miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

MicroRNAs

2004 • 33,206 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Real-time quantification of microRNAs by stem-loop RT-PCR

2005 • 4,707 citations

Combinatorial microRNA target predictions

2005 • 4,543 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

MicroRNA Pathways in Flies and Worms

2003 • 1,203 citations

A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis

2005 • 979 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Direct observation of ligand recognition by T cells

2002 • 802 citations

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

2005 • 707 citations

T cell killing does not require the formation of a stable mature immunological synapse

2004 • 569 citations

Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events

2003 • 553 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

2005 • 460 citations

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2003 • 448 citations

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

2006 • 434 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

2004 • 376 citations

Quantitative Analysis of the Contribution of TCR/pepMHC Affinity and CD8 to T Cell Activation

2003 • 355 citations

Protein tyrosine phosphatases and the immune response

2005 • 348 citations

Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

2004 • 325 citations

MAP kinase phosphatases.

2002 • 311 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Two-step binding mechanism for T-cell receptor recognition of peptide–MHC

2002 • 279 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

2004 • 241 citations

Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22

2006 • 233 citations

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands.

1996 • 208 citations

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

1998 • 208 citations

Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

2005 • 181 citations

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

2005 • 150 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Cross-Antagonism of a T Cell Clone Expressing Two Distinct T Cell Receptors

1999 • 108 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation

2004 • 43 citations

The src Homology 2 Domain-Containing Tyrosine Phosphatase 2 Regulates Primary T-Dependent Immune Responses and Th Cell Differentiation

2005 • 42 citations