citations

Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes.

1985 • 107 citations

The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase.

1994 • 104 citations

Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation.

1994 • 104 citations

Highly conserved glucose-regulated protein in hamster and chicken cells: preliminary characterization of its cDNA clone.

1981 • 102 citations

General Acid/Base Catalysis in the Active Site of Escherichia coli Thioredoxin

1997 • 101 citations

Protein degradation by the phosphoinositide-specific phospholipase C-alpha family from rat liver endoplasmic reticulum.

1992 • 100 citations

The formation of protein disulphide bonds

1995 • 100 citations

cDNA Cloning and Baculovirus Expression of the Human Liver Endoplasmic Reticulum P58: Characterization as a Protein Disulfide Isomerase Isoform, but Not as a Protease or a Carnitine Acyltransferase

1995 • 97 citations

Protein disulfide isomerase mutant lacking its isomerase activity accelerates protein folding in the cell

1995 • 95 citations

A stress‐inducible rat liver endoplasmic reticulum protein, ERp29

1998 • 95 citations

Selective Inhibition of Protein Disulfide Isomerase by Estrogens

1989 • 94 citations

Interactions Between Protein Disulphide Isomerase and Peptides

1997 • 94 citations

Mutations in the thioredoxin sites of protein disulfide isomerase reveal functional nonequivalence of the N- and C-terminal domains.

1994 • 93 citations

Effects of DsbA on the Disulfide Folding of Bovine Pancreatic Trypsin Inhibitor and .alpha.-Lactalbumin

1994 • 92 citations

Influence of protein disulfide isomerase (PDI) on antibody folding in vitro.

1994 • 91 citations

Effects of CaBP2, the rat analog of ERp72, and of CaBP1 on the refolding of denatured reduced proteins. Comparison with protein disulfide isomerase.

1994 • 90 citations

Effect of protein and peptide inhibitors on the activity of protein disulfide-isomerase

1991 • 87 citations

Eukaryotic Protein Disulfide Isomerase Complements Escherichia coli dsbA Mutants and Increases the Yield of a Heterologous Secreted Protein with Disulfide Bonds

1996 • 86 citations

ERp28, a human endoplasmic‐reticulum‐lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin‐box motif

1998 • 83 citations

Dissecting the Mechanism of Protein Disulfide Isomerase: Catalysis of Disulfide Bond Formation in a Model Peptide

1994 • 83 citations

Proton Sharing between Cysteine Thiols in Escherichia coli Thioredoxin: Implications for the Mechanism of Protein Disulfide Reduction

1995 • 82 citations

Two resident ER‐proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase

1995 • 81 citations

Molecular cloning of ERp29, a novel and widely expressed resident of the endoplasmic reticulum

1997 • 80 citations

The uncharged surface features surrounding the active site ofEscherichia coliDsbA are conserved and are implicated in peptide binding

1997 • 79 citations

Active Site Mutations in Yeast Protein Disulfide Isomerase Cause Dithiothreitol Sensitivity and a Reduced Rate of Protein Folding in the Endoplasmic Reticulum

1997 • 79 citations

A 30-Amino Acid Truncation of the Microsomal Triglyceride Transfer Protein Large Subunit Disrupts Its Interaction with Protein Disulfide-isomerase and Causes Abetalipoproteinemia

1995 • 78 citations

Complex, Two-way Traffic of Molecules Across the Membrane of the Endoplasmic Reticulum

1998 • 77 citations

Characterization and Chromosomal Localization of a New Protein Disulfide Isomerase, PDIp, Highly Expressed in Human Pancreas

1996 • 76 citations

Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae.

1996 • 76 citations

Purification and characterization of a new isozyme of thiol:protein-disulfide oxidoreductase from rat hepatic microsomes. Relationship of this isozyme to cytosolic phosphatidylinositol-specific phospholipase C form 1A.

1991 • 76 citations

Efficient Catalysis of Disulfide Formation During Protein Folding with a Single Active-site Cysteine

1995 • 74 citations

Localized Requirements for windbeutel and pipe Reveal a Dorsoventral Prepattern within the Follicular Epithelium of the Drosophila Ovary

1998 • 73 citations

A Heterodimer of Thioredoxin and IB2 Cooperates with Sec18p (NSF) to Promote Yeast Vacuole Inheritance

1997 • 73 citations

Cloning and nucleotide sequence of the trxA gene of Escherichia coli K-12

1985 • 72 citations

Protein degradation by ERp72 from rat and mouse liver endoplasmic reticulum.

1993 • 72 citations

windbeutel,a gene required for dorsoventral patterning inDrosophila,encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum

1998 • 67 citations

The role of protein disulphide isomerase in the microsomal triacylglycerol transfer protein does not reside in its isomerase activity

1996 • 67 citations

Folding in vitro of bovine pancreatic trypsin inhibitor in the presence of proteins of the endoplasmic reticulum

1992 • 65 citations

ERp61 Is GRP58, a Stress-Inducible Luminal Endoplasmic Reticulum Protein, but Is Devoid of Phosphatidylinositide-Specific Phospholipase C Activity

1994 • 64 citations

Dictyostelium discoideum protein disulfide isomerase, an endoplasmic reticulum resident enzyme lacking a KDEL‐type retrieval signal

1997 • 62 citations

Protein Disulphide Isomerase and a Lumenal Cyclophilin‐Type Peptidyl Prolyl Cis‐Trans Isomerase are in Transient Contact with Secretory Proteins During Late Stages of Translocation

1995 • 62 citations

Molecular cloning of the cDNA encoding a novel protein disulfide isomerase‐related protein (PDIR)

1995 • 61 citations

Inhibition by acidic phospholipids of protein degradation by ER‐60 protease, a novel cysteine protease, of endoplasmic reticulum

1992 • 61 citations

CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity

1993 • 60 citations

A Novel Function of Escherichia coli Chaperone DnaJ

1995 • 59 citations

Protein disulfide isomerase associates with misfolded human lysozyme in vivo.

