Is ascorbic acid an antioxidant for the plasma membrane?

Electron paramagnetic resonance of transition ions

1970 • 9,043 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate

1993 • 2,350 citations

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1974 • 1,028 citations

A COLORIMETRIC MICRO-METHOD FOR THE DETERMINATION OF GLUTATHIONE

1965 • 625 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid

1993 • 496 citations

The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective

1994 • 487 citations

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1985 • 447 citations

Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

1985 • 428 citations

Reduction of Dehydroascorbate to Ascorbate by the Selenoenzyme Thioredoxin Reductase

1997 • 331 citations

Protection and Recycling of α-Tocopherol in Human Erythrocytes by Intracellular Ascorbic Acid

1998 • 315 citations

Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein

1990 • 297 citations

Formation of α-tocopherol radical and recycling of α-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomesAn electron paramagnetic resonance study

1984 • 270 citations

A sensitive and simple method for determination of ferrocyanide

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The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration

1982 • 225 citations

Mechanism of free radical formation and disappearance during the ascorbic acid oxidase and peroxidase reactions

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1982 • 206 citations

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Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

1990 • 194 citations

Erythrocyte Ascorbate Recycling: Antioxidant Effects in Blood

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1990 • 180 citations

Transport of ascorbic acid and other water-soluble vitamins

1988 • 179 citations

Coenzyme Q reductase from liver plasma membrane: purification and role in trans-plasma-membrane electron transport.

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Reversible association of cytochalasin B with the human erythrocyte membrane. Inhibition of glucose transport and the stoichiometry of cytochalasin binding

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Resolution of the Facilitated Transport of Dehydroascorbic Acid from Its Intracellular Accumulation as Ascorbic Acid

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Unequivocal evidence in support of the nonenzymatic redox coupling between glutathione/glutathione disulfide and ascorbic acid/dehydroascorbic acid

1992 • 160 citations

Antioxidant action of ubiquinol homologues with different isoprenoid chain length in biomembranes

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Electron transfer across the chromaffin granule membrane.

1983 • 148 citations

An ascorbate-mediated transmembrane-reducing system of the human erythrocyte.

1979 • 133 citations

Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.

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Vitamins C and E donate single hydrogen atoms in vivo

1991 • 128 citations

Ascorbic Acid Recycling Enhances the Antioxidant Reserve of Human Erythrocytes

1995 • 119 citations

Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake.

1993 • 115 citations

One-electron-transfer reactions in biochemical systems II. The reaction of free radicals formed in the enzymic oxidation

1969 • 113 citations

One-electron oxidation-reduction properties of ascorbic acid

1985 • 105 citations

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Electron and proton transport across the plasma membrane

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Vectorial redox reactions of physiological quinones I. Requirement of a minimum length of the isoprenoid side chain

1979 • 92 citations

Enzyme-Dependent Ascorbate Recycling in Human Erythrocytes: Role of Thioredoxin Reductase

1998 • 91 citations

The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity

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Ascorbate function at the plasma membrane

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Cytochrome b561 catalyzes transmembrane electron transfer.

1984 • 83 citations

Interaction of Ascorbate and α-Tocopherol in Resealed Human Erythrocyte Ghosts

1996 • 83 citations

A Phospholipid-Dependent NADH-Coenzyme Q Reductase from Liver Plasma Membrane

1995 • 81 citations

Ascorbate Stimulates Ferricyanide Reduction in HL-60 Cells through a Mechanism Distinct from the NADH-dependent Plasma Membrane Reductase

1998 • 80 citations

Ascorbate is regenerated by HL-60 cells through the transplasmalemma redox system

1991 • 79 citations

Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in the plasma membrane.

