Repression of gene expression by oxidative stress

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,443 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Oxidative stress: the paradox of aerobic life

1995 • 1,152 citations

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

1993 • 1,126 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Methionine residues as endogenous antioxidants in proteins

1996 • 1,005 citations

Oxidative Decay of DNA

1997 • 938 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Antioxidant Functions of Vitamins

1992 • 810 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide

1997 • 577 citations

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

1993 • 520 citations

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1997 • 485 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Regulation of Cytochromes P450 During Inflammation and Infection

1997 • 477 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Oxygen Sensing, Hypoxia-Inducible Factor-1 and the Regulation of Mammalian Gene Expression

1998 • 362 citations

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.

1997 • 356 citations

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1998 • 347 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

1995 • 339 citations

The ER-overload response: activation of NF-κB

1997 • 334 citations

Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants.

1996 • 323 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Transient Adaptation to Oxidative Stress in Mammalian Cells

1995 • 300 citations

(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

1999 • 297 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage

1997 • 273 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

Protein‐sulfenic acid stabilization and function in enzyme catalysis and gene regulation

1993 • 250 citations

Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

1996 • 250 citations

Production of Reactive Oxygen Species by Microsomes Enriched in Specific Human Cytochrome P450 Enzymes

1998 • 244 citations

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1995 • 242 citations

Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α

1999 • 241 citations

Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB

1996 • 234 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease

1998 • 231 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

Zonation of hepatic cytochrome P-450 expression and regulation

1998 • 214 citations

Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

1999 • 205 citations

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

1996 • 202 citations

sigma R, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2)

1998 • 201 citations

Down-regulation of Cytochrome P450 1A1 Gene Promoter by Oxidative Stress

1998 • 200 citations

Physical and Functional Sensitivity of Zinc Finger Transcription Factors to Redox Change

1996 • 192 citations

Role for NF-κB in the Regulation of Ferritin H by Tumor Necrosis Factor-α

1995 • 188 citations

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.

1997 • 181 citations

Peroxynitrite

1998 • 181 citations

Iron Regulatory Proteins, Iron Responsive Elements and Iron Homeostasis ,

1998 • 179 citations

Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression

1998 • 178 citations

Redox-dependent Regulation of Nuclear Import of the Glucocorticoid Receptor

1999 • 178 citations

Adaptive response and oxidative stress.

1994 • 175 citations

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.

1997 • 170 citations

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

1996 • 170 citations

Regulation of p53 by Metal Ions and by Antioxidants: Dithiocarbamate Down-Regulates p53 DNA-Binding Activity by Increasing the Intracellular Level of Copper

1997 • 169 citations

Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis

1998 • 168 citations

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction

1997 • 166 citations

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

1997 • 164 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

Cytotoxicity and Apoptosis Produced by Cytochrome P450 2E1 in Hep G2 Cells

1998 • 162 citations

Thioltransferase (Glutaredoxin) Reactivates the DNA-binding Activity of Oxidation-inactivated Nuclear Factor I

1998 • 161 citations

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

1998 • 160 citations

The DNA‐Binding Efficiency of Sp1 is Affected by Redox Changes

1994 • 156 citations

Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-κB in vitro

1994 • 153 citations

Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway.

1996 • 148 citations

The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin

1994 • 143 citations

Redox Regulation of the DNA Binding Activity in Transcription Factor PEBP2

1997 • 143 citations

Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid

1997 • 143 citations

Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes.

1992 • 139 citations

Nitric Oxide–Mediated Induction of Ferritin Synthesis in J774 Macrophages by Inflammatory Cytokines: Role of Selective Iron Regulatory Protein-2 Downregulation

1998 • 137 citations

Recycling and Redox Cycling of Phenolic Antioxidants

1998 • 137 citations

The Effect of Long‐term Dietary Supplementation with Antioxidants^a

1998 • 136 citations

Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator

1997 • 133 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

In vivo kinetics of a redox-regulated transcriptional switch

1997 • 125 citations

Regulation of Cellular Iron Metabolism by Erythropoietin: Activation of Iron-Regulatory Protein and Upregulation of Transferrin Receptor Expression in Erythroid Cells

1997 • 125 citations

Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets

1998 • 123 citations

Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress.

