The Biology of NKT Cells

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Primary Biliary Cirrhosis

1987 • 1,981 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

NKT cells: what's in a name?

2004 • 1,133 citations

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

2005 • 1,111 citations

Primary Biliary Cirrhosis

2005 • 1,064 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

CD1: Antigen Presentation and T Cell Function

2004 • 1,025 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Lysosomal Glycosphingolipid Recognition by NKT Cells

2004 • 946 citations

Recognition of bacterial glycosphingolipids by natural killer T cells

2005 • 918 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

2000 • 891 citations

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

2001 • 864 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Primary Biliary Cirrhosis

2015 • 829 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining

2002 • 758 citations

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

1993 • 714 citations

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

2003 • 706 citations

Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

2003 • 698 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

2004 • 689 citations

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

2003 • 670 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids

2005 • 649 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

2006 • 624 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation

2004 • 587 citations

Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

1995 • 569 citations

Distinct Functional Lineages of Human Vα24 Natural Killer T Cells

2002 • 567 citations

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

2001 • 556 citations

In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers

1999 • 551 citations

Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs

2002 • 529 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

A Thymic Precursor to the NK T Cell Lineage

2002 • 517 citations

Murine CD1d-Restricted T Cell Recognition of Cellular Lipids

2000 • 467 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

Glycolipid antigen induces long-term natural killer T cell anergy in mice

2005 • 437 citations

NKT cells derive from double-positive thymocytes that are positively selected by CD1d

2001 • 421 citations

CD4+ Invariant T-Cell–Receptor+ Natural Killer T Cells in Bronchial Asthma

2006 • 414 citations

A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma

2003 • 412 citations

Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients

2005 • 411 citations

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

1998 • 399 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

Regulation of NKT cell development by SAP, the protein defective in XLP

2005 • 388 citations

CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells

1999 • 386 citations

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 • 384 citations

Differential antitumor immunity mediated by NKT cell subsets in vivo

2005 • 383 citations

The crystal structure of human CD1d with and without α-galactosylceramide

2005 • 379 citations

Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

2004 • 375 citations

A Natural Killer T (NKT) Cell Developmental Pathway Involving a Thymus-dependent NK1.1−CD4+ CD1d-dependent Precursor Stage

2002 • 374 citations

Loss of IFN-γ Production by Invariant NK T Cells in Advanced Cancer

2001 • 370 citations

Apolipoprotein-mediated pathways of lipid antigen presentation

2005 • 363 citations

KRN7000, a novel immunomodulator, and its antitumor activities.

1995 • 361 citations

Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis

1999 • 361 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 • 347 citations

The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

1997 • 339 citations

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

2005 • 338 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

CD1d-dependent Activation of NKT Cells Aggravates Atherosclerosis

2004 • 327 citations

Activation events during thymic selection.

1992 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Modulation of CD1d-restricted NKT cell responses by usingN-acyl variants of α-galactosylceramides

2005 • 320 citations

Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines

2002 • 314 citations

Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model

2003 • 313 citations

How the T Cell Repertoire Becomes Peptide and MHC Specific

2005 • 310 citations

Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins

2003 • 310 citations

Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium

2003 • 310 citations

CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung

2002 • 309 citations

Cell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells

2005 • 305 citations

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor

2005 • 305 citations

Glycolipid Antigen Processing for Presentation by CD1d Molecules

2001 • 289 citations

SAP couples Fyn to SLAM immune receptors

2003 • 282 citations

Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells

2003 • 279 citations

A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance

2005 • 278 citations

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

2003 • 274 citations

Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes

2001 • 273 citations

Characterization of the early stages of thymic NKT cell development

2005 • 272 citations

An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

1992 • 270 citations

Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments

1999 • 269 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

2004 • 263 citations

Genetic Evidence Supporting Selection of the Vα14i NKT Cell Lineage from Double-Positive Thymocyte Precursors

2005 • 262 citations

Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

1997 • 258 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains

2002 • 250 citations

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

2004 • 243 citations

Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells

2005 • 242 citations

Assistance of Microbial Glycolipid Antigen Processing by CD1e

2005 • 237 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 237 citations

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

1995 • 237 citations

Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice

1998 • 233 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells

1998 • 230 citations

Human CD1-restricted T cell recognition of lipids from pollens

2005 • 229 citations

Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation

2004 • 228 citations

Mouse CD1 is mainly expressed on hemopoietic-derived cells.

1997 • 226 citations

SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

2004 • 223 citations

NK1.1+ T Cells in the Liver Arise in the Thymus and Are Selected by Interactions with Class I Molecules on CD4+CD8+ Cells

2000 • 217 citations

Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer

2002 • 212 citations

A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.