1997 • 76 citations

The relation between membrane structure and NADH: (Acceptor) oxidoreductase activity of erythrocyte ghosts

1969 • 75 citations

Induction of intracellular ATP synthesis by extracellular ferricyanide in human red blood cells

1969 • 74 citations

Extracellular Ferrireductase Activity of K562 Cells is Coupled to Transferrin-Independent Iron Transport

1994 • 73 citations

Tocopheroxyl Radical Persistence and Tocopherol Consumption in Liposomes and in Vitamin E-enriched Rat Liver Mitochondria and Microsomes

1989 • 72 citations

Subcellular distribution of ascorbate in bovine adrenal medullaEvidence for accumulation in chromaffin granules against a concentration gradient

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The Passage of Vitamin C across the Erythrocyte Membrane

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Ascorbic acid and catecholamine secretion from cultured chromaffin cells.

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¹³C NMR Studies of Vitamin C Transport and Its Redox Cycling in Human Erythrocytes

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1986 • 63 citations

[4] Glutathione : Dehydroascorbate oxidoreductases

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Transplasma membrane redox stimulates HeLa cell growth

1984 • 59 citations

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1981 • 56 citations

A transmembranous NADH-dehydrogenase in human erythrocyte membranes

1984 • 55 citations

Plasto‐ and ubiquinone as translocators of electrons and protons through membranes A facilitating role of the isoprenoid side chain

1977 • 51 citations

Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids

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Growth factor‐stimulated trans plasma membrane electron transport in HL‐60 cells

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Purification and properties of human erythrocyte membrane NADH-cytochrome b5 reductase

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Plasma Membrane Redox Enzymes

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Untersuchungen zum mikrosomalen NADH-abhängigen Elektronentransport

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Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells

1999 • 41 citations

NADH-ascorbate free radical and -ferricyanide reductase activities represent different levels of plasma membrane electron transport

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Reduction of extracellular potassium ferricyanide by transmembrane NADH: (Acceptor) oxidoreductase of human erythrocytes

1985 • 39 citations

Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes

1976 • 39 citations

The mechanism of insulin action: the immediate electrochemical effects of insulin on red‐cell systems.

1965 • 39 citations

Monodehydroascorbate reductase activity in the surface membrane of leukemic cells

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Plasma membranes from intestinal microvilli and erythrocytes contain cytochromes b5 and P-420

1980 • 34 citations

Evidence for a plasma membrane redox system on intact ascites tumor cells with different metastatic capacity

1981 • 34 citations

COMPLEXES OF DEHYDROASCORBIC ACID WITH THREE SULFHYDRYL COMPOUNDS

1942 • 33 citations

Ascorbate‐mediated transmembrane electron transport and ascorbate uptake in leukemic cell lines are two different processes

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Isolation and partial characterization of human erythrocyte membrane NADH: (Acceptor) oxidoreductase

1978 • 32 citations

Transduction of reducing power across the plasma membrane by reduced glutathione

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Transplasma membrane redox system of HL-60 cells is controlled by cAMP.

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1997 • 29 citations

NADH-monodehydroascorbate reductase in human erythrocyte membranes.

1983 • 28 citations

Kinetic behavior of the monodehydroascorbate radical studied by pulse radiolysis

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Properties and regulation of a trans-plasma membrane redox system in rat liver

1982 • 25 citations

Liposomes Containing α-Tocopherol and Ascorbate are Protected from an External Oxidant Stress

1997 • 23 citations

Diffusion- and reaction rate-limited redox processes mediated by quinones through bilayer lipid membranes

1987 • 20 citations

Clinical analysis in intact erythrocytes using 1H spin echo NMR

1991 • 20 citations

Asymmetric binding of cytochrome b5 to the membrane of human erythrocyte ghosts

1977 • 20 citations

No enzymatic activities are necessary for the stabilization of ascorbic acid by K‐562 cells

1993 • 17 citations

Purification and properties of S-protein (hemoprotein 559) from human erythrocytes

1971 • 17 citations

Specific binding to plasma membrane is the first step in the uptake of non-transferrin iron by cultured cells

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Reduction of extracellular dehydroascorbic acid by K562 cells

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A Novel Lipid Hydroperoxide-Reducing Enzyme in Human Erythrocyte Membranes

1979 • 10 citations

Functional Reconstitution of Ehrlich Cell Plasma Membrane Ferricyanide Reductase

1994 • 8 citations