1994 • 57 citations

A major phosphoprotein of the endoplasmic reticulum is protein disulfide isomerase.

1994 • 56 citations

Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme.

1994 • 56 citations

Molecular Structure of a Yeast Gene, PDI1, Encoding Protein Disulfide Isomerase That Is Essential for Cell Growth

1991 • 54 citations

<scp>III</scp>. Yeast sequencing reports. Determination of the sequence of the yeast YCL313 gene localized on chromosome III. Homology with the protein disulfide isomerase (PDI gene product) of other organisms

1991 • 54 citations

Hormonal regulation of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes.

1993 • 54 citations

Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum

1997 • 54 citations

[38] Protein disulfide-isomerase

1995 • 52 citations

Rescue of Immunoglobulins from Insolubility Is Facilitated by PDI in the Baculovirus Expression System

1996 • 50 citations

Functional replacement of the Saccharomyces cerevisiae Trg1/Pdi1 protein by members of the mammalian protein disulfide isomerase family.

1993 • 50 citations

A pancreas‐specific glycosylated protein disulphide‐isomerase binds to misfolded proteins and peptides with an interaction inhibited by oestrogens

1998 • 50 citations

Molecular Characterization of a Pancreas-Specific Protein Disulfide Isomerase, PDIp

1997 • 48 citations

HIP-70: a protein induced by estrogen in the brain and LH-RH in the pituitary

1990 • 45 citations

A stress-regulated protein, GRP58, a member of thioredoxin superfamily, is a carnitine palmitoyltransferase isoenzyme

1994 • 45 citations

ERp60 does not substitute for protein disulphide isomerase as the β-subunit of prolyl 4-hydroxylase

1996 • 44 citations

Protein Disulfide Isomerase and Newly Synthesized Procollagen Chains form Higher-order Structures in the Lumen of the Endoplasmic Reticulum

1997 • 44 citations

CaBP1, a calcium binding protein of the thioredoxin family, is a resident KDEL protein of the ER and not of the intermediate compartment

1994 • 43 citations

The Saccharomyces cerevisiae TRG1 gene is essential for growth and encodes a lumenal endoplasmic reticulum glycoprotein involved in the maturation of vacuolar carboxypeptidase.

1991 • 43 citations

Nucleotide sequence of the thioredoxin gene from Escherichia coli

1984 • 39 citations

The gene for a novel protein, a member of the protein disulphide isomerase/form I phosphoinositide-specific phospholipase C family, is amplified in hydroxyurea-resistant cells

1992 • 39 citations

Prolyl 4-Hydroxylase: Defective Assembly of .alpha.-Subunit Mutants Indicates That Assembled .alpha.-Subunits Are Intramolecularly Disulfide Bonded

1994 • 39 citations

A Mutant Truncated Protein Disulfide Isomerase with No Chaperone Activity

1997 • 38 citations

ATP Binding and Hydrolysis by the Multifunctional Protein Disulfide Isomerase

1996 • 37 citations

Glutathione-Dependent Pathways of Refolding of RNase T₁ by Oxidation and Disulfide Isomerization: Catalysis by Protein Disulfide Isomerase^,

1996 • 37 citations

Functions of Characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) Motifs of Microsomal ER-60 Protease

1997 • 37 citations

The transient association of ERp57 with N‐glycosylated proteins is regulated by glucose trimming

1998 • 36 citations

The Yeast EUG1 Gene Encodes an Endoplasmic Reticulum Protein That Is Functionally Related to Protein Disulfide Isomerase

1992 • 35 citations

Protein folding: A missing redox link in the endoplasmic reticulum

1998 • 34 citations

Dependence of the anti-chaperone activity of protein disulphide isomerase on its chaperone activity

1997 • 29 citations

Pancreas specific protein disulfide isomerase, PDIp, is in transient contact with secretory proteins during late stages of translocation

1997 • 29 citations

Thioredoxin Domain Non-equivalence and Anti-chaperone Activity of Protein Disulfide Isomerase Mutants in Vivo

1997 • 25 citations

Novel Covalent Chaperone Complexes Associated with Human Chorionic Gonadotropin β Subunit Folding Intermediates

1996 • 23 citations

Distinct distribution of protein disulfide isomerase family proteins in rat tissues.

1996 • 22 citations

Elevated expression of PDI family proteins during differentiation of mouse F9 teratocarcinoma cells

1998 • 21 citations

The catalytic mechanism of the hydroxylation reaction of peptidyl proline and lysine does not require protein disulphide-isomerase activity

1989 • 18 citations

Hormonal regulation of protein disulfide isomerase and chaperone synthesis in the rat exocrine pancreas.

1994 • 18 citations

Tissue Distribution of ERp61 and Association of Its Increased Expression with IgG Production in Hybridoma Cells

1994 • 18 citations

Carnitine medium/long chain acyltransferase of microsomes seems to be the previously cloned ?54 kDa protein of unknown function

1993 • 16 citations

NF-Y, a CCAAT Box-Binding Protein, Is One of the Trans-Acting Factors Necessary for the Response of the Murine ERp72 Gene to Protein Traffic

1997 • 13 citations

Tissue distribution and molecular heterogeneity of bovine thiol:Protein-disulphide oxidoreductase (disulphide interchange enzyme)

1987 • 11 citations

HIP-70: a protein induced by estrogen in the brain and LH-RH in the pituitary

1990 • 10 citations

Retina cognin, cell signaling, and neuronal differentiation in the developing retina

1993 • 8 citations

Developmental localization of retina cognin synthesis by in situ hybridization

1997 • 6 citations