Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

2006 • 1,647 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.

2017 • 986 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

The lifestyle of naturally occurring CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2006 • 589 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Developmental regulation of Foxp3 expression during ontogeny

2005 • 418 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

Regulatory T cells and intestinal homeostasis

2005 • 279 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Lymph Node Occupancy Is Required for the Peripheral Development of Alloantigen-Specific Foxp3+ Regulatory T Cells

2005 • 182 citations

The role of the transcription factor Foxp3 in the development of regulatory T cells

2006 • 181 citations

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells

2007 • 178 citations

The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

2003 • 154 citations

Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes

2007 • 144 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells

2002 • 106 citations

Early events in the thymus affect the balance of effector and regulatory T cells

2006 • 98 citations

Foxp3 ⁺ CD25 ⁺ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

2006 • 94 citations

TCR-Independent Pathways Mediate the Effects of Antigen Dose and Altered Peptide Ligands on Th Cell Polarization

1999 • 83 citations

Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection

2005 • 83 citations

CD4+ CD25+ Regulatory T Cell Repertoire Formation in Response to Varying Expression of a neo-Self-Antigen

2004 • 76 citations

A unified theory of central tolerance in the thymus

2006 • 63 citations

Most human thymic and peripheral-blood CD4+CD25+ regulatory T cells express 2 T-cell receptors

2006 • 45 citations

CD4⁺ CD25⁺ Regulatory T Cell Selection

2004 • 40 citations

Activation of CD4⁺CD25⁺ regulatory T cell suppressor function by analogs of the selecting peptide

2006 • 25 citations

Regulatory T Cells in Experimental Colitis

2005 • 22 citations

Differential Recognition of Altered Peptide Ligands Distinguishes Two Functionally Discordant (Arthritogenic and Nonarthritogenic) Autoreactive T Cell Hybridoma Clones

2003 • 21 citations

The contribution of mutant amino acids to alloantigenicity.

1989 • 19 citations

The role of autoreactive T-cell hybridomas from autoimmune model mice.

1988 • 4 citations