1999 • 209 citations

CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain

2001 • 207 citations

Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells

2004 • 202 citations

CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant Vα24JαQ T Cell Receptor α Chains

1998 • 200 citations

Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant Vα14-Jα281 TCR

2003 • 199 citations

The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells

2004 • 198 citations

Effects of Lipid Chain Lengths in α-Galactosylceramides on Cytokine Release by Natural Killer T Cells

2004 • 194 citations

Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail–truncated CD1d

2001 • 192 citations

The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells

2004 • 192 citations

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity

2005 • 191 citations

Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi

2000 • 189 citations

The Src Family Tyrosine Kinase Fyn Regulates Natural Killer T Cell Development

1999 • 186 citations

Altered Development of CD8+ T Cell Lineages in Mice Deficient for the Tec Kinases Itk and Rlk

2006 • 185 citations

The Tec Family Tyrosine Kinases Itk and Rlk Regulate the Development of Conventional CD8+ T Cells

2006 • 184 citations

Human CD1d–glycolipid tetramers generated byin vitrooxidative refolding chromatography

2001 • 183 citations

The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

2004 • 181 citations

Molecular Interaction of CD1b with Lipoglycan Antigens

1998 • 180 citations

Biosynthesis and degradation of mammalian glycosphingolipids

2003 • 179 citations

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

2001 • 176 citations

NKT Cell Stimulation with Glycolipid Antigen In Vivo: Costimulation-Dependent Expansion, Bim-Dependent Contraction, and Hyporesponsiveness to Further Antigenic Challenge

2005 • 175 citations

Failure of Trafficking and Antigen Presentation by CD1 in AP-3-Deficient Cells

2002 • 174 citations

The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families

2001 • 174 citations

The cell envelope structure of the lipopolysaccharide-lacking gram-negative bacterium Sphingomonas paucimobilis

1994 • 173 citations

CD1d function is regulated by microsomal triglyceride transfer protein

2004 • 171 citations

Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions

2005 • 171 citations

Cutting Edge: NKT Cell Development Is Selectively Impaired in Fyn- Deficient Mice

1999 • 167 citations

NKT Cells Inhibit the Onset of Diabetes by Impairing the Development of Pathogenic T Cells Specific for Pancreatic β Cells

2002 • 163 citations

A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

1999 • 163 citations

A modified α-galactosyl ceramide for staining and stimulating natural killer T cells

2006 • 163 citations

Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes

2005 • 163 citations

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy

2004 • 161 citations

Regulation of CD1d expression and function by a herpesvirus infection

2005 • 159 citations

Tissue-Specific Recognition of Mouse CD1 Molecules

1998 • 158 citations

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

2003 • 158 citations

Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo

2005 • 157 citations

CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation

1991 • 155 citations

Vα24-JαQ-Independent, CD1d-Restricted Recognition of α-Galactosylceramide by Human CD4+ and CD8αβ+ T Lymphocytes

2002 • 153 citations

Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells

2005 • 153 citations

Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling

2006 • 153 citations

Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation

2002 • 151 citations

Production of Profibrotic Cytokines by Invariant NKT Cells Characterizes Cirrhosis Progression in Chronic Viral Hepatitis

2004 • 150 citations

Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-<scp>d</scp>-glucosylceramide synthase deficiency

2003 • 148 citations

Rapid screening and dereplication of bacterial isolates from marine sponges of the Sula Ridge by Intact-Cell-MALDI-TOF mass spectrometry (ICM-MS)

2004 • 146 citations

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

2003 • 146 citations

CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells

2003 • 144 citations

Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct α- and β-Anomeric Glycolipids

2004 • 144 citations

T-bet concomitantly controls migration, survival, and effector functions during the development of Vα14i NKT cells

2005 • 143 citations

Cutting Edge: The IgG Response to the Circumsporozoite Protein Is MHC Class II-Dependent and CD1d-Independent: Exploring the Role of GPIs in NK T Cell Activation and Antimalarial Responses

2000 • 138 citations

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases

2006 • 137 citations

Hepatic CD1d Expression in Hepatitis C Virus Infection and Recognition by Resident Proinflammatory CD1d-Reactive T Cells

2004 • 137 citations

Requirement for membrane lymphotoxin in natural killer cell development

1999 • 137 citations

Regulation of CD1d expression and function by a herpesvirus infection

2005 • 136 citations

Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d

2006 • 134 citations

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

2003 • 133 citations

The Vα14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex

2002 • 128 citations

Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules

2002 • 120 citations

NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of Vα14i NKT Cells

2003 • 120 citations

Structural analysis of two glycosphingolipids from the lipopolysaccharide‐lacking bacterium Sphingomonas capsulata

2000 • 120 citations

An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

2005 • 119 citations

The SLAM family of immune-cell receptors

2003 • 119 citations

Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice

2000 • 118 citations

Sequence and expression of transcripts of the T-cell antigen receptor alpha-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma.