1994 • 122 citations

Inhibition of AP-1 DNA Binding by Nitric Oxide Involving Conserved Cysteine Residues in Jun and Fos

1998 • 119 citations

Oxidative stress up-regulates IL-8 and TNF-α synthesis by human dendritic cells

1998 • 119 citations

Age-Related Decreases in IL-2 Production by Human T Cells Are Associated with Impaired Activation of Nuclear Transcriptional Factors AP-1 and NF-AT

1996 • 119 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction.

1994 • 113 citations

Effect of antioxidative vitamins on immune function with clinical applications.

1997 • 112 citations

Xbp1, a Stress-Induced Transcriptional Repressor of the Saccharomyces cerevisiae Swi4/Mbp1 Family

1997 • 107 citations

Redox Potential Controls the Structure and DNA Binding Activity of the Paired Domain

1998 • 107 citations

11. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress

1999 • 103 citations

Transforming growth factor beta 1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2.

1996 • 103 citations

Use of the inhibition of enzymatic antioxidant systems in order to evaluate their physiological importance

1988 • 100 citations

The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

1998 • 97 citations

Subunit Association and DNA Binding Activity of the Heterotrimeric Transcription Factor NF-Y Is Regulated by Cellular Redox

1996 • 97 citations

Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

1997 • 96 citations

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA

1997 • 95 citations

Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila

1998 • 94 citations

Antioxidant Vitamins in the Prevention of Cancer

1999 • 93 citations

Complete and Reversible Inhibition of NADPH Oxidase in Human Neutrophils by Phenylarsine Oxide at a Step Distal to Membrane Translocation of the Enzyme Subunits

1995 • 91 citations

Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor

1991 • 90 citations

Gene expression in liver after toxic injury: analysis of heat shock response and oxidative stress‐inducible genes

1997 • 87 citations

Electron Shuttle between Membrane-Bound Cytochrome P450 3A4 andb₅Rules Uncoupling Mechanisms

1998 • 84 citations

Identification of Residues in the Human DNA Repair Enzyme HAP1 (Ref-1) That are Essential for Redox Regulation of Jun DNA Binding

1993 • 84 citations

Redox Modulation of Iron Regulatory Proteins by Peroxynitrite

1997 • 83 citations

Direct Evidence for Intra- and Intermolecular Disulfide Bond Formation in the Human Glucocorticoid Receptor

1989 • 80 citations

Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species

1997 • 79 citations

Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production.

1998 • 76 citations

Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure

1998 • 76 citations

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator

1998 • 74 citations

The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines

1995 • 73 citations

Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection

1997 • 72 citations

Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins.

1994 • 72 citations

Hypoxia-inducible Factor 1α (HIF-1α) Is a Non-heme Iron Protein

1998 • 71 citations

Role of H₂O₂and heme-containing O₂sensors in hypoxic regulation of tyrosine hydroxylase gene expression

1998 • 70 citations

Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide

1996 • 70 citations

Converse Modulation of IRP1 and IRP2 by Immunological Stimuli in Murine RAW 264.7 Macrophages

1998 • 70 citations

Pyrrolidine Dithiocarbamate Prevents p53 Activation and Promotes p53 Cysteine Residue Oxidation

1998 • 68 citations

Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats

1998 • 65 citations

The Human Immunodeficiency Virus-1 Tat Protein Increases Cell Proliferation, Alters Sensitivity to Zinc Chelator-Induced Apoptosis, and Changes Sp1 DNA Binding in HeLa Cells

1999 • 63 citations

Role of Zinc-Coordination and of the Glutathione Redox Couple in the Redox Susceptibility of Human Transcription Factor Sp1

1994 • 63 citations

Restoration of the Glucocorticoid Receptor Function by the Phosphodiester Compound of Vitamins C and E, EPC-K1 (l-Ascorbic Acid 2-[3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl Hydrogen Phosphate] Potassium Salt), via a Redox-dependent Mechanism

1998 • 61 citations

Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells.

1996 • 59 citations

Physiological and pathophysiological regulation of cytochrome P450.

