Thioredoxin reductase

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Chemistry and Biochemistry of Flavoenzymes

2018 • 1,241 citations

Selective reduction of disulfides by tris(2-carboxyethyl)phosphine

1991 • 663 citations

Rat liver thioredoxin and thioredoxin reductase: purification and characterization

1982 • 610 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Human Placenta Thioredoxin Reductase

1998 • 519 citations

Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

2000 • 498 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations

2000 • 418 citations

Flavins and Flavoproteins

2021 • 391 citations

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 340 citations

Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases

1999 • 327 citations

The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

1983 • 323 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman

1999 • 236 citations

Twists in Catalysis: Alternating Conformations of Escherichia coli Thioredoxin Reductase

2000 • 228 citations

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

1997 • 227 citations

Crystal Structure of Escherichia coli Thioredoxin Reductase Refined at 2 Å Resolution

1994 • 220 citations

Cloning and sequencing of a human thioredoxin reductase

1995 • 211 citations

Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607

1991 • 201 citations

Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue

1998 • 199 citations

Convergent evolution of similar function in two structurally divergent enzymes

1991 • 191 citations

ROLE OF CHARGE‐TRANSFER INTERACTIONS IN FLAVOPROTEIN CATALYSIS

1974 • 185 citations

Flavins and Flavoproteins 1993

1994 • 182 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 Å resolution

1991 • 162 citations

Mechanism and structure of thioredoxin reductase from Escherichia coli

1995 • 147 citations

Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance

1989 • 145 citations

Nucleotide sequence and expression of the mercurial-resistance operon from Staphylococcus aureus plasmid pI258.

1987 • 138 citations

AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low M_r thioredoxin reductase

2000 • 134 citations

Cobalamin-Independent Methionine Synthase from Escherichia coli: A Zinc Metalloenzyme

1996 • 129 citations

Measurement of the oxidation-reduction potentials for two-electron and four-electron reduction of lipoamide dehydrogenase from pig heart.

1976 • 120 citations

Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements

1999 • 108 citations

Human thioredoxin reductase from HeLa cells: Selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

1998 • 100 citations

Crystal Structure ofArabidopsis thalianaNADPH Dependent Thioredoxin Reductase at 2.5 Å Resolution

1996 • 99 citations

Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase

1989 • 82 citations

A Stable Mixed Disulfide between Thioredoxin Reductase and Its Substrate, Thioredoxin: Preparation and Characterization

1996 • 74 citations

Differential reactivity of the two active site cysteine residues generated on reduction of pig heart lipoamide dehydrogenase.

1976 • 72 citations

Identification and Characterization of the Functional Amino Acids at the Active Site of the Large Thioredoxin Reductase fromPlasmodium falciparum

1997 • 59 citations

Recombinant putative glutathione reductase of Plasmodium falciparum exhibits thioredoxin reductase activity

1996 • 57 citations

Reductive Half-Reaction of Thioredoxin Reductase fromEscherichia coli

1997 • 53 citations

Alternative Routes for Entry of HgX₂ into the Active Site of Mercuric Ion Reductase Depend on the Nature of the X Ligands

1999 • 52 citations

Thioredoxin Reductase from Plasmodium falciparum: Evidence for Interaction between the C-Terminal Cysteine Residues and the Active Site Disulfide−Dithiol

1999 • 52 citations

Lipoamide dehydrogenase from pig heart. Pyridine nucleotide induced changes in monoalkylated two-electron reduced enzyme

1981 • 47 citations

A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalis

1996 • 46 citations

The role of the C‐terminus for catalysis of the large thioredoxin reductase from Plasmodium falciparum

1998 • 45 citations

The thioredoxin reductase system of mycoplasmas

1997 • 36 citations

Evidence for two conformational states of thioredoxin reductase from Escherichia coli: Use of intrinsic and extrinsic quenchers of flavin fluorescence as probes to observe domain rotation

1997 • 35 citations

News and views on thioredoxin reductases

1999 • 24 citations

Effect of Pyridine Nucleotide on the Oxidative Half-Reaction of Escherichia coli Thioredoxin Reductase

1995 • 21 citations

Thioredoxin reductase from Escherichia coli: Evidence of restriction to a single conformation upon formation of a crosslink between engineered cysteines

1998 • 20 citations