Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling

2000 • 436 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Modulation of NF-κB Activity by Exchange of Dimers

2003 • 297 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Different Cytokines Induce Surface Lymphotoxin-αβ on IL-7 Receptor-α Cells that Differentially Engender Lymph Nodes and Peyer's Patches

2002 • 240 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Transcription of the RelB gene is regulated by NF-κB

2001 • 200 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

Thymic generation and regeneration

2003 • 144 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

TNF Receptor-Associated Factor 6 Deficiency during Hemopoiesis Induces Th2-Polarized Inflammatory Disease

2003 • 57 citations

A novel cofactor produced by a thymic epithelial cell line: Promotion of proliferation of immature thymic lymphocytes by the presence of interleukin-1 and various mitogens

1991 • 20 citations