Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Homing and cellular traffic in lymph nodes

2003 • 1,233 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

2002 • 877 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL

2001 • 318 citations

Characterization of the ovalbumin‐specific TCR transgenic line OT‐I: MHC elements for positive and negative selection

2000 • 279 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Receptor editing in developing T cells

2000 • 157 citations

Autoimmune regulator: from loss of function to autoimmunity

2003 • 137 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

A stochastic view of lymphocyte motility and trafficking within the lymph node

2003 • 115 citations

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

1990 • 112 citations

Cutting Edge: Long-Lived CD8 Memory and Protective Immunity in the Absence of CD40 Expression on CD8 T Cells

2004 • 99 citations

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

2001 • 98 citations

An Immunologically Privileged Retinal Antigen Elicits Tolerance

2003 • 79 citations

Tolerogenicity of thymic epithelium

1990 • 74 citations

V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition.

1994 • 63 citations

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells

2001 • 60 citations

T Cell Tolerance to a Neo-Self Antigen Expressed by Thymic Epithelial Cells: The Soluble Form Is More Effective Than the Membrane-Bound Form

2003 • 52 citations

Cutting Edge: Identification of the Targets of Clonal Deletion in an Unmanipulated Thymus

2003 • 29 citations

Visualizing thymocyte motility using 2‐photon microscopy

2003 • 21 citations