Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Inflammatory Bowel Disease

1991 • 1,264 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

1990 • 1,001 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes

1989 • 552 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

The interleukin-2 receptor.

1991 • 354 citations

Expression of class II molecules on intestinal epithelial cells in humans

1991 • 279 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Immunotherapy of cancer using interleukin 2: current status and future prospects

1988 • 256 citations

Pleiotropy and redundancy: T cell-derived lymphokines in the immune response

1989 • 228 citations

MHC class II expression by the gut epithelium

1988 • 164 citations

Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation

1988 • 163 citations

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.

1988 • 160 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Alterations of IgM, IgG, and IgA Synthesis and Secretion by Peripheral Blood and Intestinal Mononuclear Cells from Patients with Ulcerative Colitis and Crohn's Disease

1981 • 157 citations

Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.

1986 • 143 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Isolation and characteristics of gut mucosal lymphocytes.

1974 • 93 citations

Interleukin-2

1992 • 91 citations

Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.

1990 • 90 citations

The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy.

1991 • 85 citations

Expression of class II molecules on intestinal epithelial cells in humans

1991 • 80 citations

Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel disease

1991 • 79 citations

Loss of interleukin-2—Producing intestinal CD4+ T cells in inflammatory bowel disease

1991 • 72 citations

Role of Intestinal Microflora in Initiation and Perpetuation of Inflammatory Bowel Disease

1990 • 51 citations

In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis.

1990 • 50 citations

The immunology of inflammatory bowel disease

1990 • 37 citations

T lymphocyte subpopulations and immunoglobulin-containing cells in the colonic mucosa of ulcerative colitis; a morphometric and immunohistochemical study.

1988 • 36 citations

Human colonic intra-epithelial lymphocytes are suppressor cells

1991 • 20 citations