Thymic Selection and Lineage Commitment of CD4+Foxp3+ Regulatory T Lymphocytes

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulation and Function of NF-κB Transcription Factors in the Immune System

2009 • 2,403 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

The Biology of NKT Cells

2006 • 2,052 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Regulatory T cells mediate maternal tolerance to the fetus

2004 • 1,568 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

1945 • 1,352 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

2007 • 1,147 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

2009 • 1,079 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Aire

2009 • 533 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

Regulation of CD8 ⁺ T Cell Development by Thymus-Specific Proteasomes

2007 • 528 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

2007 • 502 citations

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

2008 • 500 citations

Regulatory Lymphocytes and Intestinal Inflammation

2009 • 489 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

Regulatory T Cells in the Control of Host-Microorganism Interactions

2009 • 469 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1998 • 447 citations

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

2008 • 440 citations

Mechanisms maintaining peripheral tolerance

2009 • 433 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Developmental regulation of Foxp3 expression during ontogeny

2005 • 418 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus

2006 • 392 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance

2006 • 294 citations

Checkpoints in lymphocyte development and autoimmune disease

2009 • 293 citations

Dendritic cells in the thymus contribute to T-regulatory cell induction

2008 • 292 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

2009 • 257 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

2008 • 250 citations

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

2009 • 248 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

2009 • 228 citations

Differentiation of regulatory Foxp3⁺T cells in the thymic cortex

2008 • 227 citations

Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells

2007 • 215 citations

Mature T Cells Depend on Signaling through the IKK Complex

2003 • 210 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

2009 • 194 citations

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

2010 • 186 citations

Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

2001 • 183 citations

Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells

2007 • 181 citations

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

2007 • 178 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes

2004 • 167 citations

Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells

2004 • 159 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells

2002 • 150 citations

Identification of Pre- and Postselection TCRαβ+ Intraepithelial Lymphocyte Precursors in the Thymus

2006 • 149 citations

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.

1995 • 145 citations

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

1996 • 144 citations

The impact of negative selection on thymocyte migration in the medulla

2009 • 141 citations

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

2009 • 137 citations

Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype

2009 • 129 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

2005 • 119 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Generalized multi‐organ autoimmunity in CCR7‐deficient mice

2007 • 117 citations

Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.

1987 • 117 citations

A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens

1996 • 116 citations

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

2008 • 115 citations

Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells

1996 • 111 citations

Thymocyte-Thymocyte Interaction for Efficient Positive Selection and Maturation of CD4 T Cells

2005 • 110 citations

Establishment of tissue‐specific tolerance is driven by regulatory T cells selected by thymic epithelium

1996 • 110 citations

A Costimulatory Function for T Cell CD40

2007 • 107 citations

CD40/CD40L interaction regulates CD4⁺CD25⁺ T reg homeostasis through dendritic cell‐produced IL‐2

2005 • 107 citations

Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells

2002 • 106 citations

IL‐2Rβ links IL‐2R signaling with Foxp3 expression

2007 • 101 citations

Early events in the thymus affect the balance of effector and regulatory T cells

2006 • 98 citations

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

2009 • 98 citations

Foxp3 ⁺ CD25 ⁺ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

2006 • 94 citations

CD18 Is Required for Optimal Development and Function of CD4+CD25+ T Regulatory Cells

2005 • 91 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

The role of regulatory T cells in alloantigen tolerance

2006 • 87 citations

Generation of PLZF+ CD4+ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans

2009 • 80 citations

Enhanced thymic selection of FoxP3 ⁺ regulatory T cells in the NOD mouse model of autoimmune diabetes

2007 • 78 citations

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

2009 • 77 citations

Molecular orchestration of differentiation and function of regulatory T cells

2009 • 77 citations

Thymic differentiation of TCRαβ⁺ CD8αα⁺ IELs

2007 • 73 citations

Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics

2007 • 70 citations

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

1993 • 66 citations

Self-Reactive T Cells Selected on Thymic Cortical Epithelium Are Polyclonal and Are Pathogenic In Vivo

1999 • 65 citations

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells

2001 • 60 citations

Differential gene expression in CD3e- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation

1999 • 59 citations

Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients

2006 • 58 citations

Peripheral T Cell Lymphopenia and Concomitant Enrichment in Naturally Arising Regulatory T Cells: The Case of the Pre-Tα Gene-Deleted Mouse

2006 • 54 citations

The extrathymic T‐cell differentiation in the murine gut

2007 • 54 citations

Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells

2009 • 53 citations

Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus

1999 • 51 citations

Increased numbers of thymic and peripheral CD4⁺ CD25⁺Foxp3⁺ cells in the absence of CD5 signaling

2009 • 48 citations

Murine CD8+ regulatory T lymphocytes: The new era

2008 • 48 citations

Thymic selection pathway regulates the effector function of CD4 T cells

2007 • 48 citations

Agonist Ligands Expressed by Thymic Epithelium Enhance Positive Selection of Regulatory T Lymphocytes from Precursors with a Normally Diverse TCR Repertoire

2006 • 47 citations

Distinct functional capacities of mouse thymic and splenic dendritic cell populations

2008 • 45 citations

Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7

2006 • 42 citations

Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection

2007 • 42 citations

Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-A^b complex by isolated thymic stromal cells

1994 • 41 citations

CD4⁺ T‐cell development in a mouse expressing a transgenic TCR derived from a Treg

2008 • 41 citations

Deficiency of the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP-1) Causes Enrichment of CD4+CD25+ Regulatory T Cells

2005 • 39 citations

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message

2009 • 26 citations

Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes

2005 • 26 citations

Genetic control of thymic development of CD4⁺CD25⁺FoxP3⁺ regulatory T lymphocytes

2005 • 22 citations

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes

2006 • 15 citations

Regulatory T Cells and Clinical Application

2008 • 14 citations

Thymic and Peripheral Generation of CD4 + Foxp3 + Regulatory T Cells

2008 • 8 citations