An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

2004 • 955 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

The Bare Lymphocyte Syndrome and the Regulation of MHC Expression

2001 • 516 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells

1999 • 456 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

2004 • 366 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

T-cell development made simple

2004 • 299 citations

Mini‐review: Specificity and expression of CIITA, the master regulator of MHC class II genes

2004 • 271 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

Reentry of T cells to the adult thymus is restricted to activated T cells.

1991 • 263 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model

2003 • 252 citations

NK1.1+ T Cells in the Liver Arise in the Thymus and Are Selected by Interactions with Class I Molecules on CD4+CD8+ Cells

2000 • 217 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Functional Human T Lymphocyte Development from Cord Blood CD34+ Cells in Nonobese Diabetic/Shi-scid, IL-2 Receptor γ Null Mice

2002 • 174 citations

Thymic dendritic cells

1997 • 163 citations

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes.

1994 • 155 citations

Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

2002 • 151 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras.

1981 • 135 citations

Intercellular transfer of antigen‐presenting cell determinants onto T cells: molecular mechanisms and biological significance

2002 • 103 citations

Bone marrow transplantation in major histocompatibility complex class II deficiency: a single-center study of 19 patients

1995 • 99 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

Controlling the thymic microenvironment

2005 • 92 citations

CIITA activates the expression of MHC class II genes in mouse T cells

1995 • 75 citations

Fibroblasts can induce thymocyte positive selection in vivo.

1993 • 73 citations

A kinetic study of the murine mixed lymphocyte reaction by 5,6-carboxyfluorescein diacetate succinimidyl ester labeling

2003 • 52 citations

TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type

2000 • 48 citations

T-cell generation by lymph node resident progenitor cells

2005 • 46 citations

Phenotypic characterization of murine thymic microenvironments.

1990 • 43 citations

Tracing interactions of thymocytes with individual stromal cell partners

1996 • 40 citations

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

2003 • 36 citations

Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures.

1996 • 36 citations

HLA-DR expression in human fetal thymocytes

1992 • 34 citations

Thymocytes Positively Select Thymocytes in Human System

1997 • 27 citations

Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus

2005 • 24 citations

The in vivo development of human T cells from CD34+ cells in the murine thymic environment

2002 • 23 citations

Presence of HLA-DR Immunopositive Cells in Human Fetal Thymus

2001 • 17 citations

T cell immune reconstitution after allogeneic bone marrow transplantation in bare lymphocyte syndrome

2000 • 15 citations

Altered Th1 Cell Differentiation Programming by CIITA Deficiency

2004 • 13 citations

Superantigens Are Presented by and Activate Thymocytes from Infants

1999 • 11 citations

HLA-DR antigens and Fc gamma receptors in fetal and infant thymus, examined by a double-marker technique.

1983 • 3 citations