1998 • 59 citations

Glutathione Precursor and Antioxidant Activities ofN-Acetylcysteine and Oxothiazolidine Carboxylate Compared inin VitroStudies of HIV Replication

1994 • 58 citations

Tumor promotion by hydrogen peroxide in rat liver epithelial cells

1999 • 57 citations

Transcriptional Remodeling and G1 Arrest in Dioxygen Stress in Saccharomyces cerevisiae

1996 • 56 citations

Oxidant stress impaired DNA-binding of estrogen receptor from human breast cancer

1998 • 55 citations

DNA binding activity of the glucocorticoid receptor is sensitive to redox changes in intact cells

1995 • 55 citations

Effects of Pro- and Antioxidative Compounds on Renal Production of Erythropoietin*

1999 • 53 citations

Interleukin‐1β antagonizes phenobarbital induction of several major cytochromes P450 in adult rat hepatocytes in primary culture

1995 • 53 citations

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2

1997 • 51 citations

Glutathione Depletion in Human T Lymphocytes: Analysis of Activation-Associated Gene Expression and the Stress Response

1995 • 48 citations

Nucleocytoplasmic functionality of metallothionein.

1997 • 46 citations

Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation

1998 • 45 citations

Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides

1998 • 45 citations

Oxidative and Chemical Stress Mimic Insulin by Selectively Inhibiting the Expression of Phosphoenolpyruvate Carboxykinase in Hepatoma Cells

1997 • 41 citations

Selective Inhibition of Muscle Gene Expression by Oxidative Stress in Cardiac Cells

1998 • 38 citations

Folding topology of the disulfide-bonded dimeric DNA-binding domain of the myogenic determination factor MyoD

1992 • 36 citations

RNA fingerprinting displays UVB-specific disruption of transcriptional control in human melanocytes.

1997 • 33 citations

Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis

1998 • 33 citations

Inhibition of NADPH Oxidase-Mediated Superoxide Radical Formation in PMA-Stimulated Human Neutrophils by 4-Hydroxynonenal– Binding to -SH and -NH₂Groups

1997 • 33 citations

NADPH- and NADH-dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron

1990 • 29 citations

Autoregulation of human CYP1A1 gene promotor activity in HepG2 and MCF-7 cells

1996 • 29 citations

Tumorigenic conversion of a non-tumorigenic rat urothelial cell line by overexpression of H2O2-generating peroxisomal fatty acyl-CoA oxidase

1997 • 28 citations

Effect of Reactive Oxygen Species on Iron Regulatory Protein Activitya

1998 • 27 citations

Differential roles for Fos and Jun in DNA-binding: redoxdependent and independent functions

1993 • 27 citations

Suppression of constitutive cytochrome P450 gene expression by epidermal growth factor receptor ligands in cultured rat hepatocytes.

1996 • 25 citations

Redox‐regulated expression of glycolytic enzymes in resting and proliferating rat thymocytes

1997 • 24 citations

Protection by l-2-oxothiazolidine-4-carboxylic acid of hydrogen peroxide-induced CD3ζ and CD16ζ chain down-regulation in human peripheral blood lymphocytes and lymphokine-activated killer cells

1998 • 22 citations

Regulation of hepatic cytochrome P450 2C11 by transforming growth factor-beta, hepatocyte growth factor, and interleukin-11.

1998 • 20 citations

Suppression ofCYP1A1Transcription by H2O2Is Mediated by Xenobiotic-Response Element

1998 • 19 citations

A RIPE3b1‐like factor binds to a novel site in the human insulin promoter in a redox‐dependent manner

1997 • 17 citations

Effects of oxidation and reduction on the binding of transcription factors toCis-regulatory elements located in the FGF-4 gene

1996 • 16 citations

Transcriptional Activation and Redox Regulation of the Tumor Necrosis Factor-α Promoter in Human T Cells: Role of the CRE/κ3 Promoter Region

1998 • 13 citations

Studies on the Mechanism of Stimulation of Microsomal H2O2 Formation and Benzo(a)pyrene Hydroxylaton by Substrates and Flavone

1982 • 11 citations

Effects of Dietary Lipid Peroxidation Products on Hormonal Responses in Primary Cultured Hepatocytes of Rats

1997 • 4 citations

Demonstration of Drug-Ethanol Interactions by Changes in Activity of Hepatic Microsomal Oxidase/Oxygenase Cytochrome P-450 Function

1979 • 2 citations