1986 • 118 citations

Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells

2002 • 118 citations

The Influence of CD1d in Postselection NKT Cell Maturation and Homeostasis

2005 • 117 citations

Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum

2002 • 117 citations

Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain

2002 • 116 citations

Murine thymic CD4+ T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene family.

1992 • 115 citations

Commitment toward the natural T (iNKT) cell lineage occurs at the CD4⁺8⁺stage of thymic ontogeny

2005 • 115 citations

Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

1990 • 114 citations

Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples

2005 • 113 citations

Thymocyte expression of cathepsin L is essential for NKT cell development

2002 • 110 citations

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

2006 • 107 citations

Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice.

1991 • 101 citations

Synthesis and NKT Cell Stimulating Properties of Fluorophore- and Biotin-Appended 6‘ ‘-Amino-6‘ ‘-deoxy-galactosylceramides

2002 • 100 citations

NF-κB Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes

2004 • 100 citations

Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

2002 • 100 citations

Interplay of Cytokines and Microbial Signals in Regulation of CD1d Expression and NKT Cell Activation

2005 • 100 citations

Mechanisms imposing the Vβ bias of Vα14 natural killer T cells and consequences for microbial glycolipid recognition

2006 • 99 citations

Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis

2003 • 98 citations

Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors

2006 • 98 citations

Lysosomal Localization of Murine CD1d Mediated by AP-3 Is Necessary for NK T Cell Development

2003 • 96 citations

Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci

2003 • 93 citations

Structure and binding kinetics of three different human CD1d–α-galactosylceramide–specific T cell receptors

2006 • 90 citations

The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs

2003 • 88 citations

Activation of Invariant NKT Cells by the Helminth Parasite Schistosoma mansoni

2006 • 88 citations

Role of CD1d in Coxsackievirus B3-Induced Myocarditis

2003 • 86 citations

Inhibition of glycolipid shedding rescues recognition of a CD1⁺T cell lymphoma by natural killer T (NKT) cells

2002 • 86 citations

Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted γδ T cells

2006 • 85 citations

Critical Role of NK Cells Rather Than Vα14+NKT Cells in Lipopolysaccharide-Induced Lethal Shock in Mice

2002 • 84 citations

The natural killer T cell ligand α‐galactosylceramide prevents or promotes pristane‐induced lupus in mice

2005 • 82 citations

Extravascular T-cell recruitment requires initiation begun by Vα14+ NKT cells and B-1 B cells

2004 • 81 citations

CD1d-restricted mouse Vα14 and human Vα24 T cells: lymphocytes of innate immunity

2000 • 79 citations

CD1d-Specific NK1.1+ T Cells with a Transgenic Variant TCR

2000 • 79 citations

Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein

2006 • 78 citations

NK Cells, but Not NKT Cells, Are Involved in Pseudomonas aeruginosa Exotoxin A-Induced Hepatotoxicity in Mice

2004 • 78 citations

Synthesis and biological evaluation of α-galactosylceramide (KRN7000) and isoglobotrihexosylceramide (iGb3)

2006 • 78 citations

Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase Cθ and NF-κB

2004 • 76 citations

Dendritic Cell Maturation Overrules H-2d–Mediated Natural Killer T (Nkt) Cell Inhibition

2001 • 76 citations

Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-FaslprMice: An Example of Disease Regulation at the Organ Level

2001 • 75 citations

Cutting Edge: Influence of the TCR Vβ Domain on the Selection of Semi-Invariant NKT Cells by Endogenous Ligands

2006 • 73 citations

The Bovine CD1 Family Contains Group 1 CD1 Proteins, but No Functional CD1d

2006 • 72 citations

Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black × New Zealand White)F1 Mice

2005 • 69 citations

Signaling for NKT cell development

2005 • 69 citations

Lack of directed Vα14‐Jα281 rearrangements in NK1⁺ T cells

1997 • 67 citations

Membrane Lymphotoxin Is Required for the Development of Different Subpopulations of NK T Cells

