Checkpoints in lymphocyte development and autoimmune disease

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

The Biology of NKT Cells

2006 • 2,052 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

1999 • 1,464 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

2009 • 1,079 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

2003 • 822 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Defective B cell tolerance checkpoints in systemic lupus erythematosus

2005 • 677 citations

Genes and Antibodies

1959 • 675 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation

2007 • 601 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus

2006 • 392 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Receptor editing in lymphocyte development and central tolerance

2006 • 341 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing

1995 • 313 citations

Sites and Stages of Autoreactive B Cell Activation and Regulation

2008 • 304 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

Residues that mediate DNA binding of autoimmune antibodies.

1993 • 268 citations

TCR Signal Strength Influences αβ/γδ Lineage Fate

2005 • 262 citations

Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation

2004 • 254 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

1997 • 253 citations

B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen

2002 • 252 citations

Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor

2005 • 249 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

2009 • 248 citations

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity

2009 • 247 citations

The Clonal-Selection Theory

1987 • 244 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Regulation of B Cell Tolerance by the Lupus Susceptibility Gene Ly108

2006 • 242 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 237 citations

Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

2005 • 227 citations

Differentiation of regulatory Foxp3⁺T cells in the thymic cortex

2008 • 227 citations

The thymus and negative selection

2002 • 216 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 203 citations

BAFF is a survival and maturation factor for mouse B cells

2002 • 201 citations

A decade of AIRE

2007 • 188 citations

Thymic selection revisited: how essential is it?

2003 • 186 citations

The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

2005 • 184 citations

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

2008 • 183 citations

Editors and Editing of Anti-DNA Receptors

2001 • 182 citations

B‐Cell Self‐Tolerance in Humans

2007 • 181 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

The timing of TCRα expression critically influences T cell development and selection

2005 • 179 citations

A protective role for innate immunity in systemic lupus erythematosus

2004 • 171 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells

2004 • 159 citations

The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling

2003 • 157 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

2005 • 150 citations

Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.

2011 • 149 citations

Type 1 diabetes genes and pathways shared by humans and NOD mice

2005 • 146 citations

Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies

2003 • 144 citations

Multiple organ-reactive monoclonal autoantibodies

1983 • 142 citations

Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development

2004 • 134 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

Expression of two T cell receptor α chains on the surface of normal murine T cells

1995 • 131 citations

Allelic Inclusion of T Cell Receptor α Genes Poses an Autoimmune Hazard Due to Low-Level Expression of Autospecific Receptors

1998 • 129 citations

Censoring of Autoreactive B Cell Development by the Pre-B Cell Receptor

2008 • 128 citations

Human autoantibody recognition of DNA.

1995 • 122 citations

T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis

2008 • 111 citations

Interaction of Murine Precursor B Cell Receptor with Stroma Cells Is Controlled by the Unique Tail of λ5 and Stroma Cell-Associated Heparan Sulfate

2003 • 111 citations

Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

1992 • 109 citations

Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells

2008 • 107 citations

Contribution of VH Gene Replacement to the Primary B Cell Repertoire

2003 • 105 citations

B cell development in mice with a defective λ₅ gene

1993 • 104 citations

Frequencies of Multiple IgL Chain Gene Rearrangements in Single Normal or κL Chain–Deficient B Lineage Cells

1999 • 79 citations

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

2002 • 76 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors

2007 • 68 citations

Lupus Susceptibility Genes May Breach Tolerance to DNA by Impairing Receptor Editing of Nuclear Antigen-Reactive B Cells

2007 • 66 citations

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse

2004 • 59 citations

Assembly of Productive T Cell Receptor δ Variable Region Genes Exhibits Allelic Inclusion

1998 • 59 citations

Antibody Repertoires Generated by VH Replacement and Direct VH to JH Joining

2006 • 59 citations

Marked differences in the efficiency of expression of distinct alphabeta T cell receptor heterodimers

1990 • 57 citations

Mutations Affecting Either Generation or Survival of Cells Influence the Pool Size of Mature B Cells

1999 • 57 citations

Unraveling B-1 progenitors

2007 • 53 citations

Rearrangement and expression of χ light chain genes can occur without μ heavy chain expression during differentiation of pre-B cells

1993 • 51 citations

Marked differences in the efficiency of expression of distinct alpha beta T cell receptor heterodimers.

1989 • 49 citations

Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro

1998 • 46 citations

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

2007 • 44 citations

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

2008 • 42 citations

Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction

2006 • 41 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling.

2007 • 40 citations

PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr

2007 • 36 citations

Consequences of receptor editing at the λ locus: Multireactivity and light chain secretion

2006 • 35 citations

Induction of sterile transcription from the kL chain gene locus in V(D)J recombinasedeficient progenitor B cells

1995 • 35 citations

B Cell Tolerance—How to Make It and How to Break It

2006 • 33 citations

Clonal Selection Theory

1960 • 31 citations

Editing and escape from editing in anti-DNA B cells

2008 • 30 citations

VH Replacement Rescues Progenitor B Cells with Two Nonproductive VDJ Alleles

2006 • 30 citations

The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

2005 • 27 citations

Does Immunological Tolerance Explain the Waste in the B‐Lymphocyte Immune System? Experiment and Theory^a

1995 • 25 citations

Do NKT cells control autoimmunity?

2002 • 17 citations

Two Distinct Populations of H Chain-Edited B Cells Show Differential Surrogate L Chain Dependence

2009 • 14 citations

Positive and negative selection in Basel

2008 • 8 citations

Deleted Work

1955 • 0 citations