Arsenicals Inhibit Thioredoxin Reductase in Cultured Rat Hepatocytes

Applied Regression Analysis and Other Multivariable Methods

1989 • 8,685 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Arsenic: exposure and health effects

1998 • 797 citations

Monomethylarsonous Acid (MMAIII) Is More Toxic Than Arsenite in Chang Human Hepatocytes

2000 • 707 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

Preparation of rat liver cells

1973 • 578 citations

Human Placenta Thioredoxin Reductase

1998 • 519 citations

The role of the redox protein thioredoxin in cell growth and cancer

2000 • 443 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

Arsenic in the environment part II: Human health and ecosystem effects

1995 • 392 citations

Reduction of Dehydroascorbate to Ascorbate by the Selenoenzyme Thioredoxin Reductase

1997 • 331 citations

Changes in the chemical speciation of arsenic following ingestion by man.

1977 • 330 citations

Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

1995 • 315 citations

Comparative Inhibition of Yeast Glutathione Reductase by Arsenicals and Arsenothiols

1997 • 302 citations

Arsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cells

1996 • 281 citations

Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis

2000 • 271 citations

Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity.

1990 • 268 citations

Separation and Purification

1977 • 241 citations

Methylarsenicals and Arsinothiols Are Potent Inhibitors of Mouse Liver Thioredoxin Reductase

1999 • 230 citations

Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase.

1992 • 206 citations

Enzymatic Methylation of Arsenic Compounds

1996 • 161 citations

Preparation and purification of 74As-labeled arsenate and arsenite for use in biological experiments

1977 • 152 citations

Metabolism of Arsenic in Primary Cultures of Human and Rat Hepatocytes

1999 • 143 citations

The reduction of trimethylarsine oxide to trimethylarsine by thiols: a mechanistic model for the biological reduction of arsenicals

1984 • 135 citations

Airborne arsenic exposure and excretion of methylated arsenic compounds.

1977 • 135 citations

Enzymatic Reduction of Arsenic Compounds in Mammalian Systems: Reduction of Arsenate to Arsenite by Human Liver Arsenate Reductase

1999 • 129 citations

Comparative in Vitro Methylation of Trivalent and Pentavalent Arsenicals

1995 • 121 citations

Enzymatic Reduction of Arsenic Compounds in Mammalian Systems: The Rate-Limiting Enzyme of Rabbit Liver Arsenic Biotransformation Is MMA^V Reductase

1999 • 116 citations

Interaction of Gold(I) with the Active Site of Selenium-Glutathione Peroxidase

1984 • 111 citations

Enzymatic Methylation of Arsenic Compounds. VII. Monomethylarsonous Acid (MMAIII) Is the Substrate for MMA Methyltransferase of Rabbit Liver and Human Hepatocytes

1999 • 108 citations

Complexation of Arsenic Species in Rabbit Erythrocytes

1994 • 103 citations

Binding of Arsenicals to Proteins in anin VitroMethylation System

1997 • 88 citations

DYNAMIC CHANGE OF INORGANIC ARSENIC AND METHYLARSENIC COMPOUNDS IN HUMAN URINE AFTER ORAL INTAKE AS ARSENIC TRIOXIDE

1979 • 74 citations

Evidence that Cysteine, not Selenocysteine, is in the Catalytic Site of Type II Iodothyronine Deiodinase

1991 • 72 citations

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeastSchizosaccharomyces pombe

1996 • 71 citations

Liberation and analysis of protein-bound arsenicals

1996 • 69 citations

Arsenic Trioxide Inhibits Neuroblastoma Growth in Vivo and Promotes Apoptotic Cell Death in Vitro

2000 • 67 citations

Aurothioglucose Inhibits Murine Thioredoxin Reductase Activity In Vivo

1999 • 67 citations

Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase.

2000 • 58 citations

Dehydroascorbic acid uptake in a human keratinocyte cell line (HaCaT) is glutathione-independent

2000 • 57 citations

Time dependence of accumulation and binding of inorganic and organic arsenic species in rabbit erythrocytes

1995 • 50 citations

Induction of mitosis-mediated apoptosis by sodium arsenite in HeLa S3 cells

2000 • 40 citations

Metabolism and Toxicity of Arsenicals in Cultured Cells

1999 • 35 citations

The interferon-β and tamoxifen combination induces apoptosis using thioredoxin reductase

2000 • 29 citations

Identification of methylated metabolites of inorganic arsenic by thin-layer chromatography

1995 • 27 citations