Targeted Deletion of the Cytosolic Cu/Zn-Superoxide Dismutase Gene (<i>Sod1</i>) Increases Susceptibility to Noise-Induced Hearing Loss

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

A cochlear frequency-position function for several species—29 years later

1990 • 1,801 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress

1994 • 1,178 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

1995 • 484 citations

Oxidative stress: Free radical production in neural degeneration

1994 • 483 citations

Reduction of CuZn-Superoxide Dismutase Activity Exacerbates Neuronal Cell Injury and Edema Formation after Transient Focal Cerebral Ischemia

1997 • 436 citations

Early Elevation of Cochlear Reactive Oxygen Species following Noise Exposure

1999 • 416 citations

A major gene affecting age-related hearing loss in C57BL/6J mice

1997 • 352 citations

Mechanism of Cisplatin Ototoxicity: Antioxidant System

1995 • 320 citations

Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants

1996 • 284 citations

Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma

1995 • 280 citations

Aging and the auditory system: anatomy, physiology, and psychophysics

1992 • 236 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

The protective effects of allopurinol and superoxide dismutase on noise‐induced cochlear damage

1993 • 207 citations

Scientific basis of noise-induced hearing loss

1996 • 192 citations

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase ( SOD1 ) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

1997 • 189 citations

Reactive oxygen species in chick hair cells after gentamicin exposure in vitro

1997 • 176 citations

Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss

1996 • 157 citations

Hydroxyl Radicals, Iron, Oxidative Stress, and Neurodegeneration^a

1994 • 141 citations

Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo

1994 • 140 citations

Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro

1994 • 89 citations

Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains

1998 • 83 citations

Superoxide dismutase activity in the cochlea

1982 • 76 citations

The Protective Effects of Allopurinol and Superoxide Dismutase‐Polyethylene Glycol on Ischemic and Reperfusion‐Induced Cochlear Damage

1991 • 76 citations

The Protective Effects of Tirilated Mesylate (U74006F) on Ischemic and Reperfusion‐Induced Cochlear Damage

1991 • 68 citations

Elevation of Reactive Oxygen Species following Ischemia-Reperfusion in Mouse Cochlea Observed in vivo

1999 • 68 citations

Influence of Genotype and Age on Acute Acoustic Trauma and Recovery in CBA/Ca and C57BL/6J Mice

1992 • 57 citations

Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum

1998 • 52 citations

Hereditary deafness occurring in cd/1 mice

1991 • 43 citations

Interaction of noise-induced permanent threshold shift and age-related threshold shift

1997 • 39 citations

Detection and regulation of and MnSOD in rat cochlear tissues

1996 • 33 citations

Background genes: out of sight, but not out of brain....

1997 • 24 citations

Cu,Zn-Superoxide Dismutase Gene Dosage and Cell Resistance to Oxidative Stress: A Review

1997 • 16 citations