Murine CD8+ regulatory T lymphocytes: The new era

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Infectious immunological tolerance.

1971 • 811 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

The lifestyle of naturally occurring CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2006 • 589 citations

Oral tolerance

2005 • 573 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

2007 • 502 citations

A molecular map of the immune response region from the major histocompatibility complex of the mouse

1982 • 466 citations

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

2006 • 463 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

2003 • 388 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.

1976 • 363 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

2004 • 330 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis

2004 • 305 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.

1976 • 279 citations

Cutting Edge: CD8+CD122+ Regulatory T Cells Produce IL-10 to Suppress IFN-γ Production and Proliferation of CD8+ T Cells

2005 • 268 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut Integrity

2002 • 227 citations

ANTERIOR CHAMBER ASSOCIATED IMMUNE DEVIATION (ACAID): REGULATION, BIOLOGICAL RELEVANCE, AND IMPLICATIONS FOR THERAPY

2002 • 210 citations

Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation

2004 • 198 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells

1989 • 197 citations

Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients with Inflammatory Bowel Disease

2005 • 182 citations

CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-γ, and indoleamine 2,3-dioxygenase

2007 • 178 citations

Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes

2004 • 167 citations

Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells

2002 • 165 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein

1990 • 164 citations

Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells

2004 • 159 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex.

1983 • 145 citations

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

2008 • 144 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

Tolerogenic Treatment of Lupus Mice with Consensus Peptide Induces Foxp3-Expressing, Apoptosis-Resistant, TGFβ-Secreting CD8+ T Cell Suppressors

2005 • 134 citations

Exacerbated graft-versus-host disease in Pirb−/− mice

2004 • 126 citations

CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site

2003 • 124 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells.

1985 • 118 citations

Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus

2001 • 110 citations

CD8+CD28− Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice

2006 • 109 citations

Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection

2004 • 104 citations

Essential role of CD8[+]CD122[+] regulatory T cells in the recovery from experimental autoimmune encephalomyelitis

2008 • 103 citations

Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells.

1996 • 101 citations

Peptide-Specific CD8 T Regulatory Cells Use IFN-γ to Elaborate TGF-β-Based Suppression

2005 • 100 citations

CD8+ T Cell-Mediated Suppression of Autoimmunity in a Murine Lupus Model of Peptide-Induced Immune Tolerance Depends on Foxp3 Expression

2007 • 100 citations

Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity

2005 • 98 citations

Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte–associated Antigen 4

2003 • 98 citations

CRITICAL ROLE OF INTERLEUKIN 4 IN THE INDUCTION OF NEONATAL TRANSPLANTATION TOLERANCE

1995 • 96 citations

Regulation of Immunity by a Novel Population of Qa-1-Restricted CD8αα+TCRαβ+ T Cells

2006 • 92 citations

Induction of TCR Vβ-Specific CD8+ CTLs by TCR Vβ-Derived Peptides Bound to HLA-E

2001 • 78 citations

Oral Exposure to Alloantigen Generates Intragraft CD8+ Regulatory Cells

2001 • 74 citations

Ocular Immune Privilege Promoted by the Presentation of Peptide on Tolerogenic B Cells in the Spleen. II. Evidence for Presentation by Qa-1

2001 • 71 citations

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering

2003 • 71 citations

Structural and Functional Characteristics of the Class Ib Molecule, Qa-1

1995 • 70 citations

pConsensus Peptide Induces Tolerogenic CD8+ T Cells in Lupus-Prone (NZB × NZW)F1 Mice by Differentially Regulating Foxp3 and PD1 Molecules

2008 • 64 citations

Special regulatory T‐cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

2007 • 64 citations

B7+ Iris Pigment Epithelium Induce CD8+ T Regulatory Cells; Both Suppress CTLA-4+ T Cells

2006 • 56 citations

TCR transgenic CD8+ T cells activated in the presence of TGF express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection

2006 • 55 citations

The extrathymic T‐cell differentiation in the murine gut

2007 • 54 citations

Functional and Genetic Analysis of Two CD8 T Cell Subsets Defined by the Level of CD45RC Expression in the Rat

2004 • 43 citations

CTLA-4+CD8+ T Cells That Encounter B7-2+ Iris Pigment Epithelial Cells Express Their Own B7-2 to Achieve Global Suppression of T Cell Activation

2004 • 42 citations

Regulatory CD8+ T Cells Control Neonatal Tolerance to a Th2-Mediated Autoimmunity

2003 • 42 citations

CD8+ T-cell–mediated killing of donor dendritic cells prevents alloreactive T helper type-2 responses in vivo

2006 • 38 citations

The suppression of delayed‐type hypersensitivity by CD8⁺ regulatory T cells requires interferon‐γ

2006 • 36 citations

Transforming growth factor β-producing Foxp3+CD8+CD25+ T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions

2007 • 35 citations

CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation

2006 • 27 citations

THE TRANSFER OF IMMUNOLOGICAL COMPETENCE TO RATS TOLERANT OF SHEEP ERYTHROCYTES WITH LYMPHOCYTES FROM NORMAL RATS

1970 • 27 citations

Implication for the CD94/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells

2008 • 25 citations

Special regulatory T‐cell review: T‐cell dependent suppression revisited

2007 • 20 citations

CD75s is a marker of murine CD8+ suppressor T cells

2003 • 18 citations

Increased expression of Foxp3 in splenic CD8+ T cells from mice with anterior chamber-associated immune deviation.

2007 • 15 citations

Special regulatory T‐cell review: suppressors regulated but unsuppressed¹

2007 • 14 citations

Characterization of the epitope recognized by a mAb that reacts differentially with murine suppressor T cells

1995 • 7 citations

Special regulatory T cell review: The suppression problem!

2007 • 6 citations