The Mitochondrial Thioredoxin System

The mitochondrial permeability transition

1995 • 2,412 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

[21] Thioredoxin and thioredoxin reductase

1995 • 932 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

SELENOCYSTEINE

1996 • 788 citations

The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

1998 • 719 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

RIBONUCLEOTIDE REDUCTASES

1998 • 657 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Detection of catalase in rat heart mitochondria.

1991 • 556 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Nitric oxide, mitochondria and neurological disease

1999 • 474 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae.

1996 • 431 citations

Mutations that Allow Disulfide Bond Formation in the Cytoplasm of Escherichia coli

1993 • 420 citations

Disulfide bond formation in the Escherichia coli cytoplasm: an invivo role reversal for the thioredoxins

1998 • 415 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Cloning and Expression of a Novel Mammalian Thioredoxin

1997 • 391 citations

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer

1996 • 376 citations

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase.

1994 • 361 citations

Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases

1999 • 327 citations

Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols

1995 • 315 citations

Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1→q11.2

1992 • 295 citations

Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

1999 • 277 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide

1994 • 252 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

Distinct Physiological Functions of Thiol Peroxidase Isoenzymes in Saccharomyces cerevisiae

2000 • 241 citations

Identification and Functional Characterization of a Novel Mitochondrial Thioredoxin System in Saccharomyces cerevisiae

1999 • 223 citations

The Role of Iron in Neurodegeneration

1999 • 220 citations

Evidence for mitochondrial dysfunction in Parkinson's disease-a critical appraisal

1994 • 216 citations

The effect of H2O2 upon thioredoxin-enriched lens epithelial cells.

1988 • 214 citations

Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycle

1991 • 209 citations

Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue

1998 • 199 citations

Mitochondria of Saccharomyces cerevisiae Contain One-conserved Cysteine Type Peroxiredoxin with Thioredoxin Peroxidase Activity

2000 • 197 citations

Human mitochondrial thioredoxin reductase

1999 • 178 citations

Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization

1993 • 168 citations

The role of thioredoxin reductase in the reduction of free radicals at the surface of the epidermis

1986 • 165 citations

SP‐22 is a Thioredoxin‐Dependent Peroxide Reductase in Mitochondria

1997 • 159 citations

Cloning, Expression, and Characterization of a NovelEscherichia coli Thioredoxin

1997 • 148 citations

Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability

1998 • 140 citations

Antioxidant Function of the Mitochondrial Protein SP-22 in the Cardiovascular System

1999 • 132 citations

Thioredoxin is required for filamentous phage assembly.

1985 • 131 citations

Cellular and regional distribution of reduced glutathione in the nervous system of the rat: Histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence

1991 • 122 citations

Inhibition of AP-1 DNA Binding by Nitric Oxide Involving Conserved Cysteine Residues in Jun and Fos

1998 • 119 citations

Cloning, sequencing and functional expression of a novel human thioredoxin reductase

1999 • 113 citations

Yeast thioredoxin genes

1991 • 102 citations

Isolation and Characterization of Prototrophic Mutants of Escherichia coli Unable to Support the Intracellular Growth of T7

1974 • 101 citations

Human thioredoxin reductase from HeLa cells: Selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin

1998 • 100 citations

Sulfate-reducing pathway in Escherichia coli involving bound intermediates

1976 • 95 citations

Role of Oxidative Stress and the Glutathione System in Loss of Dopamine Neurons Due to Impairment of Energy Metabolism

1998 • 81 citations

Mitochondrial thioredoxin reductase in bovine adrenal cortex

1999 • 78 citations

Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae.

1996 • 76 citations

Oxidative stress and mitochondrial dysfunction in neurodegeneration.

1994 • 74 citations

Reduction of methionine sulfoxide to methionine by Escherichia coli

1979 • 73 citations

Expression of novel antioxidant thioredoxin‐2 in the rat brain

2000 • 68 citations

Thioredoxin is the bacterial protein encoded by fip that is required for filamentous bacteriophage f1 assembly

1985 • 63 citations

A Redox-Dependent Function of Thioredoxin Is Necessary to Sustain a Rapid Rate of DNA Synthesis in Yeast

1995 • 48 citations

cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene

1999 • 43 citations

Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis.

1994 • 42 citations

Congenital heart defects and 22q11 deletions: which genes count?

1998 • 36 citations

Chemical modification of thiol groups of mitochondrial F1-ATPase from the yeast Schizosaccharomyces pombe. Involvement of alpha- and gamma-subunits in the enzyme activity.

1986 • 32 citations

Thiols in oxidative phosphorylation: Thiols in the F0 of ATP synthase essential for ATPase activity

1987 • 29 citations

Nature of the low activity of S-methyl-coenzyme M reductase as determined by active site titrations.

1993 • 12 citations

Thioredoxin and control of FoF1: function and distribution

1995 • 3 citations