Nitric oxide and the regulation of gene expression

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Mammalian nitric oxide synthases

1999 • 975 citations

Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity

2000 • 923 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

Nitric oxide and salicylic acid signaling in plant defense

2000 • 728 citations

Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)

1998 • 651 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Inhibition of NF- B DNA Binding by Nitric Oxide

1996 • 479 citations

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

1998 • 476 citations

Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

2000 • 445 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 421 citations

The oxyhemoglobin reaction of nitric oxide

1999 • 418 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1998 • 406 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite

2000 • 387 citations

Nitrosative Stress: Activation of the Transcription Factor OxyR

1996 • 351 citations

A molecular basis for nitric oxide sensing by soluble guanylate cyclase

1999 • 316 citations

Nitric oxide in excitable tissues: physiological roles and disease.

1997 • 312 citations

Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator

2000 • 304 citations

Nitric oxide (NO): an effector of apoptosis

1999 • 298 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

1999 • 270 citations

Redox sensing by prokaryotic transcription factors

2000 • 264 citations

Nitric Oxide Contributes to Behavioral, Cellular, and Developmental Responses to Low Oxygen in Drosophila

1999 • 257 citations

Inhibition of Endothelial Vascular Cell Adhesion Molecule-1 Expression by Nitric Oxide Involves the Induction and Nuclear Translocation of IκBα

1997 • 250 citations

Nitric Oxide Involvement in Drosophila Immunity

2000 • 245 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

Nitric Oxide and Infection

2002 • 223 citations

Linkage of cell-mediated immunity to iron metabolism

1995 • 209 citations

Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production

1999 • 204 citations

Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression

1997 • 202 citations

Requirement for Type 2 NO Synthase for IL-12 Signaling in Innate Immunity

1999 • 198 citations

Nitric oxide and cGMP analogs activate transcription from AP‐1‐responsive promoters in mammalian cells

1995 • 193 citations

Stimulation of the Cyclic GMP Pathway by NO Induces Expression of the Immediate Early Genes c‐fos and junB in PC12 Cells

1994 • 187 citations

Tyrosine Nitration by Peroxynitrite Formed from Nitric Oxide and Superoxide Generated by Xanthine Oxidase

2000 • 186 citations

A Redox-triggered Ras-Effector Interaction

1998 • 182 citations

Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.

1997 • 181 citations

Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).

1998 • 181 citations

NO is necessary and sufficient for egg activation at fertilization

2000 • 172 citations

Nitric Oxide Prevents IL-1β and IFN-γ-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1β-Converting Enzyme)

1998 • 159 citations

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

2000 • 156 citations

Nitric Oxide Inhibits c-Jun DNA Binding by Specifically TargetedS-Glutathionylation

1999 • 156 citations

Dityrosine Formation Outcompetes Tyrosine Nitration at Low Steady-state Concentrations of Peroxynitrite

2000 • 155 citations

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

1998 • 152 citations

Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells

2000 • 146 citations

Nitric Oxide Attenuates Vascular Smooth Muscle Cell Activation by Interferon-γ

1996 • 145 citations

Regulation of transforming growth factor beta1 by nitric oxide.

1999 • 142 citations

Effects of Interferon-γ and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2

2000 • 141 citations

Nitric Oxide–Mediated Induction of Ferritin Synthesis in J774 Macrophages by Inflammatory Cytokines: Role of Selective Iron Regulatory Protein-2 Downregulation

1998 • 137 citations

Nitric Oxide-inducible Expression of Heme Oxygenase-1 in Human Cells

2000 • 134 citations

Inhibition of AP-1 DNA Binding by Nitric Oxide Involving Conserved Cysteine Residues in Jun and Fos

1998 • 119 citations

Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide

2000 • 118 citations

Stimulation of Immediate Early Gene Expression in Striatal Neurons by Nitric Oxide

1995 • 103 citations

Co-stimulatory effect of nitric oxide on endothelial NF-κB implies a physiological self-amplifying mechanism

1998 • 102 citations

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells

1995 • 99 citations

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2

1999 • 93 citations

Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.

1999 • 92 citations

Activation of Tumor Necrosis Factor-α-converting Enzyme-mediated Ectodomain Shedding by Nitric Oxide

2000 • 90 citations

Regulation of Iron Metabolism in Murine J774 Macrophages: Role of Nitric Oxide–Dependent and –Independent Pathways Following Activation With Gamma Interferon and Lipopolysaccharide

1999 • 90 citations

A Sp1 Binding Site of the Tumor Necrosis Factor α Promoter Functions as a Nitric Oxide Response Element

1999 • 86 citations

Nitric Oxide Regulation of Gene Transcription via Soluble Guanylate Cyclase and Type I cGMP-dependent Protein Kinase

1999 • 77 citations

Endotoxin-Mediated S-Nitrosylation of p50 Alters NF-κB-Dependent Gene Transcription in ANA-1 Murine Macrophages

1999 • 76 citations

Zinc Finger Transcription Factors as Molecular Targets for Nitric Oxide-mediated Immunosuppression: Inhibition of IL-2 Gene Expression in Murine Lymphocytes

1999 • 75 citations

The Function of Nitric Oxide in the Immune System

2000 • 74 citations

Nitric Oxide Inhibits c-Jun N-Terminal Kinase 2 (JNK2) via S-Nitrosylation

1998 • 72 citations

The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism

2000 • 57 citations

Nitric oxide inhibits growth of glomerular mesangial cells: Role of the transcription factor EGR-1

2000 • 56 citations

Rapid Attenuation of AP-1 Transcriptional Factors Associated with Nitric Oxide (NO)-mediated Neuronal Cell Death

1996 • 56 citations

Nitric Oxide Modulates the c-Jun N-terminal Kinase/Stress-Activated Protein Kinase Activity through Activating c-Jun N-Terminal Kinase Kinase

1997 • 53 citations

Nitric oxide and superoxide inhibit platelet-derived growth factor receptor phosphotyrosine phosphatases

1999 • 52 citations

Down-regulation of iron regulatory protein 1 gene expression by nitric oxide

2000 • 52 citations

Biochemistry of Nitric Oxide

2002 • 15 citations

The Discovery of the Biological Synthesis of Nitric Oxide

2002 • 5 citations