The Cellular Mechanism of Aire Control of T Cell Tolerance

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

The enemy within: keeping self-reactive T cells at bay in the periphery

2002 • 586 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

The thymic microenvironment

1993 • 459 citations

The Regulatory T Cell Family: Distinct Subsets and their Interrelations

2003 • 441 citations

Cross-presentation by intercellular peptide transfer through gap junctions

2005 • 430 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

Sex differences in sex chromosome gene expression in mouse brain

2002 • 262 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Back to Central Tolerance

2004 • 202 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

CCR7 Directs the Migration of Thymocytes into the Thymic Medulla

2004 • 173 citations

Directed Migration of Positively Selected Thymocytes Visualized in Real Time

2005 • 169 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

HLA-DM, HLA-DO and tapasin: functional similarities and differences

2002 • 76 citations

Negative selection and autoimmunity

2003 • 70 citations

The TNF Receptor Family Member CD30 Is Not Essential for Negative Selection

2000 • 50 citations

Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

2004 • 40 citations

Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion

1994 • 33 citations