Oxygen radicals and signaling

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Antioxidants and Atherosclerotic Heart Disease

1997 • 1,390 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

1996 • 851 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Reactive oxygen species and programmed cell death

1996 • 745 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells

1996 • 294 citations

Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro

1992 • 273 citations

Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells

1997 • 269 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Activity of Ubiquitin-dependent Pathway in Response to Oxidative Stress

1997 • 233 citations

Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

1992 • 232 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1

1995 • 171 citations

Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion

1995 • 170 citations

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1994 • 148 citations

Reactive oxygen species and programmed cell death

1996 • 147 citations

Gene Regulation by Reactive Oxygen Species

1997 • 105 citations

The functional expression of p47‐phox and p67‐phox may contribute to the generation of superoxide by an NADPH oxidase‐like system in human fibroblasts

1994 • 93 citations

Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells

1996 • 90 citations

Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB

1996 • 75 citations

Fas‐induced programmed cell death is mediated by a Ras‐regulated O₂⁻ synthesis

1996 • 75 citations

Regulation of Bacterial Responses to Oxidative Stress

1997 • 42 citations

Signal transduction in plant immunity

1996 • 31 citations

Study of Redox-Regulated Transcription Factors in Prokaryotes

1997 • 24 citations