2000 • 67 citations

CD1d deficiency exacerbates inflammatory dermatitis in MRL‐lpr/lpr mice

2004 • 65 citations

Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

1997 • 65 citations

Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis

2001 • 64 citations

Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1+ T Cells

1998 • 64 citations

Resistance of Natural Killer T Cell–Deficient Mice to Systemic Shwartzman Reaction

2000 • 63 citations

The editorialist replies [5]

2006 • 63 citations

Targeted Expression of Human CD1d in Transgenic Mice Reveals Independent Roles for Thymocytes and Thymic APCs in Positive and Negative Selection of Vα14i NKT Cells

2005 • 60 citations

Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny

2006 • 59 citations

The Mouse CD1d Cytoplasmic Tail Mediates CD1d Trafficking and Antigen Presentation by Adaptor Protein 3-Dependent and -Independent Mechanisms

2005 • 59 citations

iNKT-Cell Responses to Glycolipids

2005 • 55 citations

Enhancing effects of (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-2-(N-hexacosanoylamino) -1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000-pretreated antigen-presenting cells.

1996 • 54 citations

The Contribution of NKT Cells, NK Cells, and Other γ-Chain-Dependent Non-T Non-B Cells to IL-12-Mediated Rejection of Tumors

2003 • 53 citations

Development of Valpha4+ NK T cells in the early stages of embryogenesis.

1996 • 52 citations

Inhibition of antitumor immunity by invariant natural killer T cells in a T‐cell lymphoma model in vivo

2006 • 50 citations

CD1d‐restricted NK T cells are dispensable for specific antibody responses and protective immunity against liver stage malaria infection in mice

2001 • 50 citations

Role of lipid trimming and CD1 groove size in cellular antigen presentation

2006 • 49 citations

NKT Cells in the Rat: Organ-Specific Distribution of NK T Cells Expressing Distinct Vα14 Chains

2000 • 47 citations

Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing

1998 • 44 citations

Ligand-dependent Inhibition of CD1d-restricted NKT Cell Development in Mice Transgenic for the Activating Receptor Ly49D

2003 • 44 citations

BATF Transgenic Mice Reveal a Role for Activator Protein-1 in NKT Cell Development

2003 • 44 citations

Absolute requirement for the pre-T cell receptor α chain during NK1.1+ TCRα β cell development

1999 • 43 citations

A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function

2006 • 42 citations

NKT cells are not critical for HSV‐1 disease resolution

2005 • 41 citations

The Role of Innate Immunity in Autoimmunity

2004 • 40 citations

Invariant NKT Cells Exacerbate Type 1 Diabetes Induced by CD8 T Cells

2005 • 39 citations

DOCK2 Is Required in T Cell Precursors for Development of Vα14 NK T Cells

2006 • 36 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 36 citations

CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination

2001 • 34 citations

In This Issue

2002 • 34 citations

The Complementarity Determining Region 2 of BV8S2 (Vβ8.2) Contributes to Antigen Recognition by Rat Invariant NKT Cell TCR

2006 • 33 citations

Expression of CD1d Under the Control of a MHC Class Ia Promoter Skews the Development of NKT Cells, But Not CD8+ T Cells

2003 • 32 citations

A unique lymphotoxin αβ-dependent pathway regulates thymic emigration of Vα14 invariant natural killer T cells

2006 • 31 citations

Genetic and Functional Analysis of theNkt1Locus Using Congenic NOD Mice

2006 • 30 citations

Injury-Induced Suppression of Effector T Cell Immunity Requires CD1d-Positive APCs and CD1d-Restricted NKT Cells

2006 • 30 citations

Sensitivity of NK1.1-Negative NKT Cells to Transgenic BATF Defines a Role for Activator Protein-1 in the Expansion and Maturation of Immature NKT Cells in the Thymus

2007 • 29 citations

Restoration of NK T Cell Development infyn-Mutant Mice by a TCR Reveals a Requirement for Fyn During Early NK T Cell Ontogeny

2004 • 27 citations

CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo

2006 • 25 citations

Heterophile anti-mouse immunoglobulin antibodies may interfere with cytokine measurements in patients with HLA alleles protective for type 1A diabetes.

1999 • 21 citations

Activation of acceptor-suppressor hybridoma with antigen-specific suppressor T cell factor of two-chain type: requirement of the antigen- and the I-J-restricting specificity.

1984 • 18 citations

Testing the NKT cell hypothesis of human IDDM pathogenesis

2002 • 12 citations

Novel mechanisms of specific suppression of anti-hapten antibody response mediated by monoclonal anti-carrier antibody.

1985 • 10 citations

Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice

2000 • 6 citations