Intraclonal competition limits the fate determination of regulatory T cells in the thymus

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

2007 • 438 citations

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

2008 • 406 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

1995 • 273 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells

2007 • 215 citations

Antigen-specific peripheral shaping of the natural regulatory T cell population

2008 • 185 citations

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

2007 • 178 citations

Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition

2003 • 123 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease.

1990 • 120 citations

Early events in the thymus affect the balance of effector and regulatory T cells

2006 • 98 citations

Foxp3 ⁺ CD25 ⁺ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

2006 • 94 citations

Unique role of CD4⁺CD62L⁺regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice

2004 • 92 citations

Competition for antigen determines the stability of T cell–dendritic cell interactions during clonal expansion

2007 • 87 citations

Enhanced thymic selection of FoxP3 ⁺ regulatory T cells in the NOD mouse model of autoimmune diabetes

2007 • 78 citations

Gene therapy of apolipoprotein E–deficient mice using a novel macrophage-specific retroviral vector

2002 • 61 citations

Competition for Specific Intrathymic Ligands Limits Positive Selection in a TCR Transgenic Model of CD4+ T Cell Development

2000 • 39 citations

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

2003 • 36 citations

Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes

2005 • 26 citations